Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization
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Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water-holding functions and in initiating AD-like skin symptoms and disease-s... ...
