Digital phenotyping from wearables using AI characterizes psychiatric disorders and identifies genetic associations [0.03%]
使用人工智能从可穿戴设备进行数字表型鉴定精神疾病和识别基因关联
Jason J Liu,Beatrice Borsari,Yunyang Li et al.
Jason J Liu et al.
Psychiatric disorders are influenced by genetic and environmental factors. However, their study is hindered by limitations on precisely characterizing human behavior. New technologies such as wearable sensors show promise in surmounting the...
Synthetic organizer cells guide development via spatial and biochemical instructions [0.03%]
合成组织细胞通过空间和生化指令引导发育过程
Toshimichi Yamada,Coralie Trentesaux,Jonathan M Brunger et al.
Toshimichi Yamada et al.
In vitro development relies primarily on treating progenitor cells with media-borne morphogens and thus lacks native-like spatial information. Here, we engineer morphogen-secreting organizer cells programmed to self-assemble, via cell adhes...
Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer [0.03%]
泛癌分析发现肿瘤抑制基因的双等位基因失活，KEAP1纯合子缺失可作为肺癌预测生物标志物
Mark Zucker,Maria A Perry,Samuel I Gould et al.
Mark Zucker et al.
The canonical model of tumor suppressor gene (TSG)-mediated oncogenesis posits that loss of both alleles is necessary for inactivation. Here, through allele-specific analysis of sequencing data from 48,179 cancer patients, we define the pre...
Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes [0.03%]
Crimean-Congo出血热病毒糖蛋白复合物的工程和结构
Elizabeth McFadden,Stephanie R Monticelli,Albert Wang et al.
Elizabeth McFadden et al.
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tickborne virus that can cause severe disease in humans with case fatality rates of 10%-40%. Although structures of CCHFV glycoproteins GP38 and Gc have provided insights into viral entry a...
Erica L Huey,Josef Turecek,Michelle M Delisle et al.
Erica L Huey et al.
Vibrations are ubiquitous in nature, shaping behavior across the animal kingdom. For mammals, mechanical vibrations acting on the body are detected by mechanoreceptors of the skin and deep tissues and processed by the somatosensory system, ...
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies [0.03%]
YTHDF2促进B细胞恶性肿瘤中的ATP合成和免疫逃逸
Zhenhua Chen,Chengwu Zeng,Lu Yang et al.
Zhenhua Chen et al.
Long-term durable remission in patients with B cell malignancies following chimeric antigen receptor (CAR)-T cell immunotherapy remains unsatisfactory, often due to antigen escape. Malignant B cell transformation and oncogenic growth relies...
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration [0.03%]
间歇性禁食触发器官间通讯以抑制毛囊再生
Han Chen,Chao Liu,Shiyao Cui et al.
Han Chen et al.
Intermittent fasting has gained global popularity for its potential health benefits, although its impact on somatic stem cells and tissue biology remains elusive. Here, we report that commonly used intermittent fasting regimens inhibit hair...
Engineering source-sink relations by prime editing confers heat-stress resilience in tomato and rice [0.03%]
基于工程化源库关系的prime editing使番茄和水稻具备耐热性
Huanchang Lou,Shujia Li,Zihang Shi et al.
Huanchang Lou et al.
A 2°C climate-warming scenario is expected to further exacerbate average crop losses by 3%-13%, yet few heat-tolerant staple-crop varieties are available toward meeting future food demands. Here, we develop high-efficiency prime-editing to...
Giulia Irene Maria Pasquesi,Holly Allen,Atma Ivancevic et al.
Giulia Irene Maria Pasquesi et al.
Innate immune signaling is essential for clearing pathogens and damaged cells and must be tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the alternative splicing of exons derived from transposable ele...
How to build the virtual cell with artificial intelligence: Priorities and opportunities [0.03%]
如何利用人工智能建立虚拟细胞：优先项与机遇
Charlotte Bunne,Yusuf Roohani,Yanay Rosen et al.
Charlotte Bunne et al.
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIV...