Retooling science: Transforming tools into instruments of equity as a Black physician-scientist [0.03%]
重构科学：作为一名黑人医师科学家，将工具转化为公平正义的工具
Victor Ekuta
Victor Ekuta
Victor Ekuta is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, the experiences that sparked t...
Kenna Gloria Agbugba
Kenna Gloria Agbugba
Kenna Gloria Agbugba is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and goal...
The sounds of music: Tracing memories and pathways through research and resistance [0.03%]
音乐的声音——通过研究与反抗追溯回忆与途径
Jheannelle Johnson
Jheannelle Johnson
Jheannelle Johnson is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences that sparked...
Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation [0.03%]
脑干神经肽能神经元连接一个神经激素轴以产生饱腹感
Srikanta Chowdhury,Nachiket G Kamatkar,Wendy Xueyi Wang et al.
Srikanta Chowdhury et al.
Hunger is evolutionarily hardwired to ensure that an animal has sufficient energy to survive and reproduce. Just as important as knowing when to start eating is knowing when to stop eating. Here, using spatially resolved single-cell phenoty...
Haosheng Shen,Nikhil Aggarwal,Beiming Cui et al.
Haosheng Shen et al.
Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for brain-targeted therapeutic delivery, although its feasibility is hampered by the anatomical and absorptive limitations of the OE. In this study, w...
Rhodoquinone carries electrons in the mammalian electron transport chain [0.03%]
rho醌在哺乳动物电子传递链中负责电子的传输
Jonathan Valeros,Madison Jerome,Tenzin Tseyang et al.
Jonathan Valeros et al.
Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O2). In hypoxia, ubiquinol (UQH2) diverts these electrons onto fum...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation [0.03%]
长期单个核糖体成像揭示了信使RNA翻译中核糖体的协作性
Maximilian F Madern,Sora Yang,Olivier Witteveen et al.
Maximilian F Madern et al.
The genetic information stored in mRNAs is decoded by ribosomes during mRNA translation. mRNAs are typically translated by multiple ribosomes simultaneously, but it is unclear whether and how the activity of different ribosomes on an mRNA i...
Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target [0.03%]
ACE2利用型冠状病毒刺突早期融合中间体作为抗病毒靶点
Lixiao Xing,Zhimin Liu,Xinling Wang et al.
Lixiao Xing et al.
Coronavirus fusion with and entry into the host cell depends on viral spike, which acts as a crucial component of viral infection. However, the lack of receptor-activated spike intermediate conformation has hindered a comprehensive understa...
Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment [0.03%]
解析人类加速区域在人和黑猩猩神经发育过程中的三维互作组
Atreyo Pal,Mark A Noble,Matheo Morales et al.
Atreyo Pal et al.
Human accelerated regions (HARs) have been implicated in human brain evolution. However, insight into the genes and pathways they control is lacking, hindering the understanding of their function. Here, we identify 2,963 conserved gene targ...
Identification, structure, and agonist design of an androgen membrane receptor [0.03%]
雄性激素膜受体的鉴定、结构与激动剂设计
Zhao Yang,Yu-Qi Ping,Ming-Wei Wang et al.
Zhao Yang et al.
Androgens, such as 5α-dihydrotestosterone (5α-DHT), regulate numerous functions by binding to nuclear androgen receptors (ARs) and potential unknown membrane receptors. Here, we report that the androgen 5α-DHT activates membrane receptor...