Lorenz Kocheise,Mohamed-Reda Benmebarek,Mitchell Ho et al.
Lorenz Kocheise et al.
Adapting the success of chimeric antigen receptor T cell therapy from hematologic malignancies to solid tumors has become a major focus of ongoing research activities. However, the unique challenges posed by solid tumors, such as limited im...
Emerging roles of IL-9 and Th9 cells in respiratory viral illnesses [0.03%]
IL-9和Th9细胞在呼吸道病毒感染中作用的新角色
Jyotsna Dandotiya,Srikanth Sadhu,Rucha R Chandwaskar et al.
Jyotsna Dandotiya et al.
Upon antigenic stimulation and cytokine cues, CD4⁺ T cells differentiate into specialized helper subsets, giving rise to Th1, Th2, Th9 and Th17 cell lineages. These subsets orchestrate distinct immune functions that protect the host but ca...
Simone Mader,Markus Reindl
Simone Mader
Therapeutic immune tolerance for central nervous system autoimmune diseases - Prospects, challenges and pitfalls [0.03%]
中枢神经系统自身免疫病的治疗性免疫耐受-前景、挑战和陷阱
Andreas Lutterotti,Roland Martin
Andreas Lutterotti
Autoimmune diseases of the central nervous system (CNS), including multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), are characterized by c...
Liubo Zhang,Wei Jing,Yunbo Li et al.
Liubo Zhang et al.
Recent studies have revealed that neurotransmitters, as a class of important signaling molecules, have functional roles that extend beyond the traditional nervous system and play critical regulatory functions in the tumor immune microenviro...
Diverse IL-9-secreting T helper cells direct responses in the allergic lung [0.03%]
多种分泌IL-9的T辅助细胞指导过敏性肺部的反应
Kaitlyn G Jackson,Mark H Kaplan
Kaitlyn G Jackson
IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease...
Markus F Neurath
Markus F Neurath
The involvement of T helper cells in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, has been a subject of considerable research interest. The clinical picture of IBD is characterised...
Targeting immune heterogeneity in liver metastases through in vivo genetic engineering [0.03%]
通过体内基因工程针对肝转移瘤的免疫异质性
Giovanna Giacca,Mario Leonardo Squadrito
Giovanna Giacca
The liver is both a central metabolic organ and a uniquely tolerogenic immune niche, which makes it a frequent site of liver metastases (LMS) and a challenging environment for immunotherapy. It is increasingly appreciated that resident live...
Jahanara Rajwani,Douglas J Mahoney
Jahanara Rajwani
Oncolytic viruses (OV) are designed to seek out and kill cancer cells, while simultaneously inciting potent antitumour immunity. While their exact mechanism of action is incompletely understood, therapeutic activity is proposed to rely on v...
IL-1 family members as regulators of lymphoid type-2 immunity in cancer [0.03%]
细胞因子IL-1家族调节淋巴样组织驻留T细胞在肿瘤中的功能
Stefania Roma,Filippo Colombo,Lucia De Monte et al.
Stefania Roma et al.
IL-1 family members, such as IL-1 and IL-33, are present in the tumor microenvironment and exert tumor-intrinsic and tumor-extrinsic functions with both pro- and anti-tumor effects. Among their immunoregulatory roles, both cytokines contrib...