Engineering source-sink relations by prime editing confers heat-stress resilience in tomato and rice [0.03%]
基于工程化源库关系的prime editing使番茄和水稻具备耐热性
Huanchang Lou,Shujia Li,Zihang Shi et al.
Huanchang Lou et al.
A 2°C climate-warming scenario is expected to further exacerbate average crop losses by 3%-13%, yet few heat-tolerant staple-crop varieties are available toward meeting future food demands. Here, we develop high-efficiency prime-editing to...
Giulia Irene Maria Pasquesi,Holly Allen,Atma Ivancevic et al.
Giulia Irene Maria Pasquesi et al.
Innate immune signaling is essential for clearing pathogens and damaged cells and must be tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the alternative splicing of exons derived from transposable ele...
How to build the virtual cell with artificial intelligence: Priorities and opportunities [0.03%]
如何利用人工智能建立虚拟细胞：优先项与机遇
Charlotte Bunne,Yusuf Roohani,Yanay Rosen et al.
Charlotte Bunne et al.
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIV...
Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory [0.03%]
人脑海马CA3区使用特定功能连接规则以实现高效联想记忆
Jake F Watson,Victor Vargas-Barroso,Rebecca J Morse-Mora et al.
Jake F Watson et al.
Our brain has remarkable computational power, generating sophisticated behaviors, storing memories over an individual's lifetime, and producing higher cognitive functions. However, little of our neuroscience knowledge covers the human brain...
Transposable element exonization generates a reservoir of evolving and functional protein isoforms [0.03%]
可移动元件的外显子化产生了进化中的功能性蛋白质异构体的一系列新产物
Yago A Arribas,Blandine Baudon,Maxime Rotival et al.
Yago A Arribas et al.
Alternative splicing enhances protein diversity in different ways, including through exonization of transposable elements (TEs). Recent transcriptomic analyses identified thousands of unannotated spliced transcripts with exonizing TEs, but ...
Bibekananda Sahoo,Zongjun Mou,Wei Liu et al.
Bibekananda Sahoo et al.
Ninjurin-1 (NINJ1) is an active executioner of plasma membrane rupture (PMR), a process previously thought to be a passive osmotic lysis event in lytic cell death. Ninjurin-2 (NINJ2) is a close paralog of NINJ1 but cannot mediate PMR. Using...
Benedikt Goretzki,Maryam Khoshouei,Martin Schröder et al.
Benedikt Goretzki et al.
Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin l...
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor [0.03%]
一种常见的人PCSK9基因变异通过LRP1受体促进乳腺癌转移
Wenbin Mei,Schayan Faraj Tabrizi,Christopher Godina et al.
Wenbin Mei et al.
Identifying patients at risk for metastatic relapse is a critical medical need. We identified a common missense germline variant in proprotein convertase subtilisin/kexin type 9 (PCSK9) (rs562556, V474I) that is associated with reduced surv...
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing [0.03%]
利用逆行追踪法表征并靶向胶质母细胞瘤神经-肿瘤网络
Svenja K Tetzlaff,Ekin Reyhan,Nikolas Layer et al.
Svenja K Tetzlaff et al.
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma synapses have been shown to promote glioblastoma progression. However, a characterization of tumor-connected neurons has been hampered by a lack of t...
Jazmín Ramos-Madrigal,Gayle J Fritz,Bryon Schroeder et al.
Jazmín Ramos-Madrigal et al.
Indigenous maize varieties from eastern North America have played an outsized role in breeding programs, yet their early origins are not fully understood. We generated paleogenomic data to reconstruct how maize first reached this region and...