SecY translocon chaperones protein folding during membrane protein insertion [0.03%]
SecY转运蛋白在膜蛋白插入过程中伴娘蛋白质折叠过程
Xiaomin Ou,Chengying Ma,Dongjie Sun et al.
Xiaomin Ou et al.
The Sec translocon is vital for guiding membrane protein insertion into lipid bilayers. The insertion and folding processes of membrane proteins are poorly understood. Here, we report cryo-electron microscopy structures of multi-spanning me...
Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion [0.03%]
视觉皮层中的运动和前庭信号可以实现自我产生的视觉运动与外部产生的视觉运动的分离
Mateo Vélez-Fort,Lee Cossell,Laura Porta et al.
Mateo Vélez-Fort et al.
Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation pr...
Jacob Parres-Gold,Matthew Levine,Benjamin Emert et al.
Jacob Parres-Gold et al.
Many biological signaling pathways employ proteins that competitively dimerize in diverse combinations. These dimerization networks can perform biochemical computations in which the concentrations of monomer inputs determine the concentrati...
Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor [0.03%]
感染蝙蝠的Merbecovirus HKU5-CoV 血液线2能利用人类ACE2作为细胞受体
Jing Chen,Wei Zhang,Yang Li et al.
Jing Chen et al.
Merbecoviruses comprise four viral species with remarkable genetic diversity: MERS-related coronavirus, Tylonycterisbat coronavirus HKU4, Pipistrellusbat coronavirus HKU5, and Hedgehog coronavirus 1. However, the potential human spillover r...
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins [0.03%]
从RNA毒素-抗毒素系统进化而来的可重新编程的RNA导向CRISPR系统
Shai Zilberzwige-Tal,Han Altae-Tran,Soumya Kannan et al.
Shai Zilberzwige-Tal et al.
Despite ongoing efforts to study CRISPR systems, the evolutionary origins giving rise to reprogrammable RNA-guided mechanisms remain poorly understood. Here, we describe an integrated sequence/structure evolutionary tracing approach to iden...
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity [0.03%]
HypoxyStat，一种提高氧血红蛋白亲和力的低氧治疗小分子形式
Skyler Y Blume,Ankur Garg,Yolanda Martí-Mateos et al.
Skyler Y Blume et al.
We have previously demonstrated that chronic inhaled hypoxia is remarkably therapeutic in the premier animal model of mitochondrial Leigh syndrome, the Ndufs4 knockout (KO) mouse. Subsequent work has extended this finding to additional mito...
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness [0.03%]
乳腺上皮内淋巴细胞促进泌乳及后代健康
Dan Corral,Eduard Ansaldo,Jérémie Delaleu et al.
Dan Corral et al.
Breastfeeding is an obligatory requirement of mammalian survival. This fundamental process is associated with the adaptation of maternal physiology, including the transformation of the mammary gland into a milk-secreting organ. How maternal...
Tom Hindmarsh Sten,Rufei Li,Florian Hollunder et al.
Tom Hindmarsh Sten et al.
Males of many species have evolved behavioral traits to both attract females and repel rivals. Here, we explore mate selection in Drosophila from both the male and female perspective to shed light on how these key components of sexual selec...
Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism [0.03%]
同义突变通过干扰m6A依赖的信使RNA代谢促进肿瘤发生
Yiheng Lan,Zhen Xia,Qizhe Shao et al.
Yiheng Lan et al.
Cancer cells acquire numerous mutations during tumorigenesis, including synonymous mutations that do not change the amino acid sequence of a protein. RNA N6-methyladenosine (m6A) is a post-transcriptional modification that plays critical ro...
Jing-Jing Xu,Yuan Lei,Xiao-Fan Zhang et al.
Jing-Jing Xu et al.
Coenzyme Q (CoQ) is essential for energy production by mitochondrial respiration, and it is a supplement most often used to promote cardiovascular health. Humans make CoQ10, but cereals and some vegetable/fruit crops synthesize CoQ9 with a ...