Primary thyroid B-cell lymphoma: molecular insights into its clonal evolution and relapse [0.03%]
原发性甲状腺B细胞淋巴瘤：其克隆进化和复发的分子见解
Maria-Myrsini Tzioni,Natsuko Watanabe,Zi Chen et al.
Maria-Myrsini Tzioni et al.
Primary thyroid lymphomas comprise largely extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) and diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma (FL). They commonly develop from a backgroun...
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis [0.03%]
深度学习在结直肠癌肿瘤纯度评估及对分子分析的影响研究
Lydia A Schoenpflug,Aikaterini Chatzipli,Korsuk Sirinukunwattana et al.
Lydia A Schoenpflug et al.
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either through visual pathological re...
Characterisation of GPR17-expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses [0.03%]
人脑梗死区GPR17阳性少突胶质前体细胞的表型及与反应性星形胶质增生的关系研究
Stefano Raffaele,Bettina Hjelm Clausen,Francesca Carolina Mannella et al.
Stefano Raffaele et al.
White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligod...
Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei [0.03%]
怪异核平滑肌瘤发展为子宫肉瘤的基因组和组织学特征分析
Christopher Felicelli,Xinyan Lu,Zachary Coty-Fattal et al.
Christopher Felicelli et al.
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN ...
Podocyte YAP ablation decreases podocyte adhesion and exacerbates FSGS progression through α3β1 integrin [0.03%]
podocyte YAP缺失通过α3β1整合素降低足细胞粘附并加重FSGS进展
Guangze Shao,Jitu Xu,Chencheng Hu et al.
Guangze Shao et al.
Severe proteinuria in focal segmental glomerulosclerosis (FSGS) is closely associated with decreased adhesion, and subsequent loss, of podocytes. Yes-associated protein (YAP) is a key transcriptional coactivator that plays a significant rol...
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens [0.03%]
用于活检和手术标本前列腺癌检测的深度学习模型的压力测试
Brennan T Flannery,Howard M Sandler,Priti Lal et al.
Brennan T Flannery et al.
The presence, location, and extent of prostate cancer is assessed by pathologists using H&E-stained tissue slides. Machine learning approaches can accomplish these tasks for both biopsies and radical prostatectomies. Deep learning approache...
CRISPR-Cas9 screening identifies the role of FER as a tumor suppressor [0.03%]
基于CRISPR-Cas9的筛选鉴定FER是肿瘤抑制因子
Jiaqi Wang,Ran Yang,Fengsheng Wang et al.
Jiaqi Wang et al.
It is important to systematically identify tumor suppressor genes (TSGs) to improve our understanding of tumorigenesis and develop strategies for early diagnosis and mitigating disease progression. In the present study, we used an in vivo g...
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis [0.03%]
人结肠类器官用于了解家族性腺瘤性息肉病发病机制的早期事件
Nolwenn Laborde,Alexandre Barusseaud,Muriel Quaranta et al.
Nolwenn Laborde et al.
Patients with familial adenomatous polyposis (FAP) harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. There is no validated treatment, and animal models are not sufficient to study FAP. Our aim was to inv...
Nicotinamide riboside targets mitochondrial unfolded protein response to reduce alcohol-induced damage in Kupffer cells [0.03%]
尼克酸核糖通过靶向线粒体未折叠蛋白反应减少库普弗细胞的酒精损伤
Jaeeun Lee,Hayoung Woo,Hyunju Kang et al.
Jaeeun Lee et al.
The pathogenesis of alcohol-related liver disease (ALD) is closely linked to mitochondrial dysfunction and impaired cellular energy metabolism. In this study, we explored how ethanol triggers inflammation, oxidative stress, and mitochondria...