Lee-Shin Chu,Sudeep Sarma,Da Xu et al.
Lee-Shin Chu et al.
Recent diffusion-based approaches to protein-protein docking typically decouple structure generation from decoy ranking. We introduce DFMDock (Denoising Force Matching for Docking), a unified diffusion model that integrates generative sampl...
Structural and Functional Roles of Arg85-Mediated Inter-Motif Interactions in Human dUTPase [0.03%]
人源dUTP酶中精氨酸85介导的跨 motif 互作的结构与功能作用研究
Moeka Nakashima,Honoka Teruya,Yuuna Horinouchi et al.
Moeka Nakashima et al.
Human dUTPase prevents uracil incorporation into DNA by hydrolyzing dUTP to dUMP, thereby maintaining genome integrity. Its catalytic activity is mediated by five conserved motifs (I-V) that cooperatively form the active site. Arg85, a high...
Structural and Biochemical Characterization of the Diaminopimelate Epimerase DapF From Pseudomonas aeruginosa PA14 [0.03%]
铜绿假单胞菌PA14二氨基庚二酸差向异构酶DapF的结构与生化研究
Philipp Schneider,Claudia Hanko,Konrad Büssow et al.
Philipp Schneider et al.
The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug-resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potentia...
Structural and Stability Analysis of de Novo Designed Proteins Incorporating a Plant Self-Incompatibility Motif [0.03%]
从头设计包含植物自不亲和性模体的蛋白质的结构与稳定性分析
Hakuto Miyoshi,Koya Sakuma,Yoshitaka Moriwaki et al.
Hakuto Miyoshi et al.
Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering s...
BET Bromodomain Targeting by NSAIDs: Structural, Biophysical, and Computational Insights [0.03%]
非甾体抗炎药靶向溴结构域的机制：结构、生物物理及计算研究新进展
Ashok Sridhar,Nivetha Kandhasami,Shruti Mathur et al.
Ashok Sridhar et al.
The bromodomain and extra-terminal (BET) family of proteins, which regulate chromatin function, is an established potential drug target for treating major diseases such as cancer and inflammatory conditions. There is significant research fo...
Luca Palazzolo,Simona Daniele,Davide Bianchi et al.
Luca Palazzolo et al.
Sodium is an allosteric modulator of several class-A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR1...
Differences in the Activities of Domain-Swapped Chimeras of Two Homologous GH57 Glucanotransferases Suggest That a Glucan-Binding DUF Could Influence Donor Substrate Specificity [0.03%]
两个同源GH57型糖基转移酶的结构域置换嵌合体活性差异表明，一种糖结合型DUF可能会影响供体底物特异性
Arpita Sarkar,Pallavi Kaila,Purnananda Guptasarma
Arpita Sarkar
Eight enzymes of the GH57 family of dis-proportionating 4-α-glucanotransferases have been structurally characterized till date, including five of archaeal hyperthermophilic origin, and three of bacterial origin. Our focus here lies upon th...
An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses [0.03%]
拟南芥tRNA剪接内切酶复合物的(αβ)2型结构模型及其进化分析
Mohammad Moniruzzaman,Markus Englert,Kazuhito Akama
Mohammad Moniruzzaman
The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre-tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular f...
BioMatics 1.0: A Wasserstein Distance Approach for Next-Generation Multiple Sequence Alignment [0.03%]
BioMatics 1.0：下一代多重序列比对的瓦瑟斯特距离方法
Orkid Coskuner-Weber,Yusuf Emre Ari,Yildiray Efe Berberoglu et al.
Orkid Coskuner-Weber et al.
Accurate multiple sequence alignment (MSA) is central to understanding protein evolution, structure, and function. We present BioMatics 1.0, a novel MSA algorithm that applies optimal transport principles through the Wasserstein first-order...
Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis [0.03%]
一种新的抗侵袭性念珠菌病疫苗候选药物：工程化的HSP90-MP65二价融合抗原
Leszek Wawiórka
Leszek Wawiórka
Invasive candidiasis represents a critical global health challenge, causing approximately 6.5 million bloodstream infections annually with mortality rates exceeding 60%. The emergence of multidrug-resistant Candida strains necessitates nove...