Emily Forster,Xinyin Wang,Abenan Thayaparan et al.
Emily Forster et al.
Human fertilization is a complex, highly regulated process that involves intricate molecular interactions between sperm and egg. Ultimately, this process culminates in the fusion of the gamete membranes to form a zygote. Gene disruption stu...
An-Hui Ge,Ertao Wang
An-Hui Ge
The advent of semi-dwarf crop varieties and fertilizers during the Green Revolution boosted yields and food security. However, unintended consequences such as environmental pollution and greenhouse gas emissions underscore the need for stra...
Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk [0.03%]
具有溢出风险的利用ACE2受体的MERS相关冠状病毒的全球监测与对策
Shibo Jiang,Fan Wu
Shibo Jiang
Three studies published in this issue of Cell reveal that multiple MERS-related coronaviruses (MERSr-CoVs) utilize ACE2, rather than the canonical Merbecovirus receptor DPP4, for cell entry. These ACE2-dependent MERSr-CoVs pose a risk of zo...
Marni J Falk
Marni J Falk
In this issue of Cell, Blume et al. provide compelling rationale for pursuing pharmacologic optimization of a small-molecule "HypoxyStat," which left-shifts the oxyhemoglobin dissociation curve in red blood cells in an attempt to induce an ...
Lai Guan Ng,Immanuel Kwok
Lai Guan Ng
Neutrophils secrete a variety of mediators throughout their lifespan but are mostly associated with pro-inflammatory functions. In this issue of Cell, Hsu et al. describe a new class of extracellular vesicles produced solely by aged neutrop...
Tomotsune Ameku,Anna Laddach,Hannah Beckwith et al.
Tomotsune Ameku et al.
The organs of many female animals are remodeled by reproduction. Using the mouse intestine, a striking and tractable model of organ resizing, we find that reproductive remodeling is anticipatory and distinct from diet- or microbiota-induced...
Kian Hong Kock,Le Min Tan,Kyung Yeon Han et al.
Kian Hong Kock et al.
The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell RN...
Jumbo phage killer immune system targets early infection of nucleus-forming phages [0.03%]
巨型噬菌体免疫系统针对核形成噬菌体的早期感染目标
Li Yuping,Linlin Guan,Isabelle Becher et al.
Li Yuping et al.
Jumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and a proteinaceous nucleus-like structure during infection. These structures protect the phage from nucleases and may create selective ...
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay [0.03%]
因胰岛素mRNA降解加速而来自遗传方面的一型糖尿病防护效应
René van Tienhoven,Denis O&#x;Meally,Tristan A Scott et al.
René van Tienhoven et al.
Insulin gene (INS) variation and beta-cell stress are associated with the risk of development of type 1 diabetes (T1D) and autoimmunity against insulin. The unfolded protein response alleviating endoplasmic reticulum (ER) stress involves ac...
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs [0.03%]
配体诱导的泛素化通过阻碍信号基序的膜隔离来释放LAG3免疫检查点功能
Yong Jiang,Anran Dai,Yuwei Huang et al.
Yong Jiang et al.
Lymphocyte activation gene 3 (LAG3) has emerged as a promising cancer immunotherapy target, but the mechanism underlying LAG3 activation upon ligand engagement remains elusive. Here, LAG3 was found to undergo robust non-K48-linked polyubiqu...