Optical genome mapping enhanced by refined variant interpretation in pediatric acute lymphoblastic leukemia [0.03%]
改良后的变异解释增强的光学基因组测绘在儿童急性淋巴细胞白血病中的应用
Anna Bekő,Borbála Péterffy,Alex Hughes et al.
Anna Bekő et al.
Reliable detection of structural variants (SVs) and copy number variations (CNVs) is crucial in the contemporary diagnostics of pediatric B-cell acute lymphoblastic leukemia (B-ALL). However, limitations of commonly used conventional and mo...
EBV status prediction in gastric carcinoma biopsy images using multiple bag instance learning and foundation model in multicenter data [0.03%]
基于多包实例学习和基础模型的胃癌活检图像EBV状态预测方法研究
Haeyoun Kang,Yujin Nam,Dat Ngo et al.
Haeyoun Kang et al.
Epstein-Barr virus associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype of gastric cancer with prognostic and therapeutic significance. Current diagnostic practice relies on Epstein-Barr virus-encoded small RNA (EBE...
TIM3 as a therapeutic target in anaplastic thyroid cancer: upregulation in M2-like macrophages induced by tumor microenvironment-derived TGFβ1 [0.03%]
TIM3作为分化型甲状腺癌治疗靶点：肿瘤微环境来源的TGFβ1诱导巨噬细胞向M2极化上调TIM3表达
Agustina Jaroszewski,Yeon-Sook Choi,Florencia Hellriegel et al.
Agustina Jaroszewski et al.
Thyroid cancer (TC) is the most common endocrine malignancy. While papillary thyroid cancer (PTC) generally has a favorable prognosis, anaplastic thyroid cancer (ATC) is rare but highly aggressive, with limited treatment options, highlighti...
Diversified cell origin of Helicobacter pylori eradication-responsive gastric diffuse large B-cell lymphomas [0.03%]
幽门螺旋杆菌根除治疗反应型胃弥漫大B细胞淋巴瘤的多样化细胞起源
Sung-Hsin Kuo,Kun-Huei Yeh,Chung-Wu Lin et al.
Sung-Hsin Kuo et al.
A significant proportion of gastric diffuse large B-cell lymphoma with mucosa-associated lymphoid tissue [DLBCL(MALT)] and without MALT ('pure' DLBCL) can be resolved by Helicobacter pylori eradication (HPE). Gastric MALT lymphoma is an ind...
Vancomycin enriches Parabacteroides goldsteinii in the gut and promotes reconstruction of the hepatobiliary system in cholestasis [0.03%]
万古霉素通过增加胆汁淤积小鼠肠道中Parabacteroides goldsteinii的富集从而促进肝胆系统的重建
Shu-Hao Hsu,Huey-Huey Chua,Bang-Yu Liou et al.
Shu-Hao Hsu et al.
Impaired bile secretion disrupts the gut microbiome and perpetuates cholestatic liver injury. Vancomycin (VCM) has been shown to improve cholestasis in human patients, but its biological effects remain unclear. This study aimed to investiga...
Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ [0.03%]
子宫内膜癌去分化与人类白细胞抗原I类分子沉默相关，并可通过干扰素-γ恢复
Antonio De Leo,Madison Wickenberg,Marco Grillini et al.
Antonio De Leo et al.
Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low-grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non-Fermentab...
Exosomal lncRNA PVT1 promotes fibroblast activation and colon cancer progression via miR-23b-5p signaling [0.03%]
外泌体长链非编码RNA PVT1通过miR-23b-5p信号促进成纤维细胞活化和结肠癌进展
Liuping You,Zhiqiang Liu,Boyu Zhang et al.
Liuping You et al.
Colon cancer progression is closely associated with the tumor microenvironment, where cancer-associated fibroblasts (CAFs) play a pivotal role. Exosomal long non-coding RNAs (lncRNAs) are known to modulate the tumor stroma, but the role of ...
Practical considerations for pathologists when selecting digital pathology systems: an ESDIP guide [0.03%]
数字化病理系统的选择指南：实践性考虑因素指导
Diana Montezuma,Vincenzo L&#x;Imperio,David Ameisen et al.
Diana Montezuma et al.
The implementation of digital pathology (DP) has been reported across academic, public, and private laboratory settings, providing valuable insights into workflow transformation. However, comparatively little guidance exists on how DP syste...
Functional validation of driver mutation-specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity [0.03%]
眼黑色素瘤驱动基因特异性生物标志物的功能验证：COL9A3在癌细胞可塑性中的作用
Qcc van den Bosch,R M Verdijk,H Fadlelseed et al.
Qcc van den Bosch et al.
Uveal melanoma (UM) is a deadly ocular malignancy with well-described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high-risk uveal melanoma progression remains relat...
Applying flow cytometry-based isolation of platelet-derived microparticles to banked human plasma for cellular studies [0.03%]
基于流式细胞仪的血小板衍生微颗粒制备及用于细胞研究的方法及其应用
Nima Fattahi,Tarun Tyagi,Fallyn Kirlin et al.
Nima Fattahi et al.
Platelet-derived microparticles (PMPs) constitute the majority of circulating microparticles in blood. PMPs carry cargo including RNA, protein, and miRNA, and play key pathophysiologic intercellular signaling roles in cardiovascular, autoim...