Surgical procedures and complications in placement of totally implantable venous access port in pediatric hemophilia patients: A retrospective analysis [0.03%]
儿童血友病患者植入式静脉输液港手术方式及并发症分析——回顾性研究
Wei Cheng,Jinrui Zhang,Xipeng Wang et al.
Wei Cheng et al.
This retrospective study at Beijing Children's Hospital (2020-2023) analyzed surgical procedures and complications in 24 pediatric hemophilia patients undergoing Totally Implantable Venous Access Port (TIVAP) insertion, primarily in the rig...
Mechanism of the apoptosis of bone marrow erythroblasts in rats under hypobaric hypoxia [0.03%]
缺氧条件下骨髓红细胞系凋亡的机制研究
Jie Ma,Shengyan Wang,Huihui Liu et al.
Jie Ma et al.
This study aimed to investigate the mechanism of the apoptosis of erythroblasts in rat bone marrow after the exposure to hypobaric hypoxia. Male SD rats were randomly divided into three groups. The hypoxic group was kept in a hypobaric hypo...
Differential effects of iron chelators on iron burden and long-term morbidity and mortality outcomes in a large cohort of transfusion-dependent β-thalassemia patients who remained on the same monotherapy over 10 years [0.03%]
不同铁螯合剂对大样本输血依赖性β-地中海贫血患者长期预后的影响：一项长达十年的单药治疗研究
Khaled M Musallam,Susanna Barella,Raffaella Origa et al.
Khaled M Musallam et al.
We conducted a retrospective cohort study on 663 transfusion-dependent β-thalassemia patients receiving the same iron chelation monotherapy with deferoxamine, deferiprone, or deferasirox for up to 10 years (median age 31.8 years, 49.9 % fe...
Aberrant baseline cytokine profile in patients with newly diagnosed acquired aplastic anaemia correlates with disease severity and the treatment response [0.03%]
新诊断获得性再生障碍性贫血患者的基线细胞因子谱异常与疾病严重程度及治疗反应相关
Rahul Vatsayan,Ankur Jain,Aditya Jandial et al.
Rahul Vatsayan et al.
Background: Immune dysregulation is crucial in the pathogenesis of acquired aplastic anaemia (aAA). There is paucity of data regarding correlation of baseline cytokine profile with treatment response in aAA. ...
Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation [0.03%]
Daucosterol通过调节JAK2-STAT3信号通路促进巨核细胞分化
Zhongkang Zhang,Guangbin Shang,Zhen Lu et al.
Zhongkang Zhang et al.
Immune thrombocytopenia (ITP) is an autoimmune disease caused by the loss of immune tolerance to platelet autoantigens, resulting in reduced platelet production and increased platelet destruction. Impaired megakaryocyte differentiation and ...
Matthew Hudkins,Heather Hamilton,Samantha J Underwood et al.
Matthew Hudkins et al.
COVID-19 disease progression can be accompanied by a "cytokine storm" that leads to secondary sequelae such as acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 disease progression, but h...
Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis [0.03%]
circ_0014614表达降低通过激活miR-138-5p/caspase3轴促进原发性血小板增多症骨髓系细胞向巨核细胞分化
Guopan Yu,Xiaofan Chen,Weixiang Lu et al.
Guopan Yu et al.
Background: Circular RNAs (circRNA) are pivotal in hematological diseases. Previous study showed that circ_0014614 (circDAP3) was significantly underexpressed in bone marrow-derived exosomes from essential thrombocythemia...
PKLR mutations in pyruvate kinase deficient Polish patients: Functional characteristics of c.101-1G > A and c.1058delAAG variants [0.03%]
波兰丙酮酸激酶缺乏症患者的PKLR突变：c.101-1G>A和c.1058delAAG变异的功能特征
Karolina Maciak,Aneta Jurkiewicz,Wojciech Strojny et al.
Karolina Maciak et al.
Pyruvate kinase (PK) deficiency is a rare autosomal recessive disorder characterized by chronic hemolytic anemia of variable severity. Nine Polish patients with severe hemolytic anemia but normal PK activity were found to carry mutations in...
Endurance training and hydroxyurea have synergistic effects on muscle function and energetics in sickle cell disease mice [0.03%]
耐力训练和羟基脲对镰状细胞病小鼠肌肉功能和能量代谢的协同作用
Constance P Michel,Laurent A Messonnier,Benoit Giannesini et al.
Constance P Michel et al.
Sickle cell disease (SCD) is an hemoglobinopathy resulting in the production of an abnormal Hb (HbS) which can polymerize in deoxygenated conditions, leading to the sickling of red blood cells (RBC). These alterations can decrease the oxyge...
Platelet activation and blood extracellular vesicles: The influence of venepuncture and short blood storage [0.03%]
血小板活化与血液细胞外囊泡：静脉穿刺与短时间血液储存的影响
Ivica Marić,Klemen Žiberna,Ana Kolenc et al.
Ivica Marić et al.
Extracellular vesicles (EVs) as membrane-bound particles released by various cells are potential tools for diagnosis and treatment. Blood cells, particularly platelets, are the source of circulating EVs. ...