Molecular alterations in high-grade neuroendocrine tumors of the small intestine [0.03%]
高度恶性的小肠神经内分泌肿瘤的分子改变
Agathe Hercent,Julien Masliah-Planchon,David Cohen et al.
Agathe Hercent et al.
High-grade neuroendocrine tumors of the small intestine are separated into two groups: well-differentiated neuroendocrine tumors (NETs, high-grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entitie...
Spatial analysis of HPV-associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression [0.03%]
空间分析表明与宫颈癌进展相关的HPV相关宫颈上皮内瘤样组织具有不同的免疫特征
Gianna Pavilion,Hani Vu,Zherui Xiong et al.
Gianna Pavilion et al.
Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV-related cancers continue to rise. For the development of effective prevention strategies in high-risk patients, we aimed to better ...
Genome-wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas [0.03%]
B1和B2型胸腺瘤的全基因组非编码突变模式及线粒体异质性分析
Kohei Fujikura,Isabel Correa,Susanne Heck et al.
Kohei Fujikura et al.
Type B1 and B2 thymomas are lymphocyte-rich malignant tumours with few somatic mutations in protein-coding regions of the nuclear genome; nonetheless, noncoding regions remain uncharacterized. Here, we developed a method to isolate pure thy...
Small cell neuroendocrine carcinoma of the cervix: diagnostic challenges and emerging molecular insights† [0.03%]
宫颈小细胞神经内分泌癌的诊断挑战及分子新见解
Alphonse Charbel,Gaëlle Akiki,Sarah-Slim Diwan et al.
Alphonse Charbel et al.
Small cell neuroendocrine carcinoma of the cervix (SCNECC) is a rare and highly aggressive malignancy with poor prognosis that predominantly affects premenopausal women. Histopathological evaluation is central to diagnosis and clinical mana...
Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia [0.03%]
雌激素调节影响前列腺疾病 或可解释男性前列腺增生的种族差异性
Teresa T Liu,Laura E Pascal,Emily A Ricke et al.
Teresa T Liu et al.
Lower urinary tract symptoms (LUTS), associated with benign prostatic hyperplasia (BPH), are an aging-related disease, with more than 210 million cases worldwide. Estrogen exposure and estrogen regulation have been implicated in a variety o...
Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy [0.03%]
高ABCC2乳头状肾细胞癌显示免疫逃避型特征与良好的免疫治疗反应相关
Vincent Francis Castillo,Abraam Zakhary,Fabio Rotondo et al.
Vincent Francis Castillo et al.
The use of immune checkpoint inhibitors is a promising therapeutic strategy for metastatic papillary renal cell carcinoma (PRCC); however, predictive biomarkers remain limited. PRCCs with high ABCC2 expression represent an aggressive subset...
Novel growth pattern-specific digital marker of TILs improves stratification of lung adenocarcinoma patients [0.03%]
新颖的肿瘤浸润淋巴细胞生长模式特异性数字标记物可改善肺腺癌患者的分层治疗效果
Arwa AlRubaian,Ayesha Azam,Nasir M Rajpoot et al.
Arwa AlRubaian et al.
Lung adenocarcinoma (LUAD) is one of the most prevalent forms of cancer and continues to be associated with high mortality rates, despite recent advances in cancer therapy. Effective risk stratification is critical for guiding treatment dec...
Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation [0.03%]
乳腺癌易感基因+2T变异体非典要捐赠剪接位点的生成及其对临床解释的影响
Inés Llinares-Burguet,Lara Sanoguera-Miralles,Elena Bueno-Martínez et al.
Inés Llinares-Burguet et al.
Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5' splice sites (5'ss) are generally strong indicators of...