Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex [0.03%]
广谱哈奇曼抗噬菌体防御复合物的基因组完整性感应机制
Owen T Tuck,Benjamin A Adler,Emily G Armbruster et al.
Owen T Tuck et al.
Hachiman is a broad-spectrum antiphage defense system of unknown function. We show here that Hachiman is a heterodimeric nuclease-helicase complex, HamAB. HamA, previously a protein of unknown function, is the effector nuclease. HamB is the...
Xin Hou,Yong He,Pan Fang et al.
Xin Hou et al.
Current metagenomic tools can fail to identify highly divergent RNA viruses. We developed a deep learning algorithm, termed LucaProt, to discover highly divergent RNA-dependent RNA polymerase (RdRP) sequences in 10,487 metatranscriptomes ge...
Retraction notice to: hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage [0.03%]
撤销论文：hnRNP K：HDM2靶点及DNA损伤反应中p53的转录共激活因子
Abdeladim Moumen,Philip Masterson,Mark J O&#x;Connor et al.
Abdeladim Moumen et al.
Retraction of Publication
Cell. 2024 Oct 31;187(22):6413. DOI:10.1016/j.cell.2024.10.008 2024
Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition [0.03%]
TnsABCDF易位子的结构揭示了靶向DNA转座的机制
Shukun Wang,Romana Siddique,Mark C Hall et al.
Shukun Wang et al.
Tn7-like transposons are characterized by their ability to insert specifically into host chromosomes. Recognition of the attachment (att) site by TnsD recruits the TnsABC proteins to form the transpososome and facilitate transposition. Alth...
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification [0.03%]
一种强力的泛sarbecovirus中和抗体，能够抵抗表位多样化
Laura E Rosen,M Alejandra Tortorici,Anna De Marco et al.
Laura E Rosen et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neu...
Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer [0.03%]
人类胰腺癌中由重复RNA引起细胞可塑性破坏的作用机制研究
Eunae You,Patrick Danaher,Chenyue Lu et al.
Eunae You et al.
Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimics viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To better understand the relationship of r...
Guojun Wu,Ting Xu,Naisi Zhao et al.
Guojun Wu et al.
The gut microbiota is crucial for human health, functioning as a complex adaptive system akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems biology tenet that stable relationships signify core comp...
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis [0.03%]
肺驻留的肺泡巨噬细胞调控乳腺癌转移的时间
Erica Dalla,Michael Papanicolaou,Matthew D Park et al.
Erica Dalla et al.
Breast disseminated cancer cells (DCCs) can remain dormant in the lungs for extended periods, but the mechanisms limiting their expansion are not well understood. Research indicates that tissue-resident alveolar macrophages suppress breast ...
Huan Zhao,Zixin Liu,Hui Chen et al.
Huan Zhao et al.
Cellular senescence plays critical roles in aging, regeneration, and disease; yet, the ability to discern its contributions across various cell types to these biological processes remains limited. In this study, we generated an in vivo gene...
Onyou Nam,Sabina Musiał,Manon Demulder et al.
Onyou Nam et al.
Diatoms are central to the global carbon cycle. At the heart of diatom carbon fixation is an overlooked organelle called the pyrenoid, where concentrated CO2 is delivered to densely packed Rubisco. Diatom pyrenoids fix approximately one-fif...