Cross-organ metabolite production and consumption in healthy and atherogenic conditions [0.03%]
健康和动脉硬化条件下的跨器官代谢物产生和消耗
Hosung Bae,Sunhee Jung,Johnny Le et al.
Hosung Bae et al.
Mammalian organs continuously produce and consume circulating metabolites for organismal health and survival. However, the landscape of this fundamental process and its perturbation by diet and disease is unknown. Using arteriovenous metabo...
Xin Wang,Yuan Liu,Zhenchao Wang et al.
Xin Wang et al.
A universal strategy to precisely control protein activation in living animals is crucial for gain-of-function study of proteins under in vivo settings. We herein report CAGE-Proxvivo, a computer-aided proximal decaging strategy for on-dema...
Personalized molecular signatures of insulin resistance and type 2 diabetes [0.03%]
胰岛素抵抗和2型糖尿病的个性化分子特征
Jeppe Kjærgaard,Ben Stocks,John Henderson et al.
Jeppe Kjærgaard et al.
Insulin resistance is a hallmark of type 2 diabetes, which is a highly heterogeneous disease with diverse pathology. Understanding the molecular signatures of insulin resistance and its association with individual phenotypic traits is cruci...
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses [0.03%]
从头组装核压力体重新排列并增强NFIL3以抑制急性炎症反应
Xiao-Qi Liu,Pan Li,Bao-Qing Gao et al.
Xiao-Qi Liu et al.
The membrane-less nuclear stress bodies (nSBs), with satellite III (SatIII) RNAs as the hallmark, are present in primates upon sensing stresses. We report that SatⅢ DNAs, SatⅢ RNAs, and 30 nSB proteins assemble into well-organized structu...
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates [0.03%]
应激颗粒内TDP-43凝聚物的脱混生成病理聚集体
Xiao Yan,David Kuster,Priyesh Mohanty et al.
Xiao Yan et al.
Cytosolic aggregation of the nuclear protein TAR DNA-binding protein 43 (TDP-43) is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that TDP-43 aggregation req...
Eva Breyer,Constanze Stix,Sophie Kilker et al.
Eva Breyer et al.
Metagenomic analysis has recently unveiled the widespread presence of pelagic fungi in the global ocean, yet their quantitative contribution to carbon stocks remains elusive, hindering their incorporation into biogeochemical models. Here, w...
Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses [0.03%]
近红外时空色彩视觉的人体试验及接触式上转换隐形眼镜
Yuqian Ma,Yunuo Chen,Sheng Wang et al.
Yuqian Ma et al.
Humans cannot perceive infrared light due to the physical thermodynamic properties of photon-detecting opsins. However, the capability to detect invisible multispectral infrared light with the naked eye is highly desirable. Here, we report ...
Jakob Trendel,Simon Trendel,Shuyao Sha et al.
Jakob Trendel et al.
In a human cell, DNA is packed with histones, RNA, and chromatin-associated proteins, forming a cohesive gel. At any given moment, only a subset of the proteome has physical access to the DNA and organizes its structure, transcription, repl...
Inheritance of acquired adaptive cold tolerance in rice through DNA methylation [0.03%]
水稻通过DNA甲基化继承获得性抗寒性
Xianwei Song,Shanjie Tang,Hui Liu et al.
Xianwei Song et al.
Epigenetic pathways could provide a mechanistic explanation for the inheritance of acquired characteristics, as proposed by Lamarck in 1802, but epigenetic alterations that endow adaptive hereditary traits have rarely been observed. Here, i...
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types [0.03%]
一组皮质细胞类型遗传访问的增强子AAV和转基因小鼠系
Yoav Ben-Simon,Marcus Hooper,Sujatha Narayan et al.
Yoav Ben-Simon et al.
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential for understanding its function in health and dis...