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Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ

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Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low-grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non-Fermentable (SWI/SNF) complex... ...