Unveiling the role of RPS17 and SLC4A1 in diamond-Blackfan Anemia: A zebrafish-based study [0.03%]
RPS17和SLC4A1在黑扇贫血症中的作用揭示：一项斑马鱼研究
Kyeongmin Kim,Hyerin Lee,Soyul Ahn et al.
Kyeongmin Kim et al.
Diamond-Blackfan Anemia (DBA) is a rare congenital disorder characterized by macrocytic anemia, physical abnormalities, and growth delays. Although RPS19 mutations have been more extensively studied in DBA compared to other ribosomal protei...
Richard A King,Rami Khoriaty
Richard A King
Under steady state conditions, humans must produce ∼2 million red blood cells per second to sustain normal red blood cell counts and hemoglobin levels. Ineffective erythropoiesis, also termed dyserythropoiesis, is a process by which erythr...
Immunodeficiency in children with Diamond Blackfan and Diamond Blackfan like anemia [0.03%]
Diamond-Blackfan贫血和类似Diamond-Blackfan贫血患儿的免疫缺陷
Iman Ragab,Sara Makkeyah,Noura Hassan et al.
Iman Ragab et al.
Background: Diamond-Blackfan anemia Syndrome (DBAS) is a ribosomopathy with erythroid failure. DBA-like picture occurs with non-ribosomal mutation and a normal rRNA maturation. Immunodeficiency in patients with DBAS is no...
Red blood cell pyruvate kinase properties in Townes and Berkeley sickle cell disease mouse models - Of mice and men [0.03%]
Townes和Berkeley型镰状细胞病小鼠模型红细胞丙酮酸激酶的性质-谈小鼠与人
Marissa J M Traets,Titine J J Ruiter,Charles Levine et al.
Marissa J M Traets et al.
Pyruvate kinase (PK), a key ATP-generating enzyme in glycolysis, is a target for novel sickle cell disease (SCD) therapies. Enhancing PK activity lowers 2,3-diphosphyglycerate (2,3-DPG), increases adenosine triphosphate (ATP), and may preve...
Short- and long-term alterations of hematopoietic cell lineages in rats with congenital iron deficiency [0.03%]
先天性缺铁大鼠血细胞谱系的短期和长期改变
Anthony Babu,Zachary R Smith,Narmin Mukhtarova et al.
Anthony Babu et al.
Data support that fetal iron delivery is prioritized to hemoglobin in erythrocytes (RBC). Iron deficiency (ID) during pregnancy can cause congenital ID, i.e., low fetal iron acquisition. Because how congenital ID impacts other fetal hematop...
Marked microcytosis and increased transferrin saturation: Think about variants in SLC11A2 (DMT1) [0.03%]
SLC11A2(DMT1)基因突变导致的血红素合成异常：不宜单凭发现血清转铁蛋白饱和度增加和靶器官损伤而诊断铁粒幼细胞贫血
Alexandre Raynor,Katell Peoc&#x;h,Camille Boi et al.
Alexandre Raynor et al.
Congenital microcytic anemias are rare diseases associated with decreased hemoglobin synthesis and red blood cells of low corpuscular volume. DMT1/NRAMP2 is a highly conserved divalent cation transporter encoded by the SLC11A2 gene, express...
Corrigendum to "Clinical utility of relative telomere length analysis in pediatric bone marrow failure" [Blood Cells Mol. Dis. 109 (2024) 102882] [0.03%]
关于“儿科骨髓衰竭相对端粒长度分析的临床应用”一文的勘误[Blood Cells Mol. Dis. 109 (2024) 102882]
Shilpa Amatya,Prateek Bhatia,Sudhanshi Raina et al.
Shilpa Amatya et al.
Published Erratum
Blood cells, molecules & diseases. 2025 Feb:110:102899. DOI:10.1016/j.bcmd.2024.102899 2025
Identification of Nfel1a and Nfel3 as novel regulators for zebrafish thrombopoiesis [0.03%]
Nfel1a和Nfel3是斑马鱼巨核细胞产板型血小板生成的新调节因子
Weam Fallatah,Sanchi Dhinoja,Ayah Al Qaryoute et al.
Weam Fallatah et al.
In mammalian hematopoiesis, megakaryocytes mature and become polyploid in the bone marrow before releasing platelets into circulation. In contrast, fish produce thrombocytes in kidney marrow, where young thrombocytes undergo maturation in c...
Hemophagocytic lymphohistiocytosis associated with immune checkpoint inhibitor use: A review of the current knowledge and future directions [0.03%]
与免疫检查点抑制剂使用相关的噬血细胞综合征淋巴组织细胞增生症：当前知识和未来方向的回顾
Charlotte S Walmsley,Zachary Schoepflin,Charlotte De Brabandt et al.
Charlotte S Walmsley et al.
Hemophagocytic lymphohistiocytosis (HLH) is a severe and often lethal inflammatory syndrome characterized by excessive immune activation leading to fever, cytopenias, and multiorgan involvement. Immune checkpoint inhibitors (ICIs) are centr...
Further biological characterization of small molecules UM171 and SR1: In vitro effects on three hematopoietic cell populations from human cord blood [0.03%]
UM171和SR1的进一步生物学表征及其对人脐带血三种造血细胞群的体内影响
Patricia Flores-Guzman,Aranxa Torres-Caballero,Hector Mayani
Patricia Flores-Guzman
Small molecules UM171 and SR1 have already been taken into clinically-oriented protocols for the ex vivo expansion of hematopoietic stem (HSCs) and progenitor (HPCs) cells. In order to gain further insight into their biology, in the present...