Cecilia Garlanda,Eduardo Bonavita,Roberto Garuti et al.
Cecilia Garlanda et al.
Inflammation is a pathogenetic driver of several pathological conditions, including cancer. The tumor microenvironment, which includes cellular, molecular, and structural components, is an essential component of cancer, involved in tumor pr...
Cecilia Garlanda,Eduardo Bonavita,Roberto Garuti et al.
Cecilia Garlanda et al.
Inflammation is a pathogenetic driver of several pathological conditions, including cancer. The tumor microenvironment, which includes cellular, molecular, and structural components, is an essential component of cancer, involved in tumor pr...
IL-1-driven systemic inflammation in tumour progression and metastatic spread [0.03%]
肿瘤进展和转移中IL-1驱动的全身性炎症反应
Jacqueline Alford,Hannah Garner
Jacqueline Alford
Inflammation is a fundamental immune response that protects against injury and infection; however, when unresolved, it can contribute to disease pathogenesis. Chronic inflammation is a hallmark of cancer that promotes tumour initiation and ...
Ferroptosis at the intersection of metabolism and immunity in pancreatitis and pancreatic cancer [0.03%]
代谢与免疫在胰腺炎和胰腺癌中的铁死亡交集
Fangquan Chen,Xiutao Cai,Ruirui Liang et al.
Fangquan Chen et al.
Ferroptosis links cellular metabolism to immune regulation. Beyond its role as an iron-dependent form of regulated cell death, ferroptosis generates signals, including oxidized lipids, iron metabolites, and damage-associated molecular patte...
IL-1β signaling as a molecular arbiter of stem cell plasticity: orchestrating the niches of repair, fibrosis, and cancer [0.03%]
IL-1β信号作为调控干细胞可塑性的分子仲裁者：协调修复、纤维化和癌症的生态位
Sua Yu,Seo Hyeon Lee,Min Seo Choi et al.
Sua Yu et al.
Interleukin-1β (IL-1β) has long been characterized as a foundational mediator of innate immunity, yet this designation captures only a fraction of its biological significance. A growing body of evidence now positions IL-1β as a molecular...
Myeloid cells as sources and targets of IL-1 family cytokines in cancer [0.03%]
白细胞介素-1家族细胞因子在癌症中的髓系细胞来源和靶点
Silvia Carnevale,Irene Di Ceglie,Anna Pia Lasaracina et al.
Silvia Carnevale et al.
Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, me...
Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting? [0.03%]
白细胞介素-1介导的炎症记忆：保护性训练还是适应不良的肿瘤印迹？
Despoina Xanthopoulou,Maria Crespo,Lydia Kalafati
Despoina Xanthopoulou
Interleukin-1 (IL-1) exerts a pivotal role in the regulation of innate immune responses and inflammatory processes. Beyond its local effects at the site of inflammation, IL-1 acts as a systemic regulator of hematopoiesis by reprogramming he...
Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics [0.03%]
慢性压力在十字路口：解码炎症性肠病发病机制和治疗中的HPA-SAM-免疫-肠道轴
Ya-Fang Zhang,Yi-Yuan Li,Jin Jin
Ya-Fang Zhang
Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal ...
Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity [0.03%]
蛋白酪氨酸激酶在树突状细胞介导的抗肿瘤免疫中的作用
Misha Mao,Liwei Zhao,Guido Kroemer et al.
Misha Mao et al.
Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which i...
The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives [0.03%]
拉丁美洲和加勒比海地区的免疫系统：当地视角下的疾病与多样性研究展望
Ileana Licona-Limón,José Luis Maravillas-Montero,Maria Carolina Amezcua Vesely et al.
Ileana Licona-Limón et al.
Latin America and the Caribbean host one of the world's most complex intersections of ancestry, pathogen exposure, and environmental change, generating an immunological landscape that cannot be fully understood through frameworks derived fr...