PKLR mutations in pyruvate kinase deficient Polish patients: Functional characteristics of c.101-1G > A and c.1058delAAG variants [0.03%]
波兰丙酮酸激酶缺乏症患者的PKLR突变：c.101-1G>A和c.1058delAAG变异的功能特征
Karolina Maciak,Aneta Jurkiewicz,Wojciech Strojny et al.
Karolina Maciak et al.
Pyruvate kinase (PK) deficiency is a rare autosomal recessive disorder characterized by chronic hemolytic anemia of variable severity. Nine Polish patients with severe hemolytic anemia but normal PK activity were found to carry mutations in...
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice [0.03%]
耐力训练和羟基脲对镰状细胞病小鼠肌肉功能和能量代谢的协同作用
Constance P Michel,Laurent A Messonnier,Benoit Giannesini et al.
Constance P Michel et al.
Sickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxyge...
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage [0.03%]
血小板活化与血液细胞外囊泡：静脉穿刺与短时间血液储存的影响
Ivica Marić,Klemen Žiberna,Ana Kolenc et al.
Ivica Marić et al.
Extracellular vesicles (EVs) as membrane-bound particles released by various cells are potential tools for diagnosis and treatment. Blood cells, particularly platelets, are the source of circulating EVs. ...
Commentary on "unmasking the morphological alteration of erythrocytes among women suffering from PCOS" [0.03%]
《揭开患有多囊卵巢综合征女性红细胞形态变化的面纱》评论
Shuwei Fan,Guomei Shi,Kelan Li
Shuwei Fan
Diamond-Blackfan anemia, the archetype of ribosomopathy: How distinct is it from the other constitutional ribosomopathies? [0.03%]
钻石-布莱克范贫血症，核糖体病的原型：它与其他先天性核糖体病有何不同？
L Da Costa,Narla Mohandas,Ludivine David-NGuyen et al.
L Da Costa et al.
Diamond-Blackfan anemia (DBA) was the first ribosomopathy described in humans. DBA is a congenital hypoplastic anemia, characterized by macrocytic aregenerative anemia, manifesting by differentiation blockage between the BFU-e/CFU-e develop...
Rare bleeding disorders: Real-world data from a Spanish tertiary hospital [0.03%]
罕见出血障碍：来自西班牙三级医院的真实世界数据
Daniel Martínez-Carballeira,Alberto Caro,Ángel Bernardo et al.
Daniel Martínez-Carballeira et al.
Introduction: Due to their low prevalence, rare bleeding disorders (RBDs) remain poorly characterized. Aim: To gain insight of RBDs thr...
Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications [0.03%]
JM-20对人血细胞的细胞毒性和致突变性的研究及其作为多靶点化合物的抗氧化前景和潜在治疗应用
Fernanda D&#x;Avila da Silva,Maria Eduarda de Andrade Galiciolli,Ana Carolina Irioda et al.
Fernanda D&#x;Avila da Silva et al.
JM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investiga...
A comparative study of two routinely used protocols for ex vivo erythroid differentiation [0.03%]
两种常规使用的红细胞体外分化方案的比较研究
Auria Godard,Robert Seute,Alexandra Grimaldi et al.
Auria Godard et al.
Background: Erythropoiesis is a complex developmental process in which a hematopoietic stem cell undergoes serial divisions and differentiates through well-defined stages to give rise to red blood cells. Over the last dec...
Regarding γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity [0.03%]
关于将γ'纤维蛋白原水平作为COVID-19呼吸疾病严重程度的生物标志物的问题
Lucy Z Kornblith,Bindhya Sadhanandhan,Sreepriya Arun et al.
Lucy Z Kornblith et al.