Diverse IL-9-secreting T helper cells direct responses in the allergic lung [0.03%]
多种分泌IL-9的T辅助细胞指导过敏性肺部的反应
Kaitlyn G Jackson,Mark H Kaplan
Kaitlyn G Jackson
IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease...
Markus F Neurath
Markus F Neurath
The involvement of T helper cells in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, has been a subject of considerable research interest. The clinical picture of IBD is characterised...
Targeting immune heterogeneity in liver metastases through in vivo genetic engineering [0.03%]
通过体内基因工程针对肝转移瘤的免疫异质性
Giovanna Giacca,Mario Leonardo Squadrito
Giovanna Giacca
The liver is both a central metabolic organ and a uniquely tolerogenic immune niche, which makes it a frequent site of liver metastases (LMS) and a challenging environment for immunotherapy. It is increasingly appreciated that resident live...
Jahanara Rajwani,Douglas J Mahoney
Jahanara Rajwani
Oncolytic viruses (OV) are designed to seek out and kill cancer cells, while simultaneously inciting potent antitumour immunity. While their exact mechanism of action is incompletely understood, therapeutic activity is proposed to rely on v...
IL-1 family members as regulators of lymphoid type-2 immunity in cancer [0.03%]
细胞因子IL-1家族调节淋巴样组织驻留T细胞在肿瘤中的功能
Stefania Roma,Filippo Colombo,Lucia De Monte et al.
Stefania Roma et al.
IL-1 family members, such as IL-1 and IL-33, are present in the tumor microenvironment and exert tumor-intrinsic and tumor-extrinsic functions with both pro- and anti-tumor effects. Among their immunoregulatory roles, both cytokines contrib...
HBV antigen as a tumour antigen in adoptive TCR-T cell therapy for HBV-related HCC: rationale and clinical effectiveness [0.03%]
乙型肝炎病毒表面抗原作为适应性T细胞受体-T细胞治疗乙肝相关肝癌的肿瘤抗原：理论依据及临床疗效评估
Shan He,Anthony T Tan,Antonio Bertoletti
Shan He
Hepatocellular carcinoma developing in patients with HBV chronic infection are marked by expression of whole or partial HBV antigens through a highly tissue-specific process, determined by the hepatotropism of HBV. HBV antigens are therefor...
TH9 cells and interleukin-9 in parasitic infections: Updates, opportunities, and challenges [0.03%]
TH9细胞和白细胞介素-9在寄生虫感染中的作用：最新研究、机遇与挑战
Javier Orozco-Cordoba,Cleofas Marcial-Medina,Paula Licona-Limón
Javier Orozco-Cordoba
Over the past decades, Interleukin-9 (IL-9) and TH9 cells, have gained attention as important regulators of diverse responses throughout the promotion of activation and expansion of diverse cell subtypes. TH9 cells have been studied in seve...
Cédric Rébé,François Ghiringhelli
Cédric Rébé
IL-1β belongs to the IL-1 family and has the particularity to need to be cleaved by caspase-1 to be active. Once processed, IL-1β is secreted and binds to IL-1R1 on target cells, leading to the transcription of specific genes. Within a tu...
Maria Eugenia Davola,Olga Cormier,Karen Mossman
Maria Eugenia Davola
Oncolytic viruses are gaining traction as novel cancer immunotherapy tools given their ability to selectively target transformed cells. While direct tumor debulking was historically considered their primary mode of action, it is now appreci...
Three's company: The cooperative signals behind the differentiation of Th9 cells [0.03%]
三位一体：Th9细胞分化背后的协同信号作用机制研究
J Alejandra Rodriguez,Humayra Habib,Matthew R Olson
J Alejandra Rodriguez
T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal...