Identification of actionable targets using DEPArray-based sorting of pure carcinoma and stromal populations from formalin-fixed paraffin-embedded tissues followed by shallow whole-genome sequencing [0.03%]
基于DEPArray的富集纯癌和间质细胞群体进行浅层全基因组测序以鉴定可操作靶点
Georgios Nteliopoulos,Evie Wren,Amelia Rushton et al.
Georgios Nteliopoulos et al.
Formalin-fixed paraffin-embedded (FFPE) tissue specimens represent precious resources for clinical genomic profiling studies, especially when coupled with comprehensive medical records. Even though next-generation sequencing (NGS) is an eff...
Issues and missed opportunities in lymph node assessment after neoadjuvant chemotherapy [0.03%]
新辅助化疗后淋巴结评估中的问题与缺失的机会
Lucy Ryan,Elena Provenzano,Anita Grigoriadis et al.
Lucy Ryan et al.
Assessment of axillary lymph nodes in breast cancer patients following neoadjuvant chemotherapy (NACT) is a crucial part of the clinical and pathological assessment of the disease and has prognostic and management implications. This, howeve...
Carmen Al Youssef,Mansour Alkobtawi,Rémi Safi et al.
Carmen Al Youssef et al.
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and is most often caused by cumulative UV exposure. However, cSCC may also arise independently of UV exposure, on sites of sustained skin damage like chronic ulc...
Fibroblast-specific palladin drives kidney fibrosis via MRTF-SRF signaling [0.03%]
成纤维细胞特异性Palladin通过MRTF-SRF信号促进肾纤维化
Naoki Yamamoto,Norihiko Sakai,Yuta Yamamura et al.
Naoki Yamamoto et al.
Fibrosis is a common end-stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin-related transcription factor (MRTF)-serum response factor (SRF) signaling drives the expression of fibrosis-related mol...
Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension [0.03%]
乳酸通过GPR81激活调控低氧条件下慢性髓性白血病细胞中BCR/Abl蛋白的表达
Giulio Menegazzi,Dayana Desideri,Alessio Biagioni et al.
Giulio Menegazzi et al.
Chronic myeloid leukemia (CML) is a stem cell-driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the ...
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts† [0.03%]
胰腺癌癌前病变的转化：简单黏液囊肿的作用
Paolo Riccardo Camisa,Daniele Campa,Irene Esposito et al.
Paolo Riccardo Camisa et al.
Pancreatic cystic lesions present a unique opportunity to identify and potentially prevent pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Until now, research has primarily focused on intraductal papillary mucino...
Super resolution of pathology images with hierarchical feature integration and local image patterns [0.03%]
基于层次特征整合和局部图像模式的病理图像超分辨率重建方法
Feng Xu,Lei Li,Shuyang Wang et al.
Feng Xu et al.
Recent advancements in pathological imaging have facilitated single-cell and subcellular-level analysis based on high-resolution images for tumor subtyping, cytomorphological assessment, and infection detection. As high-resolution imaging i...
DNA-hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53 mutation [0.03%]
无TP53基因突变的胃癌细胞通过过度甲基化DNA来抑制细胞凋亡
Yasunobu Mano,Keisuke Matsusaka,Motoaki Seki et al.
Yasunobu Mano et al.
p53 is one of the most important tumour suppressors exerting antitumour effects primarily via apoptosis. TP53 mutations are common in gastric tumorigenesis; however, nearly half of the gastric cancers (GCs) remain wildtype TP53 (TP53_WT). W...
Expression of SARS-CoV-2 entry-associated proteins in COPD airways: an immunohistochemical study [0.03%]
慢性阻塞性肺疾病气道中SARS-CoV-2入侵相关蛋白的表达：免疫组化研究
Larissa E Vlaming-van Eijk,Zarlasht Sarsam,Janna Bakker et al.
Larissa E Vlaming-van Eijk et al.
Coronavirus disease 2019 (COVID-19) is of special concern to patients with chronic obstructive pulmonary disease (COPD), given their susceptibility to exacerbations caused by respiratory tract infections. As the susceptibility of acquiring ...