Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells [0.03%]
由细胞外囊泡介导的Gasdermin孔道移植使旁观者细胞发生焦亡
Skylar S Wright,Puja Kumari,Víctor Fraile-Ágreda et al.
Skylar S Wright et al.
Pyroptosis mediated by gasdermins (GSDMs) plays crucial roles in infection and inflammation. Pyroptosis triggers the release of inflammatory molecules, including damage-associated molecular patterns (DAMPs). However, the consequences of pyr...
Nils Burger,Melanie J Mittenbühler,Haopeng Xiao et al.
Nils Burger et al.
Zinc is an essential micronutrient that regulates a wide range of physiological processes, most often through zinc binding to protein cysteine residues. Despite being critical for modulation of protein function, the cysteine sites in the ma...
Global organelle profiling reveals subcellular localization and remodeling at proteome scale [0.03%]
全局细胞器分析揭示了蛋白质组规模的亚细胞定位和重构现象
Marco Y Hein,Duo Peng,Verina Todorova et al.
Marco Y Hein et al.
Defining the subcellular distribution of all human proteins and their remodeling across cellular states remains a central goal in cell biology. Here, we present a high-resolution strategy to map subcellular organization using organelle immu...
Luuk Loeff,Alexander Walter,Gian Tizio Rosalen et al.
Luuk Loeff et al.
The detection of molecular patterns associated with invading pathogens is a hallmark of innate immune systems. Prokaryotes deploy sophisticated host defense mechanisms in innate anti-phage immunity. Shedu is a single-component defense syste...
Configuration of electrical synapses filters sensory information to drive behavioral choices [0.03%]
配置电气突触以筛选感觉信息从而驱动行为选择
Agustin Almoril-Porras,Ana C Calvo,Longgang Niu et al.
Agustin Almoril-Porras et al.
Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulat...
Xuan Zhang,Ziliang Luo,Alexandre P Marand et al.
Xuan Zhang et al.
Cis-regulatory elements (CREs) precisely control spatiotemporal gene expression in cells. Using a spatially resolved single-cell atlas of gene expression with chromatin accessibility across ten soybean tissues, we identified 103 distinct ce...
Nucleocapsid assembly drives Ebola viral factory maturation and dispersion [0.03%]
核衣壳组装驱动埃博拉病毒复制工厂的成熟和扩散
Melina Vallbracht,Bianca S Bodmer,Konstantin Fischer et al.
Melina Vallbracht et al.
Replication and genome encapsidation of many negative-sense RNA viruses take place in virus-induced membraneless organelles termed viral factories (VFs). Although liquid properties of VFs are believed to control the transition from genome r...
Jinli Chen,Yanwei Duan,Yuanyuan Zhou et al.
Jinli Chen et al.
ATP-binding cassette (ABC) transporter subfamily H is only identified in arthropods and zebrafish. It transports lipids and is related to insecticide resistance. However, the precise mechanisms of its functions remain elusive. Here, we repo...
Perception of a pathogenic signature initiates intergenerational protection [0.03%]
感知病原信号可启动跨世代保护机制
Corinne L Pender,Julian G Dishart,Holly K Gildea et al.
Corinne L Pender et al.
Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism's descendants. Parental infection by the natural C. elegans pathogen Pseudomonas vranovensis induces a protecti...
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites [0.03%]
周期性内质网-细胞膜连接结构在树突中支持远距离钙信号整合
Lorena Benedetti,Ruolin Fan,Aubrey V Weigel et al.
Lorena Benedetti et al.
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over macroscopic distances remain unclear. Here, we discovered a system of periodically arranged ...