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Podocyte YAP ablation decreases podocyte adhesion and exacerbates FSGS progression through α3β1 integrin

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Severe proteinuria in focal segmental glomerulosclerosis (FSGS) is closely associated with decreased adhesion, and subsequent loss, of podocytes. Yes-associated protein (YAP) is a key transcriptional coactivator that plays a significant role in maintaining cel... ...