Red blood cell pyruvate kinase properties in Townes and Berkeley sickle cell disease mouse models - Of mice and men
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Pyruvate kinase (PK), a key ATP-generating enzyme in glycolysis, is a target for novel sickle cell disease (SCD) therapies. Enhancing PK activity lowers 2,3-diphosphyglycerate (2,3-DPG), increases adenosine triphosphate (ATP), and may prevent red blood cell (R... ...
