Bastian Linder,Puneet Sharma,Jie Wu et al.
Bastian Linder et al.
Chemically modified nucleotides in mRNA are critical regulators of gene expression, primarily through interactions with reader proteins that bind to these modifications. Here, we present a mechanism by which the epitranscriptomic mark N6-me...
Global genetic structure of human gut microbiome species is related to geographic location and host health [0.03%]
人类肠道菌群的全球遗传结构与地理位置和宿主健康状况相关
Sergio Andreu-Sánchez,Aitor Blanco-Míguez,Daoming Wang et al.
Sergio Andreu-Sánchez et al.
The human gut harbors thousands of microbial species, each exhibiting significant inter-individual genetic variability. Although many studies have associated microbial relative abundances with human-health-related phenotypes, the substantia...
A natural gene on-off system confers field thermotolerance for grain quality and yield in rice [0.03%]
水稻田间高温抗性自然基因开关型调控系统创制优质高产新品种
Wei Li,Ke Yang,Chaofan Hu et al.
Wei Li et al.
Rising global temperatures threaten crop grain quality and yield; however, how temperature regulates grain quality and how to achieve synergistic thermotolerance for both quality and yield remain unknown. Here, we identified a rice major lo...
Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells [0.03%]
固有杀伤细胞和细胞毒性T细胞对糖脂合成的选择性需求
Tasha A Morrison,Jaelyn Vigee,Kevin A Tovar et al.
Tasha A Morrison et al.
Cell identity genes that exhibit complex regulation are marked by super-enhancer (SE) architecture. Assessment of SEs in natural killer (NK) cells identified Ugcg, encoding the enzyme responsible for glycosphingolipid (GSL) synthesis. Condi...
Macrophages direct location-dependent recall of B cell memory to vaccination [0.03%]
巨噬细胞定位决定B细胞对疫苗接种的免疫记忆反应
Rama Dhenni,Alexandra Carey Hoppé,Arnold Reynaldi et al.
Rama Dhenni et al.
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell receptor upon boosting and re-exposure to antigen. We show in mouse models that lymph nod...
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons [0.03%]
老年痴呆患者来源的高分子量tau损害海马神经元簇状放电
Samuel S Harris,Robert Ellingford,Jana Hartmann et al.
Samuel S Harris et al.
Tau accumulation is closely related to cognitive symptoms in Alzheimer's disease (AD). However, the cellular drivers of tau-dependent decline of memory-based cognition remain elusive. Here, we employed in vivo Neuropixels and patch-clamp re...
Regional differences in progenitor metabolism shape brain growth during development [0.03%]
发育过程中祖细胞代谢的区域差异塑造大脑生长
Natalia Baumann,Robin J Wagener,Awais Javed et al.
Natalia Baumann et al.
Mammals have particularly large forebrains compared with other brain parts, yet the developmental mechanisms underlying this regional expansion remain poorly understood. Here, we provide a single-cell-resolution birthdate atlas of the mouse...
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors [0.03%]
肿瘤中的细胞外染色体DNA复制和维持与DNA损伤通路偶联
Xing Kang,Xinran Li,Jiaqi Zhou et al.
Xing Kang et al.
Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells. However, the functional significance of ecDNA and the molecular components involved in its replication and maintenance remain largely unknown. Here, using CRISPR-C technolog...
Tomotsune Ameku,Anna Laddach,Hannah Beckwith et al.
Tomotsune Ameku et al.
Published Erratum
Cell. 2025 Apr 26:S0092-8674(25)00459-3. DOI:10.1016/j.cell.2025.04.023 2025
Menghan Liu,Sydney B Blattman,Mai Takahashi et al.
Menghan Liu et al.
Published Erratum
Cell. 2025 Apr 25:S0092-8674(25)00453-2. DOI:10.1016/j.cell.2025.04.018 2025