Immunotherapy-related cognitive impairment after CAR T cell therapy in mice [0.03%]
嵌合抗原受体T细胞治疗后的免疫疗法相关的认知障碍小鼠模型
Anna C Geraghty,Lehi Acosta-Alvarez,Maria C Rotiroti et al.
Anna C Geraghty et al.
Immunotherapies have revolutionized cancer care for many tumor types, but their potential long-term cognitive impacts are incompletely understood. Here, we demonstrated in mouse models that chimeric antigen receptor (CAR) T cell therapy for...
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity [0.03%]
环二核苷酸诱导的磷脂酶丝状聚合调控广泛的CBASS免疫反应
Jingge Wang,Zhao Li,Hao Lang et al.
Jingge Wang et al.
Cyclic-oligonucleotide-based antiphage signaling systems (CBASS), a widespread antiviral bacterial immune system homologous to the mammalian cGAS-STING pathway, synthesizes cyclic nucleotide signals and triggers effector proteins to induce ...
Robert Frömel,Julia Rühle,Aina Bernal Martinez et al.
Robert Frömel et al.
During cellular differentiation, enhancers transform overlapping gradients of transcription factors (TFs) to highly specific gene expression patterns. However, the vast complexity of regulatory DNA impedes the identification of the underlyi...
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2 [0.03%]
冠状病毒SARS-CoV和SARS-CoV-2的蝙蝠病毒祖先的近期演变及地理起源
Jonathan E Pekar,Spyros Lytras,Mahan Ghafari et al.
Jonathan E Pekar et al.
The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecoviruses, we find that the ...
Zhang Juen,Zhengyuan Lu,Ruihuan Yu et al.
Zhang Juen et al.
In humans, the detection and ultimately the perception of sweetness begin in the oral cavity, where taste receptor cells (TRCs) dedicated to sweet-sensing interact with sugars, artificial sweeteners, and other sweet-tasting chemicals. Human...
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory [0.03%]
组蛋白乳酸化修饰连接代谢和表观遗传重编程促进先天免疫记忆形成
Athanasios Ziogas,Boris Novakovic,Lorenzo Ventriglia et al.
Athanasios Ziogas et al.
Trained immunity, a de facto innate immune memory characterized by enhanced responsiveness to future challenges, is underpinned by epigenetic and metabolic rewiring. In individuals vaccinated with Bacille Calmette-Guérin (BCG), lactate rel...
Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies [0.03%]
蛇毒防御：使用varespladib鸡尾酒和广谱中和的人类抗体进行防护
Jacob Glanville,Mark Bellin,Sergei Pletnev et al.
Jacob Glanville et al.
Snake envenomation is a neglected tropical disease, with 600 species causing over 100,000 deaths and 300,000 permanent disabilities in humans annually. Broadly neutralizing antibodies and broad chemical inhibitors have been proposed as solu...
Isak W Tengesdal,Siddhartha Jaiswal
Isak W Tengesdal
Clonal hematopoiesis of indeterminate potential (CHIP) promotes adverse outcomes in age-related diseases. However, the impact of CHIP on solid tumors has yet to be elucidated in large-scale cancer-focused cohorts. In a recently published ar...
Ye Zhao,Kai W Wucherpfennig
Ye Zhao
The inhibitory receptor LAG3 is the target of the FDA-approved mAb relatlimab, but its mechanism of signaling is not well understood. In this issue of Cell, Jiang et al. demonstrate that ubiquitination of its cytoplasmic domain is essential...
Neural-activity-regulated and glia-mediated control of brain lymphatic development [0.03%]
神经活性调节和胶质细胞介导的脑淋巴管发育控制
Jia Li,Ming-Jian Liu,Wen-Jie Du et al.
Jia Li et al.
The nervous system regulates peripheral immune responses under physiological and pathological conditions, but the brain's impact on immune system development remains unknown. Meningeal mural lymphatic endothelial cells (muLECs), embedded in...