Unveiling toxicological adverse outcomes: toward construction and simulation of large-scale networks [0.03%]
揭示毒理学不良反应：朝向大规模网络的构建与模拟
Nensi Ikonomi,Natalie Ketter,Mario A A Pepe
Nensi Ikonomi
Predicting toxicological adverse outcomes is crucial for advancing in silico toxicology strategies. Modern toxicology increasingly relies on systems biology approaches to model and interpret these outcomes. Adverse outcome pathways (AOPs) f...
Withdrawal interval estimations of oxytetracycline and chlortetracycline in swine using physiologically based pharmacokinetic models: a global trade perspective [0.03%]
基于生理的药代动力学模型在生猪中估计oxytetracycline和chlortetracycline的停药期：全球贸易视角
Kun Mi,Hiroko Enomoto,Ronald E Baynes et al.
Kun Mi et al.
Violative drug residues in animal-derived food are a global food safety concern. Physiologically based pharmacokinetic (PBPK) modeling is a valuable tool for predicting drug residues in edible tissues and determining withdrawal intervals (W...
Repeated bronchoalveolar lavage variability and impact in a 2-week nonclinical toxicology study [0.03%]
重复支气管肺泡灌洗的变异性和影响以及为期两周的非临床毒理学研究中的作用
Emily Hackshaw,James Nelson,Molly H Boyle
Emily Hackshaw
Nonclinical inhalation studies often rely on systemic biomarkers of exposure and pharmacology for serial evaluations, since local pulmonary effects are generally limited to assessment by terminal procedures. In addition, invasive procedures...
Role of hemopexin in protoporphyrin IX distribution and cholestatic liver injury [0.03%]
血红素结合蛋白在原卟啉Ⅸ分布和胆汁淤积性肝损伤中的作用
Ruizhi Gu,Fu-Ying Qin,Zeyu Sun et al.
Ruizhi Gu et al.
Deficiency of ferrochelatase (FECH) in erythropoietic protoporphyria (EPP) leads to accumulation of its substrate, protoporphyrin IX (PPIX), the final intermediate in the heme biosynthesis pathway. PPIX is produced primarily in the bone mar...
An AOP-aligned ex vivo mouse testicular organ culture platform for mechanistic integration of multi-level endpoints with recovery assessment [0.03%]
一种基于AOP的体外小鼠睾丸器官培养平台 可实现多层面终点的机制整合与恢复评估
Hideaki Nakagiri,Kyoichi Kodama,Shimpei Terasaka et al.
Hideaki Nakagiri et al.
Mechanistic understanding is important for improving the safety assessment of male reproductive toxicity; however, current evaluations still rely primarily on ex vivo studies. Therefore, the development of new approach methodologies (NAMs) ...
Quantitative Estimates of Inter-individual Variability for New Approach Methodologies-Based Systemic Safety Toolbox Using a Population-Based Human in Vitro Model [0.03%]
基于人群的体外模型对于新方法体系安全工具箱人与人之间差异定量评估的研究
Ibrahim Alshammari,Lucie C Ford,Han-Hsuan D Tsai et al.
Ibrahim Alshammari et al.
Next-Generation Risk Assessment (NGRA) frameworks use New Approach Methodologies (NAMs) to support regulatory decisions without animal testing. While NAM-based approaches are well established for hazard and dose-response assessment, inter-i...
In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure [0.03%]
预测癫痫风险的氟喹诺酮和非甾体抗炎药相互作用的体外和临床前评估
Yuki Seki,Ikue Mihara,Taroumaru Okawa et al.
Yuki Seki et al.
Seizures are a common reason for drugs to fail during development, but they are difficult to predict preclinically. Enoxacin, a fluoroquinolone, rarely causes convulsions as a monotherapy, but convulsions have been seen after combination th...
Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations [0.03%]
卵巢激素缺乏通过转录组学和代谢改变增强木烟引起的免疫功能障碍
Mijung Oh,Sydnee Yazzie,Eunju Lim et al.
Mijung Oh et al.
The increasing frequency and severity of wildfires have heightened public exposure to smoke, highlighting the importance of identifying susceptibility factors, including ovarian hormone deficiency. Here, we used single-cell RNA sequencing t...
Isolated and Combined Exposure to Polystyrene Nanoplastics and a Phthalate Metabolite Mixture Disrupt Antral Follicle Growth and Function of Mice In Vitro [0.03%]
聚苯乙烯纳米塑料和邻苯二甲酸盐代谢物混合物的单独及联合暴露会破坏小鼠体内窦状卵泡的生长和功能
Patrick V Souza,Ramsés Santacruz-Márquez,Mary J Laws et al.
Patrick V Souza et al.
Polystyrene nanoplastics (PS-NPs) are small particles derived from plastic degradation that have been detected in several human tissues. Phthalates are ubiquitous plasticizers used to increase flexibility in polymers which act as endocrine ...
Temporal variation in markers of immune signaling and wound repair in primary human airway epithelial cells following acute vs. repeated woodsmoke condensate exposure [0.03%]
一次或重复暴露于木材烟雾冷凝物后原代人支气管上皮细胞中免疫信号和伤口修复标志物的动态变化规律
Elise Hickman,Chloe Chou,Cole Seifert et al.
Elise Hickman et al.
Wildfire smoke (WFS) exposures are becoming more common, and firefighters and community members are often exposed to WFS for days to weeks. Controlled studies assessing the effects of repeated exposure to WFS and woodsmoke (WS; as a surroga...