Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3 [0.03%]
支持记忆的海马CA3区神经元动力学机制
Yiding Li,John J Briguglio,Sandro Romani et al.
Yiding Li et al.
Published Erratum
Cell. 2025 Jan 25:S0092-8674(25)00049-2. DOI:10.1016/j.cell.2025.01.020 2025
Ligand interaction landscape of transcription factors and essential enzymes in E. coli [0.03%]
大肠杆菌中转录因子和必需酶的配体相互作用图谱
Hui Peng,Sergei Kotelnikov,Megan E Egbert et al.
Hui Peng et al.
Knowledge of protein-metabolite interactions can enhance mechanistic understanding and chemical probing of biochemical processes, but the discovery of endogenous ligands remains challenging. Here, we combined rapid affinity purification wit...
Designed mosaic nanoparticles enhance cross-reactive immune responses in mice [0.03%]
设计的马赛克型纳米颗粒能够增强小鼠交叉免疫反应
Eric Wang,Alexander A Cohen,Luis F Caldera et al.
Eric Wang et al.
Nanoparticle vaccines displaying combinations of SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) could protect against SARS-CoV-2 variants and spillover of zoonotic sarbecoviruses into humans. Using a computational ...
Comparative proteomic landscapes elucidate human preimplantation development and failure [0.03%]
比较蛋白质组学揭示人类植入前胚胎发育及发育障碍的分子机制
Wencheng Zhu,Juan Meng,Yan Li et al.
Wencheng Zhu et al.
Understanding mammalian preimplantation development, particularly in humans, at the proteomic level remains limited. Here, we applied our comprehensive solution of ultrasensitive proteomic technology to measure the proteomic profiles of ooc...
Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus [0.03%]
成人脑皮层和海马体内源性N-甲基-D天冬氨酸受体的组装与结构
Ming Zhang,Juan Feng,Chun Xie et al.
Ming Zhang et al.
The cerebral cortex and hippocampus are crucial brain regions for learning and memory, which depend on activity-induced synaptic plasticity involving N-methyl-ᴅ-aspartate receptors (NMDARs). However, subunit assembly and molecular architec...
Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation [0.03%]
心脏代谢益处与非工业型饮食有关并由肠道菌群调节所介导
Fuyong Li,Anissa M Armet,Katri Korpela et al.
Fuyong Li et al.
Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a microbiome restoration strategy comprising a diet that recapitulated key characteristics of non-industriali...
Jiawei Wang,Xingyu Ouyang,Shiyu Meng et al.
Jiawei Wang et al.
Biocatalytic cascades with spatial proximity can orchestrate multistep pathways to form metabolic highways, which enhance the overall catalytic efficiency. However, the effect of spatial organization on catalytic activity is poorly understo...
Centromeric chromatin clearings demarcate the site of kinetochore formation [0.03%]
centromere染色质清除域划定着丝粒的位置
Kathryn Kixmoeller,Ekaterina V Tarasovetc,Elie Mer et al.
Kathryn Kixmoeller et al.
The centromere is the chromosomal locus that recruits the kinetochore, directing faithful propagation of the genome during cell division. Using cryo-ET on human mitotic chromosomes, we reveal a distinctive architecture at the centromere: cl...
High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning [0.03%]
基于微流控和迁移学习的复杂组织高分辨率空间分辨蛋白质组学
Beiyu Hu,Ruiqiao He,Kun Pang et al.
Beiyu Hu et al.
Despite recent advances in imaging- and antibody-based methods, achieving in-depth, high-resolution protein mapping across entire tissues remains a significant challenge in spatial proteomics. Here, we present parallel-flow projection and t...
Erez Yirmiya,Samuel J Hobbs,Azita Leavitt et al.
Erez Yirmiya et al.
Viruses encode proteins that inhibit host defenses, but sifting through the millions of available viral sequences for immune-modulatory proteins has been so far impractical. Here, we develop a process to systematically screen virus-encoded ...