Partial-EMT cell state correlates with single cell pattern of invasion in head and neck SCC keratinocytes [0.03%]
部分上皮间质转化状态与头颈部鳞癌角化细胞单细胞侵袭模式相关性研究
Pyung Hun Park,Lauren E Israel,Michael H Alexander et al.
Pyung Hun Park et al.
The presence of a single metastatic lesion significantly decreases overall survival in patients with head and neck squamous cell carcinoma (HNSCC), and invasion of malignant keratinocytes is one of the initial steps required for HNSCC metas...
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms† [0.03%]
胰腺管内乳头状黏液性肿瘤进展中肿瘤微环境调控的重要作用
Antonio Pea,Claudio Luchini
Antonio Pea
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have attracted substantial attention since they represent the most prevalent macroscopic precursor of pancreatic cancer. Most lesions show an epithelium with low-grade dysplas...
New insights into the genetic progression of cancer through longitudinal analysis of oral lesions [0.03%]
纵向分析口腔病变揭示癌症遗传演变的新见解
Leon J Wils,Jos B Poell,Arjen Brink et al.
Leon J Wils et al.
Genetic progression models of cancer continue to determine the roadmap of carcinogenesis, although the sequence of genetic events is inferred rather than empirically determined through longitudinal analyses. Here, we present a unique longit...
Maternal-foetal immune rejection: parallels between placental CHI and allograft rejection† [0.03%]
母胎免疫排斥：胎盘CHI与同种异体移植排斥的类比
Panicos Shangaris,María Teresa Martín Monreal
Panicos Shangaris
Chronic histiocytic intervillositis (CHI) is a rare placental inflammatory lesion increasingly viewed through maternal-foetal immune rejection. In this invited commentary, we discuss how a recent study bolsters the paradigm that CHI represe...
LncRNA GAS5 ameliorates intestinal barrier injury by targeting the miR-223-3p/FBXW7 axis and inactivating NF-κB signaling in vitro and in vivo [0.03%]
长链非编码RNA GAS5通过靶向miR-223-3p/FBXW7轴并使NF-κB失活来改善体内外肠屏障损伤
Zhen Wang,Jin Yuan,Xuemei Qin et al.
Zhen Wang et al.
Sepsis is a potentially lethal syndrome that leads to multiple organ dysfunction. LncRNA GAS5 is closely related to sepsis; however, its detailed functions and mechanism in sepsis-triggered intestinal barrier dysfunction are unclear. In thi...
Spatial transcriptomics identifies SPARC as a prognostic marker in interstitial lung diseases [0.03%]
空间转录组学鉴定出SPARC是间质性肺病的预后标志物
Takayuki Niitsu,Toshiaki Kataoka,Kiyoharu Fukushima et al.
Takayuki Niitsu et al.
Interstitial lung diseases (ILDs) encompass a diverse group of pulmonary disorders, with progressive fibrosis leading to poor prognosis. Here we aimed to identify key molecules involved in progressive fibrosis across various ILDs, using spa...
Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression [0.03%]
NPM1和FBL的高表达与前列腺癌的侵袭性和进展有关
Sarina Saffarian,Ziwei Cai,Jordan Lam et al.
Sarina Saffarian et al.
The nucleolus is a membrane-less body present in the nucleus of the cell. The nucleolus is mainly involved in ribosomal RNA (rRNA) transcription and ribosome biogenesis for protein translation. During cancer formation, nucleolar morphology ...
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME, CDC7 and Ki67 [0.03%]
CSPG4在黑色素瘤和痣中的增强诊断潜力与PRAME、CDC7和Ki67的比较研究
Elias At Koch,Christina Seidel,Ramona Erber et al.
Elias At Koch et al.
Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for melanoma immunotherapy, but its expression in benign melanocytic lesions and its diagnostic value remain unexplored. This study assessed CSPG4 expression in benign nevi (B...
BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede antitumor immune responses in lung squamous cell carcinoma [0.03%]
BIRC3缺陷通过阻断GOT2泛素化降解抑制肺鳞癌抗肿瘤免疫反应
Qiang Zhang,Hongxu Sheng,Dongnan Ping et al.
Qiang Zhang et al.
In lung squamous cell carcinoma (LUSC), the proportion of exhausted CD8+ T cells is considerably higher than in lung adenocarcinoma (LUAD). The exhaustion of CD8+ T cells is responsible for the failure of immunotherapies, as terminally exha...
Julien Calderaro,Helen Morement,Frédérique Penault-Llorca et al.
Julien Calderaro et al.
Artificial intelligence (AI) methods for digital pathology have tremendous potential to improve cancer diagnostics, biomarkers, and ultimately patient care. These AI methods, if marketed and sold, require authorisation or clearance as in vi...