Side Hu,Heesu Kim,Pan Yang et al.
Side Hu et al.
Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans. The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a promising drug target. We determined the cryoelectron microsc...
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation [0.03%]
通过Mettl3-Mettl14-Dnmt1轴微调基因表达控制多能干细胞分化
Giuseppe Quarto,Andrea Li Greci,Martin Bizet et al.
Giuseppe Quarto et al.
The marking of DNA, histones, and RNA is central to gene expression regulation in development and disease. Recent evidence links N6-methyladenosine (m6A), installed on RNA by the METTL3-METTL14 methyltransferase complex, to histone modifica...
Jan Philipp Kreysing,Maziar Heidari,Vojtech Zila et al.
Jan Philipp Kreysing et al.
Upon infection, human immunodeficiency virus type 1 (HIV-1) releases its cone-shaped capsid into the cytoplasm of infected T cells and macrophages. The capsid enters the nuclear pore complex (NPC), driven by interactions with numerous pheny...
Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients [0.03%]
专用于难治性肿瘤患者的条件复制溶瘤病毒治疗的临床试验
Liping Zhong,Lu Gan,Bing Wang et al.
Liping Zhong et al.
Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies. However, intravenous safety and inherent lack of immunity are two significant limitations in clinical practice. Herein, we successfully developed a rec...
SMC motor proteins extrude DNA asymmetrically and can switch directions [0.03%]
SMC蛋白酶不对称地排出DNA且可以转换方向
Roman Barth,Iain F Davidson,Jaco van der Torre et al.
Roman Barth et al.
Structural maintenance of chromosomes (SMC) complexes organize the genome via DNA loop extrusion. Although some SMCs were reported to do so symmetrically, reeling DNA from both sides into the extruded DNA loop simultaneously, others perform...
Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution [0.03%]
单细胞分辨率下内胚层器官发育的时空和遗传谱系追踪
Ke-Ran Li,Pei-Long Yu,Qi-Qi Zheng et al.
Ke-Ran Li et al.
During early mammalian development, the endoderm germ layer forms the foundation of the respiratory and digestive systems through complex patterning. This intricate process, guided by a series of cell fate decisions, remains only partially ...
A biophysical basis for the spreading behavior and limited diffusion of Xist [0.03%]
Xist的扩散行为及这种行为受限的机制的生物物理基础
Mingrui Ding,Danni Wang,Hui Chen et al.
Mingrui Ding et al.
Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates th...
Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease [0.03%]
长体细胞DNA重复序列扩增驱动亨廷顿舞蹈病神经退行性病变
Robert E Handsaker,Seva Kashin,Nora M Reed et al.
Robert E Handsaker et al.
In Huntington's disease (HD), striatal projection neurons (SPNs) degenerate during midlife; the core biological question involves how the disease-causing DNA repeat (CAG)n in the huntingtin (HTT) gene leads to neurodegeneration after decade...
Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women [0.03%]
青少年和年轻女性中宫颈阴道菌群与沙眼衣原体的自然病程关系研究
Mykhaylo Usyk,Luke Carlson,Nicolas F Schlecht et al.
Mykhaylo Usyk et al.
This study investigated the cervicovaginal microbiome's (CVM's) impact on Chlamydia trachomatis (CT) infection among Black and Hispanic adolescent and young adult women. A total of 187 women with incident CT were matched to 373 controls, an...
Nicola L Harris,Benjamin J Marsland
Nicola L Harris
The gut microbiota is a powerful influencer of systemic immunity, with its impact on distal organs like the lungs garnering increasing attention. In this issue of Cell, Burrows et al. report that a gut protozoan plays a key role in shaping ...