Extensive N4 cytosine methylation is essential for Marchantia sperm function [0.03%]
N4 岛状胞嘧啶甲基化对地钱精子功能至关重要
James Walker,Jingyi Zhang,Yalin Liu et al.
James Walker et al.
N4-methylcytosine (4mC) is an important DNA modification in prokaryotes, but its relevance and even its presence in eukaryotes have been mysterious. Here we show that spermatogenesis in the liverwort Marchantia polymorpha involves two waves...
Engineered nucleocytosolic vehicles for loading of programmable editors [0.03%]
用于装载可编程编辑器的工程化核质运输载体
Julian Geilenkeuser,Niklas Armbrust,Emily Steinmaßl et al.
Julian Geilenkeuser et al.
Advanced gene editing methods have accelerated biomedical discovery and hold great therapeutic promise, but safe and efficient delivery of gene editors remains challenging. In this study, we present a virus-like particle (VLP) system featur...
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals [0.03%]
快速、准确且功能强大的数据分析平台，用于量化分子时空信号
Xuelong Mi,Alex Bo-Yuan Chen,Daniela Duarte et al.
Xuelong Mi et al.
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challe...
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage [0.03%]
自噬诱导的溶酶体损伤限制静息细胞再激活
Andrew Murley,Ann Catherine Popovici,Xiwen Sophie Hu et al.
Andrew Murley et al.
To maintain tissue homeostasis, many cells reside in a quiescent state until prompted to divide. The reactivation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfolded protein ...
Human proteome distribution atlas for tissue-specific plasma proteome dynamics [0.03%]
人体组织特异性血浆蛋白组动态分布图谱
Erik Malmström,Lars Malmström,Simon Hauri et al.
Erik Malmström et al.
The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed...
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures [0.03%]
通过肌肉乙酰胆碱受体结构阐明自身免疫机制
Huanhuan Li,Minh C Pham,Jinfeng Teng et al.
Huanhuan Li et al.
Skeletal muscle contraction is triggered by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at neuromuscular junctions. In myasthenia gravis (MG), autoantibodies target AChRs, disrupting neurotransmission and causing muscle ...
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB [0.03%]
全脑免疫受体图谱鉴定出IL-17E及其受体IL-17RB的神经调节作用
Yunjin Lee,Tomoe Ishikawa,Hyeseung Lee et al.
Yunjin Lee et al.
Cytokines interact with their receptor complexes to orchestrate diverse processes-from immune responses to behavioral modulation. Interleukin-17A (IL-17A) mediates protective immune responses by binding to IL-17 receptor A (IL-17RA) and IL-...
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety [0.03%]
炎症性和抗炎性细胞因子双向调节控制焦虑的杏仁核环路
Byeongjun Lee,Jeong-Tae Kwon,Yire Jeong et al.
Byeongjun Lee et al.
Patients with autoimmune or infectious diseases can develop persistent mood alterations after inflammatory episodes. Peripheral immune molecules, like cytokines, can influence behavioral and internal states, yet their impact on the function...
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution [0.03%]
外周神经系统中的类小胶质细胞跨进化调节神经元胞体大小
Zhisheng Wu,Yiheng Wang,Wei-Wei Chen et al.
Zhisheng Wu et al.
Microglia, essential in the central nervous system (CNS), were historically considered absent from the peripheral nervous system (PNS). Here, we show a PNS-resident macrophage population that shares transcriptomic and epigenetic profiles as...
Channel synapse mediates neurotransmission of airway protective chemoreflexes [0.03%]
气道保护化学反射的神经递质传递由通道型突触介导
Shogo Soma,Norihito Hayatsu,Kengo Nomura et al.
Shogo Soma et al.
Neural reflexes to chemicals in the throat protect the airway from aspiration and infection. Mechanistic understanding of these reflexes remains premature, exemplified by chronic cough-a sensitized cough reflex-being a prevalent unmet clini...