The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [0.03%]
免疫蛋白酶体扰乱神经元代谢并驱动多发性硬化症的神经退行性病变
Marcel S Woo,Johannes Brand,Lukas C Bal et al.
Marcel S Woo et al.
Inflammation, aberrant proteostasis, and energy depletion are hallmarks of neurodegenerative diseases such as multiple sclerosis (MS). However, the interplay between inflammation, proteasomal dysfunction in neurons, and its consequences for...
Interfamily co-transfer of sensor and helper NLRs extends immune receptor functionality between angiosperms [0.03%]
高等植物中传感器和辅助NLR受体的组间转移扩展了免疫受体的功能性
Xiaofei Du,Maheen Alam,Kamil Witek et al.
Xiaofei Du et al.
Plant nucleotide-binding, leucine-rich repeat (NLR) immune receptors recognize pathogen effectors and activate defense. NLR genes can be non-functional in distantly related plants (restricted taxonomic functionality, RTF). Here, we enable S...
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging [0.03%]
通过成像进行单细胞转录组分析和多模态谱型(STAMP)
Emanuele Pitino,Anna Pascual-Reguant,Felipe Segato-Dezem et al.
Emanuele Pitino et al.
Single-cell RNA sequencing has revolutionized our understanding of cellular diversity but remains constrained by scalability, high costs, and the destruction of cells during analysis. To overcome these challenges, we developed STAMP (single...
Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians [0.03%]
马来半岛原住民的头癣菌（Trichophyton concentricum）感染及皮肤微生物群
Yi Xian Er,Soo Ching Lee,Chioma Aneke et al.
Yi Xian Er et al.
Recent outbreaks of multidrug-resistant fungi infecting human skin emphasize the importance of understanding fungal pathophysiology and spread. In efforts to address health concerns with various Indigenous Peninsular Malaysians (Orang Asli ...
Rebecka J Sepela,Hao Jiang,Yern-Hyerk Shin et al.
Rebecka J Sepela et al.
Microbial communities coat nearly every surface in the environment and have co-existed with animals throughout evolution. Whether animals exploit omnipresent microbial cues to navigate their surroundings is not well understood. Octopuses us...
Joel Vizueta,Zijun Xiong,Guo Ding et al.
Joel Vizueta et al.
Ants originated over 150 million years ago through an irreversible transition to superorganismal colony life. Comparative analyses of 163 ant genomes, including newly generated whole-genome sequences of 145 ant species, reveal extensive gen...
Tamir Eliav,Shir R Maimon,Ayelet Sarel et al.
Tamir Eliav et al.
The hippocampus is crucial for memory. Memory consolidation is thought to be subserved by hippocampal "replays" of previously experienced trajectories. However, it is unknown how the brain replays long spatial trajectories in very large, na...
A percolation phase transition controls complement protein coating of surfaces [0.03%]
渗流相变控制补体蛋白的表面附着现象
Zhicheng Wang,Sahil Kulkarni,Jia Nong et al.
Zhicheng Wang et al.
When a material enters the body, it is immediately attacked by hundreds of proteins, organized into complex networks of binding interactions and reactions. How do such complex systems interact with a material, "deciding" whether to attack? ...
Senescence-resistant human mesenchymal progenitor cells counter aging in primates [0.03%]
一种抗衰老的人体间充质干细胞能对抗灵长类动物的衰老
Jinghui Lei,Zijuan Xin,Ning Liu et al.
Jinghui Lei et al.
Aging is characterized by a deterioration of stem cell function, but the feasibility of replenishing these cells to counteract aging remains poorly defined. Our study addresses this gap by developing senescence (seno)-resistant human mesenc...
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue [0.03%]
Perturb-多模态：在完整哺乳动物组织中进行成像和测序的汇集遗传筛选平台
Reuben A Saunders,William E Allen,Xingjie Pan et al.
Reuben A Saunders et al.
Metazoan life requires the coordinated activities of thousands of genes in spatially organized cell types. Understanding the basis of tissue function requires approaches to dissect the genetic control of diverse cellular and tissue phenotyp...