Utility of pancreatic tumor scrapings for organoid development and precision medicine strategies [0.03%]
胰腺肿瘤刮片用于类器官培养及精准医疗的初步探索研究
Caitlin F Tsang,Hardik Patel,Fatim M Kouassi et al.
Caitlin F Tsang et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to late diagnosis and chemoresistance. Patient-derived organoids (PDOs) hold promise for predicting individualized drug responses, but their establishment is often ...
Hierarchical image pyramid transformer framework for automated breast cancer molecular subtyping using tissue microarrays [0.03%]
基于组织微阵列的乳腺癌分子亚型自动分类的层次图像金字塔变换器框架
Baizhou Li,Yuting Zhong,Zehang Xing et al.
Baizhou Li et al.
The heterogeneity of breast cancer at molecular and histological levels poses significant challenges for precise diagnosis and treatment. Current molecular subtyping, crucial for guiding personalized therapy, relies on immunohistochemistry,...
Integrating artificial intelligence (AI) into colorectal cancer reporting [0.03%]
人工智能(AI)在结直肠癌影像报告中的应用集成
Konstantin Bräutigam,Ann-Marie Baker,Viktor H Koelzer et al.
Konstantin Bräutigam et al.
Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortal...
Cancer-associated fibroblast subtypes in the tumor microenvironment of prostate cancer and associations to patient outcomes [0.03%]
肿瘤相关成纤维细胞亚型与前列腺癌患者的临床结局之间的关系研究
Marcus Lunau Blanke,Paul Vinu Salachan,Jeanette Bæhr Georgsen et al.
Marcus Lunau Blanke et al.
Prostate cancer (PC) is a prevalent malignancy, and outcomes range from indolent disease to terminal illness. Prostate-specific antigen-based diagnostics lack specificity and correlation with tumor aggressiveness, leading to overdiagnosis a...
Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease [0.03%]
破解转化生长因子β1信号通路与邓⽒⽒挛缩胶原蛋⽩白合成之间的关联
Gabriella Cooper,Jade A Gumbs,Sahem Alkharabsheh et al.
Gabriella Cooper et al.
Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to conti...
Single-nucleus RNA sequencing identifies a novel tenogenic heterologous differentiation in endometrial carcinosarcomas: implications for diagnosis and tumor classification [0.03%]
单核RNA测序揭示了子宫肉瘤中一种新的肌腱样异质性分化：对诊断和肿瘤分类的意义
Silvia González-Martínez,José Palacios,Irene Carretero-Barrio et al.
Silvia González-Martínez et al.
Carcinosarcomas (CSs) are aggressive biphasic tumors characterized by epithelial and mesenchymal components, whose histogenesis and differentiation dynamics remain poorly understood. We present single-nucleus RNA sequencing (snRNA-seq) anal...
Mining bulk transcriptomic datasets identifies inflammasome activation and antigen presentation as key novel mechanisms of BK polyomavirus-associated nephropathy [0.03%]
挖掘大规模转录组数据集识别出炎症小体激活和抗原呈递是BK多瘤病毒相关肾病的关键新机制
Lachlan A Davidson,Natalie M Niessen,Matthew Rowlandson et al.
Lachlan A Davidson et al.
BK polyomavirus (BKPyV) is a viral infection experienced by kidney transplant recipients that can lead to the development of BKPyV-associated nephropathy (BKPyVAN), graft dysfunction, and loss. There are no BKPyV-specific treatments availab...
Relative MYC downregulation and RUNX2 upregulation orchestrate partial epithelial-mesenchymal transition in colorectal cancer tumor budding and poorly differentiated clusters [0.03%]
MYC下调和RUNX2上调在结直肠癌肿瘤芽和分化不良簇的部分上皮间质转化中的协同作用
Tsuyuha Koba,Takashi Hibiya,Takahiro Shibayama et al.
Tsuyuha Koba et al.
Tumor budding and poorly differentiated clusters are key prognostic indicators in colorectal cancer, yet the molecular mechanisms underlying their formation remain incompletely characterized. Using the GeoMx Digital Spatial Profiler, we ana...
Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing [0.03%]
内藤顿综合征的蛋白酶级联失调：从分子病理学到临床前药物试验
Eleni Zingkou,Evangelos Bisyris,Georgios Pampalakis et al.
Eleni Zingkou et al.
Netherton syndrome (NS) is a rare, severe, and often life-threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a hi...
Uncovering the potential of pathomics: prognostic prediction and mechanistic investigation of pancreatic cancer [0.03%]
揭示路径组学的潜力：胰腺癌预后预测和机制研究
Long Liu,Xiaohong Zhao,Fabiao Zhang et al.
Long Liu et al.
A machine learning-based pathomics model was investigated for its value and biological significance in predicting overall survival (OS) after surgery in pancreatic cancer patients. Data from 173 patients with pancreatic ductal adenocarcinom...