SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis [0.03%]
SLC25A45是线粒体从头合成左旋肉碱及蛋氨酸和苏氨酸甲基吸收所必需的基因
Marilia M Dias,Martin S King,Engy Shokry et al.
Marilia M Dias et al.
Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbed methylated amino acid homeostasis is associated with cardiovascular disease and renal fa...
Engineered hypercompact Fanzor-ωRNA system with enhanced genome editing activity [0.03%]
一种工程化紧凑型Fanzor-ωRNA系统，具有增强的基因组编辑活性
Guoli Zhao,Yuling Liu,Ganggang Zhang et al.
Guoli Zhao et al.
As programmable RNA-guided DNA nucleases found in eukaryotes, Fanzors have shown promise in genome editing with their compact size. A wide variety of RuvC-containing Fanzor nucleases have been identified in various eukaryotes and their viru...
Florian Roisné-Hamelin,Hon Wing Liu,Nils Maréchal et al.
Florian Roisné-Hamelin et al.
Structural maintenance of chromosome (SMC) complexes perform critical functions by folding DNA through loop extrusion. The choreography and outcome of SMC DNA loading prior to loop extrusion, however, remain elusive. Here, we use cryo-elect...
Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs [0.03%]
脂质调控的T细胞受体酪氨酸基序磷酸化层级结构
Hua Li,Li Meng,Chun Chu et al.
Hua Li et al.
As the antigen receptor, the T cell receptor (TCR)-CD3 complex contains a panel of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 subunits to transduce diverse antigen signals, but the mechanism underlying TCR signaling ...
A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context [0.03%]
P体和Whi3凝集物网络根据细胞背景调整细胞命运决定
Thomas R Peskett,Ana-Maria Farcas,Sung Sik Lee et al.
Thomas R Peskett et al.
Cells use information about their environments and internal states to decide whether to proliferate, differentiate, or enter non-proliferative states such as quiescence and senescence. But how do they integrate this information to make unam...
Alexandra Indeglia,Andrea Valdespino,Giulia Pantella et al.
Alexandra Indeglia et al.
TP53 encodes for the transcription factor p53, which binds to a diverse set of target genes in response to stress. Activation of p53 results in highly specific transcriptional responses, but the regulation of promoter selectivity by p53 is ...
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed [0.03%]
PARP1自修饰促进忠实的Okazaki片段处理并限制复制叉速度
Jonas D Elsborg,Sebastian H N Munk,Alba Adelantado-Rubio et al.
Jonas D Elsborg et al.
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying i...
Michael-Christopher Keogh,Genevieve Almouzni,Andrew J Andrews et al.
Michael-Christopher Keogh et al.
Histone post-translational modifications (PTMs) are crucial to eukaryotic genome regulation, with a range of reported functions and mechanisms of action. Though often studied individually, it has long been recognized that the modifications ...
Yury S Bykov
Yury S Bykov
In two recent papers in Cell, Zhu et al.1 and Luo et al.2 use selective ribosome profiling to identify the substrates and timing of co-translational protein targeting to mitochondria. The results suggest a mechanism that is very different f...
Spheres, worms, and packing problems in the nanoscale assembly of ALS-linked protein Matrin-3 [0.03%]
球形、线形和与ALS相关的Matrin-3蛋白纳米尺度装配中的填充问题
Ashok A Deniz
Ashok A Deniz
Matrin-3 (MATR3) is an RNA-binding protein that forms higher-order assemblies and pathological inclusions associated with neurodegenerative diseases. In this issue of Molecular Cell, Sprunger et al.1 explore the assembly of MATR3 and find t...