Metabolic and Circadian Bioenergetic Alterations Following PFOA Exposure and High-Fat Diet in Female C57BL/6 Mice [0.03%]
全氟辛酸暴露和高脂饮食对C57BL/6雌性小鼠代谢及昼夜生物节律的影响
Aya Ahmed,Matthew Wittenborn,Jamie DeWitt et al.
Aya Ahmed et al.
Exposure to per- and polyfluoroalkyl substances (PFAS) elicits changes in various metabolic responses but few studies have evaluated whole-body metabolic changes. This study compared whole-body bioenergetics in adult female C57BL/6 mice ora...
Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin [0.03%]
人源微生物组(SIHUMIx)和斑马鱼模型的整合揭示了微生物介导的多菌唑宿主反应
Chloe Wray,Victor Castañeda-Monsalve,Beatrice Engelmann et al.
Chloe Wray et al.
The gut microbiome is essential for neurodevelopment via bidirectional gut-brain axis signaling, yet environmental chemicals can potentially disrupt this communication by altering community structure and xenobiotic metabolism. In this study...
Multimodal Preclinical Assessment of Glucocorticoid-Induced Disruption of Bone Remodeling in Sprague-Dawley Rats [0.03%]
多模式预临床评估糖皮质激素诱导的Sprague-Dawley大鼠骨重塑紊乱的作用
Anik Tuladhar,Caitlyn Carter,Erin Vaughan et al.
Anik Tuladhar et al.
Skeletal toxicity is a critical consideration during drug development arising from on-target mechanisms and off-target effects. Standard histopathology used in preclinical toxicity studies lacks sensitivity to detect subtle skeletal alterat...
Exposure of endothelial cells to Doxorubicin inhibits Extracellular matrix production by dermal fibroblasts in a paracrine manner [0.03%]
表柔比星抑制内皮细胞旁分泌诱导皮肤纤维化
Zhu Jiang,Giulia Sorrentino,Madalena Lopes Natário Pinto et al.
Zhu Jiang et al.
Doxorubicin (Dox) is a potent chemotherapeutic with known vascular toxicity and connective-tissue damage. Endothelial cells (EC) and fibroblasts crosstalk is essential for vascular homeostasis and extracellular matrix (ECM) remodeling. This...
Safetyome and Specialized Panels for Over 3,000 Phenotypes: a Systematic and Translational Approach using Human Genetics and Pharmacology [0.03%]
利用人类遗传学和药理学进行的系统性和转化性方法构建超过3000种表型的安全组与专业面板
Xin Liu,Yen-Wei Chen,Xiao Xu et al.
Xin Liu et al.
Drug candidates are often evaluated for their activities against unexpected targets (off-targets), to either prospectively flag potential hazards or to provide mechanistic insights for a given phenotype. The in vitro to in vivo translatabil...
Acute exposure to Diethylhexyl phthalate (DEHP) and Diisononyl phthalate (DiNP) impacts pituitary hormones and inflammatory markers, suggesting altered reproductive aging in adult female mice [0.03%]
Yinka Ojo,Karen Weis,Mary Laws et al.
Yinka Ojo et al.
Phthalates are ubiquitous endocrine-disrupting chemicals whose exposure is associated with accelerated reproductive aging in humans. We focused on the pituitary gland, the source of the gonadotropins: Follicle-stimulating hormone (FSH) and ...
Short-term electrical stimulation promotes partial functional and morphological maturation of human-induced pluripotent stem cell-derived cardiomyocytes enabling cardiotoxicity risk mitigation at early-stage drug discovery for cardiac contractility modulation [0.03%]
短期电刺激促进人诱导多能干细胞源性心肌细胞的功能和形态成熟，从而在心脏收缩力调节的早期药物发现阶段降低 cardiotoxicity 风险
Hayato Miyoshi,Kaoru Morimura,Reiko Hara et al.
Hayato Miyoshi et al.
In drug discovery, assessing cardiac contractile force is crucial because of its association with the development of cardiovascular events and heart failure. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a p...
Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants [0.03%]
自然差异表明了候选基因决定了秀丽隐杆线虫对多种毒物的易感性
Timothy A Crombie,Ryan Mckeown,Samuel J Widmayer et al.
Timothy A Crombie et al.
Genetic differences among individuals shape how they respond to environmental toxicants, but the identification and validation of the genes responsible for this variation is difficult, particularly in humans. Consequently, our limited knowl...
Application of In Vitro to In Vivo Extrapolation (IVIVE) to Inform Chemical Health Guidance Values Derivation - Sample Case Studies Comparing Neuro-, Hepato-, and Developmental Toxicities [0.03%]
从体外到体内的转化应用于化学品健康指导值的制定-神经毒性、肝毒性和发育毒性的案例比较研究
Xiaoqing Chang,David G Allen,Nicole C Kleinstreuer et al.
Xiaoqing Chang et al.
Traditional chemical risk assessment is often based on published mammalian in vivo toxicity data, which are used to identify a point-of-departure (PoD) to derive the minimal risk level (MRL) and similar health guidance values. However, time...
ToxPoint: The Case Study for Respiratory Sensitization Assessment of Methyl Methacrylate using New Approach Methodologies [0.03%]
甲基丙烯酸甲酯呼吸致敏性评估的案例研究-ToxPoint应用
Frank Faulhammer,Susanne N Kolle,Karin Wiench
Frank Faulhammer