Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation [0.03%]
类似胶质的味觉细胞介导周边甜味适应的细胞间模式
Gha Yeon Park,Geehyun Lee,Jongmin Yoon et al.
Gha Yeon Park et al.
The sense of taste generally shows diminishing sensitivity to prolonged sweet stimuli, referred to as sweet adaptation. Yet, its mechanistic landscape remains incomplete. Here, we report that glia-like type I cells provide a distinct mode o...
The Arabidopsis blue-light photoreceptor CRY2 is active in darkness to inhibit root growth [0.03%]
拟南芥蓝光受体CRY2在黑暗中活性化以抑制根系生长
Desheng Zeng,Junqing Lv,Xu Li et al.
Desheng Zeng et al.
Cryptochromes (CRYs) are blue-light receptors that regulate diverse aspects of plant growth. However, whether and how non-photoexcited CRYs function in darkness or non-blue-light conditions is unknown. Here, we show that CRY2 affects the Ar...
The single-molecule accessibility landscape of newly replicated mammalian chromatin [0.03%]
新复制的哺乳动物染色质的单分子可及性景观
Megan S Ostrowski,Marty G Yang,Colin P McNally et al.
Megan S Ostrowski et al.
We present replication-aware single-molecule accessibility mapping (RASAM), a method to nondestructively measure replication status and protein-DNA interactions on chromatin genome-wide. Using RASAM, we uncover a genome-wide state of single...
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice [0.03%]
应激通过破坏侧杏仁体中的记忆痕迹神经元群体来泛化威胁性记忆（小鼠）
Sylvie L Lesuis,Sungmo Park,Annelies Hoorn et al.
Sylvie L Lesuis et al.
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons active during an event (an engram ensemble). We examined the molecular and circuit processes m...
Functional genomics of human skeletal development and the patterning of height heritability [0.03%]
人类骨骼发育的功能基因组学及身高的遗传模式
Daniel Richard,Pushpanathan Muthuirulan,Mariel Young et al.
Daniel Richard et al.
Underlying variation in height are regulatory changes to chondrocytes, cartilage cells comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation and gene expression of chondrocytes sampled across the human sk...
STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair [0.03%]
STK19促进转录偶联DNA修复过程中停滞的RNAPII清除
Diana van den Heuvel,Marta Rodríguez-Martínez,Paula J van der Meer et al.
Diana van den Heuvel et al.
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and transcription factor IIH (TFIIH) arou...
STK19 positions TFIIH for cell-free transcription-coupled DNA repair [0.03%]
STK19在无细胞转录偶联的DNA修复中定位TFIIH蛋白复合体
Tycho E T Mevissen,Maximilian Kümmecke,Ernst W Schmid et al.
Tycho E T Mevissen et al.
In transcription-coupled nucleotide excision repair (TC-NER), stalled RNA polymerase II (RNA Pol II) binds CSB and CRL4CSA, which cooperate with UVSSA and ELOF1 to recruit TFIIH. To explore the mechanism of TC-NER, we recapitulated this rea...
Yu Ding,Boxun Lu
Yu Ding
Targeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate a protein of interest. Emerging technologies are opening avenues in drug discovery and functional characterization of intrac...
Divyanshu Tiwari,Nabarun Roy,Arun K Shukla
Divyanshu Tiwari
In a recently published article in Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporter-like domain with a seven...
Discovery and significance of protein-protein interactions in health and disease [0.03%]
蛋白质相互作用的发现及其在健康和疾病中的意义
Jack F Greenblatt,Bruce M Alberts,Nevan J Krogan
Jack F Greenblatt
The identification of individual protein-protein interactions (PPIs) began more than 40 years ago, using protein affinity chromatography and antibody co-immunoprecipitation. As new technologies emerged, analysis of PPIs increased to a genom...