Myeloid cells as sources and targets of IL-1 family cytokines in cancer [0.03%]
白细胞介素-1家族细胞因子在癌症中的髓系细胞来源和靶点
Silvia Carnevale,Irene Di Ceglie,Anna Pia Lasaracina et al.
Silvia Carnevale et al.
Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, me...
Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting? [0.03%]
白细胞介素-1介导的炎症记忆：保护性训练还是适应不良的肿瘤印迹？
Despoina Xanthopoulou,Maria Crespo,Lydia Kalafati
Despoina Xanthopoulou
Interleukin-1 (IL-1) exerts a pivotal role in the regulation of innate immune responses and inflammatory processes. Beyond its local effects at the site of inflammation, IL-1 acts as a systemic regulator of hematopoiesis by reprogramming he...
Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics [0.03%]
慢性压力在十字路口：解码炎症性肠病发病机制和治疗中的HPA-SAM-免疫-肠道轴
Ya-Fang Zhang,Yi-Yuan Li,Jin Jin
Ya-Fang Zhang
Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal ...
Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity [0.03%]
蛋白酪氨酸激酶在树突状细胞介导的抗肿瘤免疫中的作用
Misha Mao,Liwei Zhao,Guido Kroemer et al.
Misha Mao et al.
Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which i...
The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives [0.03%]
拉丁美洲和加勒比海地区的免疫系统：当地视角下的疾病与多样性研究展望
Ileana Licona-Limón,José Luis Maravillas-Montero,Maria Carolina Amezcua Vesely et al.
Ileana Licona-Limón et al.
Latin America and the Caribbean host one of the world's most complex intersections of ancestry, pathogen exposure, and environmental change, generating an immunological landscape that cannot be fully understood through frameworks derived fr...
Lionel Apetoh
Lionel Apetoh
Salma Ayman Khalefa,Moufida Ben Nasr,Vera Usuelli et al.
Salma Ayman Khalefa et al.
Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlight...
Interplay between viral oncolysis and host immunity in Newcastle disease virus-based cancer therapy [0.03%]
新城疫病毒抗癌治疗中的病毒溶瘤与宿主免疫的相互作用
Deepa Mehta,Shashi Gujar,Sachin Kumar
Deepa Mehta
Oncolytic virotherapy emerged as a revolutionary approach to immunotherapy in cancer treatment. Newcastle disease virus (NDV), a promising oncolytic agent of the Paramyxoviridae family, has gained considerable attention as an immunotherapeu...
Dendritic cells as central coordinators of oncolytic virus-induced antitumor immunity [0.03%]
树突状细胞在溶瘤病毒诱导的抗肿瘤免疫中的中心作用
Ehab M Ezzaldeen,Vishnu Vijay Vijayan,Preethi Gopalakrishnan Nair et al.
Ehab M Ezzaldeen et al.
Antigen-presenting cells shape the efficacy of cancer immunotherapies by providing essential signals required for antitumor T-cell response. Dendritic cells (DCs) are central to oncolytic virus (OV)-induced antitumor immunity because they c...
Latin American regional diversity of T-cell responses and cytokine immunoregulation in human Trypanosoma cruzi infection [0.03%]
人类克鲁兹锥虫感染中拉丁美洲T细胞区域多样性及细胞因子免疫调节差异性研究
Cristina Alonso-Vega,Juliana Assis Silva Gomes,Karina Andrea Gómez et al.
Cristina Alonso-Vega et al.
Chagas disease, caused by Trypanosoma cruzi, remains one of the most striking examples of how parasite genetic diversity and host immune heterogeneity converge to shape chronic infection outcomes. This review integrates findings from studie...