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mTOR-mediated upregulation of B7-H3 in MiT/TFE translocation renal cell carcinoma

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Clinical trials targeting B7-H3 (CD276), a membranous immunomodulatory molecule in the B7 superfamily, have shown promise in prostate cancer and may be expanded to additional tumor types with high expression, such as those with mTOR signaling activation. MiT/T... ...