Tom Maniatis
Tom Maniatis
NIH's abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes America's global leadership in science and med...
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response [0.03%]
赖氨酸的维生酰化是一种维生素C衍生的蛋白质修饰可增强STAT1介导的免疫反应
Xiadi He,Qiwei Wang,Xin Cheng et al.
Xiadi He et al.
Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer, yet its mechanisms remain elusive. Here, we report that vitC directly modifies lysine residues to form "vitcyl-lysine"-a process termed vitcylation...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry [0.03%]
RNA结合蛋白和glycoRNAs在细胞表面形成域以供细胞穿膜肽进入
Jonathan Perr,Andreas Langen,Karim Almahayni et al.
Jonathan Perr et al.
The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be the major constituents of the external surface of the plasma mem...
The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns [0.03%]
国际空间站由使用模式驱动具有独特和极端的微生物和化学环境
Rodolfo A Salido,Haoqi Nina Zhao,Daniel McDonald et al.
Rodolfo A Salido et al.
Space habitation provides unique challenges in built environments isolated from Earth. We produced a 3D map of the microbes and metabolites throughout the United States Orbital Segment (USOS) of the International Space Station (ISS) with 80...
Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication [0.03%]
裂谷热病毒协调可编程E3连接酶的组装以促进病毒复制
Huiling Li,Yulan Zhang,Guibo Rao et al.
Huiling Li et al.
Published Erratum
Cell. 2025 Feb 22:S0092-8674(25)00193-X. DOI:10.1016/j.cell.2025.02.008 2025
Nicholas A Prescott,Tracy Biaco,Andrés Mansisidor et al.
Nicholas A Prescott et al.
Chronic hepatitis B virus (HBV) infection is an incurable pathogen responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral co...
Plasmodesmata act as unconventional membrane contact sites regulating intercellular molecular exchange in plants [0.03%]
胞间连丝作为非常规的膜接触位点调控着植物细胞间的分子交换
Jessica Pérez-Sancho,Marija Smokvarska,Gwennogan Dubois et al.
Jessica Pérez-Sancho et al.
Membrane contact sites (MCSs) are fundamental for intracellular communication, but their role in intercellular communication remains unexplored. We show that in plants, plasmodesmata communication bridges function as atypical endoplasmic re...
Victoria N Parikh,Sharlene M Day,Neal K Lakdawala et al.
Victoria N Parikh et al.
Cardiomyopathies are primary disorders of the heart muscle. Three key phenotypes have been defined, based on morphology and arrhythmia burden: hypertrophic cardiomyopathy (HCM), with thickened heart muscle and diastolic dysfunction; dilated...
Jacqueline Cordes,Shubo Zhao,Carla M Engel et al.
Jacqueline Cordes et al.
RNA plays a central role in protein biosynthesis and performs diverse regulatory and catalytic functions, making it essential for all processes of life. Like DNA, RNA is constantly subjected to damage from endogenous and environmental sourc...
Artem Khan,Yuyang Liu,Mark Gad et al.
Artem Khan et al.
Solute carrier (SLC) proteins play critical roles in maintaining cellular and organismal homeostasis by transporting small molecules and ions. Despite a growing body of research over the past decade, physiological substrates and functions o...