x-Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca2+-Stabilized Expanded Active-Site Cleft Adapted for Phospholipid Binding [0.03%]
放线霉磷脂酶D的X-射线晶体结构显示一个Ca2+固化的扩大的活性部位裂隙适合于磷脂结合
Yoshiaki Yasutake,Tatsuya Hirata,Shunsuke Nomura et al.
Yoshiaki Yasutake et al.
Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to generate phosphatidic acid and free head groups such as choline. Among bacterial PLD enzymes, Streptomyces chromofuscus PLD (SchPLD), a member of the alkaline phosphatase D ...
The Mycobacterium tuberculosis Rv0132c Gene Product Mtb-FGD2 Can Act as an F420-Dependent Glucose Dehydrogenase [0.03%]
结核分枝杆菌Rv0132c基因产物Mtb-FGD2可作为F420依赖型葡萄糖脱氢酶
Adewale V Aderemi,Matthew Snee,Richard B Tunnicliffe et al.
Adewale V Aderemi et al.
The role of the cell envelope-associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it fu...
Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation [0.03%]
丝氨酸273磷酸化与赖氨酸268和293乙酰化在PPARγ中的相互作用及其对PPARγ激活的影响
Caique Camargo Malospirito,Marieli Mariano Gonçalves Dias,Gabriel Ernesto Jaha et al.
Caique Camargo Malospirito et al.
Post-translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphoryla...
Aoi Fukushima,Arina Ouma,Hiroki Teruse et al.
Aoi Fukushima et al.
G protein-coupled receptors (GPCRs) can form oligomers, which activate distinct signaling pathways compared to monomeric GPCRs. Oligomerization influences GPCR trafficking, ligand affinity, and signal transduction, and has been implicated i...
Genomic, Proteomic, and Structural Insights Into the Transition of FtsZ From Thermophiles to Mesophiles Across the Prokaryotic Kingdom [0.03%]
从整个原核界中嗜热菌到嗜中温菌的细胞分裂蛋白FtsZ的转变：基因组、蛋白质和结构洞察
Dipanjan Ghosh,Prithvi Basak,Sukhendu Mandal et al.
Dipanjan Ghosh et al.
Understanding how cellular macromolecules adapt in thermophilic and mesophilic organisms across different thermal environments provides important insights into evolutionary mechanisms. These mechanisms enable early life forms to maintain es...
In Silico Structure-Guided Design of Peptide Candidates Targeting γ-Secretase Subunit Assembly [0.03%]
Selcen Arı Yuka,Kübra Telli,Alper Yılmaz
Selcen Arı Yuka
The γ-secretase complex is a membrane-embedded protease essential for intramembrane cleavage of substrates such as Notch receptors and the amyloid precursor protein (APP), processes central to cancer progression and Alzheimer's disease (AD...
Fulvio Floriani,Carla Borri Voltattorni,Riccardo Montioli
Fulvio Floriani
Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal-5'-phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ-amino group of L-ornithine (L-Orn) to α-ketoglutarate (α-KG) yielding glutamate-5-semia...
Review
Proteins. 2026 Mar 26. DOI:10.1002/prot.70134 2026
Computational Discovery of MERS-CoV Main Protease Inhibitors Through Screening and Molecular Dynamics Simulations [0.03%]
基于虚拟筛选及分子动力学模拟的MERS-CoV 主蛋白酶抑制剂的发现与优化研究
Shahidul M Islam,Md Saidur Rahman,Sidhant Singla et al.
Shahidul M Islam et al.
Targeting the main protease (Mpro) of coronaviruses has emerged as a promising therapeutic strategy for combating viral infections. Despite the global health threat posed by Middle East Respiratory Syndrome Coronavirus (MERS-CoV), no vaccin...
The X-Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two-Component Flavin-Dependent Tryptophan Halogenase [0.03%]
菠萝蛋白酶类似物硼化合物F的X射线晶体结构
Zheng Ma,Emily W Rady,Aravinda J de Silva et al.
Zheng Ma et al.
BorF is a short-chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan-6-halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X-ray c...
HAGGNN: Hydration-Aware Geometric Graph Neural Network for Protein Thermal Stability Prediction [0.03%]
利用Hydration-Aware几何图神经网络预测蛋白质热稳定性
Yingying Jiang,Lingzhi Liu,Yanrui Ding
Yingying Jiang
Water plays a fundamental thermodynamic role in determining protein structure, function, and stability. Rather than merely acting as a passive solvent, water actively participates in entropy-driven free energy changes, which are crucial for...