Luuk Loeff,Alexander Walter,Gian Tizio Rosalen et al.
Luuk Loeff et al.
The detection of molecular patterns associated with invading pathogens is a hallmark of innate immune systems. Prokaryotes deploy sophisticated host defense mechanisms in innate anti-phage immunity. Shedu is a single-component defense syste...
Configuration of electrical synapses filters sensory information to drive behavioral choices [0.03%]
配置电气突触以筛选感觉信息从而驱动行为选择
Agustin Almoril-Porras,Ana C Calvo,Longgang Niu et al.
Agustin Almoril-Porras et al.
Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulat...
Xuan Zhang,Ziliang Luo,Alexandre P Marand et al.
Xuan Zhang et al.
Cis-regulatory elements (CREs) precisely control spatiotemporal gene expression in cells. Using a spatially resolved single-cell atlas of gene expression with chromatin accessibility across ten soybean tissues, we identified 103 distinct ce...
Nucleocapsid assembly drives Ebola viral factory maturation and dispersion [0.03%]
核衣壳组装驱动埃博拉病毒复制工厂的成熟和扩散
Melina Vallbracht,Bianca S Bodmer,Konstantin Fischer et al.
Melina Vallbracht et al.
Replication and genome encapsidation of many negative-sense RNA viruses take place in virus-induced membraneless organelles termed viral factories (VFs). Although liquid properties of VFs are believed to control the transition from genome r...
Jinli Chen,Yanwei Duan,Yuanyuan Zhou et al.
Jinli Chen et al.
ATP-binding cassette (ABC) transporter subfamily H is only identified in arthropods and zebrafish. It transports lipids and is related to insecticide resistance. However, the precise mechanisms of its functions remain elusive. Here, we repo...
Perception of a pathogenic signature initiates intergenerational protection [0.03%]
感知病原信号可启动跨世代保护机制
Corinne L Pender,Julian G Dishart,Holly K Gildea et al.
Corinne L Pender et al.
Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism's descendants. Parental infection by the natural C. elegans pathogen Pseudomonas vranovensis induces a protecti...
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites [0.03%]
周期性内质网-细胞膜连接结构在树突中支持远距离钙信号整合
Lorena Benedetti,Ruolin Fan,Aubrey V Weigel et al.
Lorena Benedetti et al.
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over macroscopic distances remain unclear. Here, we discovered a system of periodically arranged ...
Saurav Mallik,Johannes Venezian,Arseniy Lobov et al.
Saurav Mallik et al.
Protein assembly into functional complexes is critical to life's processes. While complex assembly is classically described as occurring between fully synthesized proteins, recent work showed that co-translational assembly is prevalent in h...
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes [0.03%]
炎症会切换淋巴结中初始淋巴细胞进入所需的趋化因子需求
Kevin Y Chen,Marco De Giovanni,Ying Xu et al.
Kevin Y Chen et al.
Sustained lymphocyte migration from blood into lymph nodes (LNs) is important for immune responses. The CC-chemokine receptor-7 (CCR7) ligand CCL21 is required for LN entry but is downregulated during inflammation, and it has been unclear h...
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity [0.03%]
肠道共生原生动物通过塑造肺部免疫决定呼吸系统疾病预后
Kyle Burrows,Louis Ngai,Pailin Chiaranunt et al.
Kyle Burrows et al.
The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut commensal protozoan, Tritrichomonas musculis (T.mu), remotely shapes the lung immune landsca...