The therapeutic exploitation of IL-1 in cancer: Controlling tumor progression and resistance to targeted therapies [0.03%]
肿瘤治疗中IL-1的作用：控制肿瘤进展和对靶向疗法的耐药性
Valerio Gelfo,Federica Pagano,Alessandra Morselli et al.
Valerio Gelfo et al.
The interleukin-1 (IL-1) superfamily encompasses a group of cytokines with central roles in inflammation and immune regulation. IL-1 is directly implicated in activating survival and proliferative pathways in transformed cells, orchestratin...
Access to CAR-T therapy in Latin America: Barriers, gaps, and pathways forward [0.03%]
拉美地区CAR-T治疗的可及性：障碍、差距及未来之路
Jorge Contreras,Lauren Herschbein,Nimisha Mathur et al.
Jorge Contreras et al.
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies, offering durable responses in conditions such as diffuse large cell lymphoma, B-cell leukemias and multiple myeloma. However, access...
Chronic Chagas disease and type 2 diabetes comorbidity. The scenario in which two differently driven inflammatory mechanisms meet [0.03%]
慢性查加斯病与2型糖尿病的共病状况。两种不同驱动的炎症机制相遇的情景
Brenda Dinatale,Florencia Belén González,Oscar Adelmo Bottasso et al.
Brenda Dinatale et al.
Chagas disease (ChD) and Type 2 diabetes (T2D) originate from distinct etiological processes -infectious and metabolic, respectively- yet both share a chronic inflammatory and metabolic imbalance that profoundly impacts immune-endocrine hom...
Paulo Estevão,Ana Júlia Estumano Martins,Pedro M Moraes-Vieira
Paulo Estevão
Nutritional status and dietary composition profoundly influence immune responses, with carbohydrates, lipids, and proteins, acting as key regulators of immune cell metabolism, activation, and function. This review synthesizes current eviden...
Jiazhi Xu,Souleymane Abdoul-Azize,Lionel Apetoh
Jiazhi Xu
TH9 cells, a distinct subset of CD4+ T helper cells characterized by IL-9 production, have emerged as key players in cancer immunology. Initially recognized for their potent antitumor activity upon adoptive cell transfer against melanoma, r...
COVID-19 in Latin America: Clinical and immunological insights, vaccine development, and lessons for pandemic preparedness [0.03%]
拉丁美洲的新冠肺炎：临床和免疫学见解、疫苗研发及大流行准备工作的经验教训
Alejandro Torres-Flores,Eduardo Bautista-Sebastián,Tania Rivera-Hernández et al.
Alejandro Torres-Flores et al.
The COVID-19 pandemic had a profound impact on Latin America, exposing structural inequalities, fragmented healthcare systems, and longstanding technological dependence. The region experienced a high burden of infection and excess mortality...
Lorenz Kocheise,Mohamed-Reda Benmebarek,Mitchell Ho et al.
Lorenz Kocheise et al.
Adapting the success of chimeric antigen receptor T cell therapy from hematologic malignancies to solid tumors has become a major focus of ongoing research activities. However, the unique challenges posed by solid tumors, such as limited im...
Emerging roles of IL-9 and Th9 cells in respiratory viral illnesses [0.03%]
IL-9和Th9细胞在呼吸道病毒感染中作用的新角色
Jyotsna Dandotiya,Srikanth Sadhu,Rucha R Chandwaskar et al.
Jyotsna Dandotiya et al.
Upon antigenic stimulation and cytokine cues, CD4⁺ T cells differentiate into specialized helper subsets, giving rise to Th1, Th2, Th9 and Th17 cell lineages. These subsets orchestrate distinct immune functions that protect the host but ca...
Simone Mader,Markus Reindl
Simone Mader
Therapeutic immune tolerance for central nervous system autoimmune diseases - Prospects, challenges and pitfalls [0.03%]
中枢神经系统自身免疫病的治疗性免疫耐受-前景、挑战和陷阱
Andreas Lutterotti,Roland Martin
Andreas Lutterotti
Autoimmune diseases of the central nervous system (CNS), including multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), are characterized by c...