Hye Jin Kang,Brian E Krumm,Adrien Tassou et al.
Hye Jin Kang et al.
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remotely controlling cellular signaling, neural activity, behavior, and physiology. Using a structure-guided approach, we provide a peripherally...
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages [0.03%]
人类胎儿胰腺干细胞的长期体外培养可生成所有三种胰岛细胞系
Amanda Andersson-Rolf,Kelvin Groot,Jeroen Korving et al.
Amanda Andersson-Rolf et al.
The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive from a transient, common pan...
Alessandra Dall&#x;Agnese,Ming M Zheng,Shannon Moreno et al.
Alessandra Dall&#x;Agnese et al.
The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent syndromes associated with pathogenic signaling, such as diabetes and chronic inflammation, where our understanding is more limite...
Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses [0.03%]
基于 trellis 树的分析揭示了基质对患者衍生类器官药物反应的调节作用
María Ramos Zapatero,Alexander Tong,James W Opzoomer et al.
María Ramos Zapatero et al.
Published Erratum
Cell. 2024 Dec 12;187(25):7335-7349. DOI:10.1016/j.cell.2024.11.023 2024
Mechano-dependent sorbitol accumulation supports biomolecular condensate [0.03%]
力学依赖性的山梨醇积累支持生物分子凝聚体
Stephanie Torrino,William M Oldham,Andrés R Tejedor et al.
Stephanie Torrino et al.
Condensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored. Increasing our understanding of these mechanisms is paramount, as failure to control cond...
ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization [0.03%]
ACSL4和多不饱和脂质支持转移性血管外渗和定植
Yuqi Wang,Mangze Hu,Jian Cao et al.
Yuqi Wang et al.
Metastatic dissemination to distant organs demands that cancer cells possess high morphological and metabolic adaptability. However, contributions of the cellular lipidome to metastasis remain elusive. Here, we uncover a correlation between...
Atlas of the plasma proteome in health and disease in 53,026 adults [0.03%]
53,026名成人健康与疾病状态下血浆蛋白组的图谱
Yue-Ting Deng,Jia You,Yu He et al.
Yue-Ting Deng et al.
Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-...
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification [0.03%]
通过转录组范围的snoRNA靶点识别揭示的小分子核仁rna介导的蛋白质分泌机制研究
Bei Liu,Tong Wu,Bernadette A Miao et al.
Bei Liu et al.
Small nucleolar RNAs (snoRNAs) are non-coding RNAs known for guiding RNA modifications, including 2'-O-methylation (Nm) and pseudouridine (Ψ). While snoRNAs may also interact with other RNAs, such as mRNA, the full repertoire of RNAs targe...
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems [0.03%]
褐藻作为沿海生态系统关键成分的基因组起源研究
France Denoeud,Olivier Godfroy,Corinne Cruaud et al.
France Denoeud et al.
Brown seaweeds are keystone species of coastal ecosystems, often forming extensive underwater forests, and are under considerable threat from climate change. In this study, analysis of multiple genomes has provided insights across the entir...
Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer [0.03%]
肺癌中的成纤维网状细胞可生成保护性的肿瘤内T细胞微环境
Lucas Onder,Chrysa Papadopoulou,Almut Lütge et al.
Lucas Onder et al.
Stringent control of T cell activity in the tumor microenvironment is essential for the generation of protective antitumor immunity. However, the identity, differentiation, and functions of the cells that create critical fibroblastic niches...