Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand [0.03%]
泰国东北部肝内胆管癌的染色体不稳定性及基因组改变
Raksawan Deenonpoe,Molly A Guscott,Sasithorn Watcharadetwittaya et al.
Raksawan Deenonpoe et al.
Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverr...
Periostin-IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation [0.03%]
骨膜素-IHH正向环路通过增强肝纤维化和肿瘤细胞增殖促进肝癌发生发展
Bin Liu,Xuebin Li,Menghao Zhang et al.
Bin Liu et al.
The extracellular matrix protein periostin plays a critical role in the progression of hepatic fibrosis and hepatocellular carcinoma (HCC). However, little is known about how periostin regulates both hepatic fibrosis and tumor growth in the...
Investigating the mechanisms of indocyanine green tumour uptake in sarcoma cell lines and ex vivo human tissue [0.03%]
探究吲哚青绿在肉瘤细胞系和人体外组织中肿瘤摄取的机制
Corey David Chan,Marcus J Brookes,Toni A Pringle et al.
Corey David Chan et al.
Indocyanine green (ICG) is a well-established near-infrared dye which has been used clinically for several decades. Recently, it has been utilised for fluorescence-guided surgery in a range of solid cancer types, including sarcoma, with the...
Sparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer† [0.03%]
吸烟通过驱动三阴性乳腺癌干细胞样特性及上皮间质转化促进肿瘤恶性进展
Christopher Simpkins,Eneda Toska
Christopher Simpkins
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and HER2, and remains one of the most aggressive and therapeutically challenging breast cancer subtypes, marked by early relapse, m...
Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp [0.03%]
NLRP1和IL1B的遗传变异对妊娠期疟疾的影响：NLRP1在Plasmodium spp诱导的炎性小体活化中的作用不容忽视
Vinicius Nc Leal,Jessica A Ribeiro,Leticia Girardi Marra et al.
Vinicius Nc Leal et al.
We hypothesized that variants in inflammasome-related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria-endemic region in northern ...
Andrea Flesken-Nikitin,Matalin G Pirtz,Christopher S Ashe et al.
Andrea Flesken-Nikitin et al.
Serous endometrial carcinoma (SEC) is one of the most lethal types of uterine cancer, responsible for about 40% of all endometrial cancer-related deaths. Cell state dynamics during the early stages of SEC remain largely unknown, thereby hin...
High-fat diets influence breast cancer progression by modulating CAF-immune cell interactions through PLAT signaling [0.03%]
高脂饮食通过PLAT信号调节癌相关成纤维细胞-免疫细胞相互作用影响乳腺癌进展
Weihan Li,Jiangshan He,Jingjing Li et al.
Weihan Li et al.
Breast cancer progression is profoundly influenced by interactions within the tumor microenvironment, particularly between cancer-associated fibroblasts and immune cells. This study investigated how cancer-associated fibroblasts impact immu...
APC-related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation [0.03%]
与APC相关的多个唾液腺病变：空间转录组分析揭示了WNT激活的渐进式变化
Fiona Chan-Pak-Choon,Catherine Beaumont,José Camacho Valenzuela et al.
Fiona Chan-Pak-Choon et al.
Attenuated familial adenomatous polyposis (AFAP) is a disorder caused by germline pathogenic variants in APC and is characterized by the presence of
Overexpression of m7G writers METTL1 and BUD23 confers oncogenicity in kidney renal clear cell carcinoma [0.03%]
METTL1和BUD23的过度表达通过m7G修饰促肾细胞癌发生发展
Anni Su,Jessica Tieng,Xueying S Xu et al.
Anni Su et al.
Emerging evidence shows that N7-methylguanosine (m7G) modification and its writers contribute to the development of diverse cancers. However, the role of m7G writers in kidney renal clear cell carcinoma (KIRC) remains unclear. In this study...
Characteristic miRNA profiles represent clinicopathological diversity of small cell lung cancer [0.03%]
特征性微小核糖核酸谱系代表小细胞肺癌的临床病理差异性
Masafumi Horie,Hiroshi Takumida,Hayato Koba et al.
Masafumi Horie et al.
Small cell lung cancer (SCLC) is classified into distinct molecular subtypes based on the expression patterns of four transcription regulators: achaete-scute homolog 1 (ASCL1), neuronal differentiation 1 (NEUROD1), POU class 2 homeobox 3 (P...