Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory [0.03%]
人脑海马CA3区使用特定功能连接规则以实现高效联想记忆
Jake F Watson,Victor Vargas-Barroso,Rebecca J Morse-Mora et al.
Jake F Watson et al.
Our brain has remarkable computational power, generating sophisticated behaviors, storing memories over an individual's lifetime, and producing higher cognitive functions. However, little of our neuroscience knowledge covers the human brain...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms [0.03%]
可移动元件的外显子化产生了进化中的功能性蛋白质异构体的一系列新产物
Yago A Arribas,Blandine Baudon,Maxime Rotival et al.
Yago A Arribas et al.
Alternative splicing enhances protein diversity in different ways, including through exonization of transposable elements (TEs). Recent transcriptomic analyses identified thousands of unannotated spliced transcripts with exonizing TEs, but ...
Bibekananda Sahoo,Zongjun Mou,Wei Liu et al.
Bibekananda Sahoo et al.
Ninjurin-1 (NINJ1) is an active executioner of plasma membrane rupture (PMR), a process previously thought to be a passive osmotic lysis event in lytic cell death. Ninjurin-2 (NINJ2) is a close paralog of NINJ1 but cannot mediate PMR. Using...
Benedikt Goretzki,Maryam Khoshouei,Martin Schröder et al.
Benedikt Goretzki et al.
Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin l...
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor [0.03%]
一种常见的人PCSK9基因变异通过LRP1受体促进乳腺癌转移
Wenbin Mei,Schayan Faraj Tabrizi,Christopher Godina et al.
Wenbin Mei et al.
Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convertase subtilisin/kexin type 9 (PCSK9) (rs562556, V474I) that is associated with reduced surv...
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing [0.03%]
利用逆行追踪法表征并靶向胶质母细胞瘤神经-肿瘤网络
Svenja K Tetzlaff,Ekin Reyhan,Nikolas Layer et al.
Svenja K Tetzlaff et al.
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has been hampered by a lack of t...
Jazmín Ramos-Madrigal,Gayle J Fritz,Bryon Schroeder et al.
Jazmín Ramos-Madrigal et al.
Indigenous maize varieties from eastern North America have played an outsized role in breeding programs, yet their early origins are not fully understood. We generated paleogenomic data to reconstruct how maize first reached this region and...
Hye Jin Kang,Brian E Krumm,Adrien Tassou et al.
Hye Jin Kang et al.
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remotely controlling cellular signaling, neural activity, behavior, and physiology. Using a structure-guided approach, we provide a peripherally...
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages [0.03%]
人类胎儿胰腺干细胞的长期体外培养可生成所有三种胰岛细胞系
Amanda Andersson-Rolf,Kelvin Groot,Jeroen Korving et al.
Amanda Andersson-Rolf et al.
The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive from a transient, common pan...
Alessandra Dall&#x;Agnese,Ming M Zheng,Shannon Moreno et al.
Alessandra Dall&#x;Agnese et al.
The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent syndromes associated with pathogenic signaling, such as diabetes and chronic inflammation, where our understanding is more limite...