Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease [0.03%]
长体细胞DNA重复序列扩增驱动亨廷顿舞蹈病神经退行性病变
Robert E Handsaker,Seva Kashin,Nora M Reed et al.
Robert E Handsaker et al.
In Huntington's disease (HD), striatal projection neurons (SPNs) degenerate during midlife; the core biological question involves how the disease-causing DNA repeat (CAG)n in the huntingtin (HTT) gene leads to neurodegeneration after decade...
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women [0.03%]
青少年和年轻女性中宫颈阴道菌群与沙眼衣原体的自然病程关系研究
Mykhaylo Usyk,Luke Carlson,Nicolas F Schlecht et al.
Mykhaylo Usyk et al.
This study investigated the cervicovaginal microbiome's (CVM's) impact on Chlamydia trachomatis (CT) infection among Black and Hispanic adolescent and young adult women. A total of 187 women with incident CT were matched to 373 controls, an...
Nicola L Harris,Benjamin J Marsland
Nicola L Harris
The gut microbiota is a powerful influencer of systemic immunity, with its impact on distal organs like the lungs garnering increasing attention. In this issue of Cell, Burrows et al. report that a gut protozoan plays a key role in shaping ...
Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution [0.03%]
染色体片段连续断裂重塑骨肉瘤的肿瘤图谱
Jose Espejo Valle-Inclan,Solange De Noon,Katherine Trevers et al.
Jose Espejo Valle-Inclan et al.
Osteosarcoma is the most common primary cancer of the bone, with a peak incidence in children and young adults. Using multi-region whole-genome sequencing, we find that chromothripsis is an ongoing mutational process, occurring subclonally ...
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies [0.03%]
横跨不同祖先的抑郁症全基因组研究鉴定出697种关联，涉及细胞类型和药物治疗
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 loci, 293 of which...
Direct visualization of electric-field-stimulated ion conduction in a potassium channel [0.03%]
直接观察电场刺激下的钾通道离子导电性
BoRam Lee,K Ian White,Michael Socolich et al.
BoRam Lee et al.
Understanding protein function would be facilitated by direct, real-time observation of chemical kinetics in the atomic structure. The selectivity filter (SF) of the K+ channel provides an ideal model, catalyzing the dehydration and transpo...
Selective excitation of bacteria enables growth suppression without antibiotics [0.03%]
选择性激发细菌实现无需抗生素的抑菌效果
Michael W Chen,Yifan Dai
Michael W Chen
In a recently published article in Device, Saehyun Kim et al. report that selective excitation of bacteria can inhibit their proliferation in an antibiotic-free manner. We herein discuss the molecular and thermodynamic principles underlying...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep [0.03%]
睡眠期间去甲肾上腺素介导的慢血管运动驱动淋巴介导的清除作用
Natalie L Hauglund,Mie Andersen,Klaudia Tokarska et al.
Natalie L Hauglund et al.
As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic removal of waste products, are activated. Yet, it is not known what drives brain clearance dur...
Matthew K Howard,Nicholas Hoppe,Xi-Ping Huang et al.
Matthew K Howard et al.
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-electron microsco...
Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4 [0.03%]
基于结构的非洲爪蟾G蛋白偶联受体4和小鼠G蛋白耦联受体4质子感应机制研究
Xin Wen,Pan Shang,Haidi Chen et al.
Xin Wen et al.
Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monitor pH changes related to their physiology and generate adaptive reactions. However, the evolutionary trajectory and structural mechanis...