Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders [0.03%]
基于TRIM21的分子胶和PROTAC降解剂的选择性降解多聚蛋白
Panrui Lu,Yalong Cheng,Lei Xue et al.
Panrui Lu et al.
Targeted protein degradation (TPD) utilizes molecular glues or proteolysis-targeting chimeras (PROTACs) to eliminate disease-causing proteins by promoting their interaction with E3 ubiquitin ligases. Current TPD approaches are limited by re...
Shanghua Gao,Ada Fang,Yepeng Huang et al.
Shanghua Gao et al.
We envision "AI scientists" as systems capable of skeptical learning and reasoning that empower biomedical research through collaborative agents that integrate AI models and biomedical tools with experimental platforms. Rather than taking h...
Ivan N Zheludev,Robert C Edgar,Maria Jose Lopez-Galiano et al.
Ivan N Zheludev et al.
Here, we describe "obelisks," a class of heritable RNA elements sharing several properties: (1) apparently circular RNA ∼1 kb genome assemblies, (2) predicted rod-like genome-wide secondary structures, and (3) open reading frames encoding ...
Gurkan Mollaoglu,Alexander Tepper,Chiara Falcomatà et al.
Gurkan Mollaoglu et al.
Ovarian cancer is resistant to immunotherapy, and this is influenced by the immunosuppressed tumor microenvironment (TME) dominated by macrophages. Resistance is also affected by intratumoral heterogeneity, whose development is poorly under...
Multiscale organization of neuronal activity unifies scale-dependent theories of brain function [0.03%]
神经活动的多尺度组织统一了大脑功能的尺度依赖理论
Brandon R Munn,Eli J Müller,Itia Favre-Bulle et al.
Brandon R Munn et al.
Brain recordings collected at different resolutions support distinct signatures of neural coding, leading to scale-dependent theories of brain function. Here, we show that these disparate signatures emerge from a heavy-tailed, multiscale fu...
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion [0.03%]
IRGQ介导的MHC I类分子质量控制自噬促进肿瘤免疫逃逸
Lina Herhaus,Uxía Gestal-Mato,Vinay V Eapen et al.
Lina Herhaus et al.
The autophagy-lysosome system directs the degradation of a wide variety of cargo and is also involved in tumor progression. Here, we show that the immunity-related GTPase family Q protein (IRGQ), an uncharacterized protein to date, acts in ...
Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch [0.03%]
基于结构的胆汁酸衍生物发现及其治疗肝病而不引起瘙痒的作用机制研究
Jun Yang,Tianjun Zhao,Junping Fan et al.
Jun Yang et al.
Chronic itch is a debilitating symptom profoundly impacting the quality of life in patients with liver diseases like cholestasis. Activation of the human G-protein coupled receptor, MRGPRX4 (hX4), by bile acids (BAs) is implicated in promot...
An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania [0.03%]
大洋洲原住民中一种古老的HLA-I类受体等位基因可分化自然杀伤细胞驱动的免疫系统
Liyen Loh,Philippa M Saunders,Camilla Faoro et al.
Liyen Loh et al.
Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors ...
Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration [0.03%]
干细胞活性调控内源性逆转录病毒抑制调控成体组织再生
Ying Lyu,Soo Jin Kim,Ericka S Humphrey et al.
Ying Lyu et al.
Mammalian retrotransposons constitute 40% of the genome. During tissue regeneration, adult stem cells coordinately repress retrotransposons and activate lineage genes, but how this coordination is controlled is poorly understood. Here, we o...
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques [0.03%]
融合肽预处理的SHIV感染猴体内的强效广谱HIV-1中和抗体响应
Hua Wang,Cheng Cheng,James L Dal Santo et al.
Hua Wang et al.
An antibody-based HIV-1 vaccine will require the induction of potent cross-reactive HIV-1-neutralizing responses. To demonstrate feasibility toward this goal, we combined vaccination targeting the fusion-peptide site of vulnerability with i...