MEHP exposure damages the basement membrane by suppressing the expression of its constituent proteins in peritubular myoid cells of the rat testis [0.03%]
MEHP暴露通过抑制大鼠睾丸管周平滑肌样细胞基底膜成分蛋白的表达损害其基底膜
Narayan Acharya,John H Richburg
Narayan Acharya
The basement membrane (BM) is a crucial support structure of the seminiferous epithelium, mainly made up of collagens, fibronectin, laminins, and proteoglycans. Along with the collagen fiber network, the peritubular myoid cell (PTMC) forms ...
Words Matter in Toxicology and Risk Assessment as They Impact Risk Communication [0.03%]
毒理学和风险评估中的用词对风险交流的影响不容忽视
Curtis D Klaassen
Curtis D Klaassen
Clear, consistent language is essential in toxicology and risk assessment because terminology directly affects risk communication and understanding. The original concept of a "No Harm Dose of Reasonable Certainty" (NHDoRC) for an amount of ...
Tetrabromobisphenol S (TBBPS)-induced developmental toxicity in zebrafish embryos: impacts on cytoskeletal proteins during gastrulation [0.03%]
四溴双酚S(TBBPS)诱导的斑马鱼胚胎发育毒性：对原肠胚形成期间细胞骨架蛋白的影响
Rosemaria Serradimigni,Heidi M Sabatini,Christopher Chouinard et al.
Rosemaria Serradimigni et al.
3,3',5,5'-Tetrabromobisphenol S (TBBPS) is an emerging brominated flame retardant that is widely detected in the environment, yet its toxic effects remain poorly understood. The objective of this study was to use zebrafish as a model and de...
Hepatic inflammation after exposure to a mixture of low-dose arsenic and cadmium in a murine model of fatty liver disease [0.03%]
小鼠脂肪肝疾病模型中低剂量砷和镉混合暴露后的肝脏炎症反应
Nivetha K Subramaniam,Natascha Gagnon,Cynthia Guilbert et al.
Nivetha K Subramaniam et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden and major contributor to chronic liver disease. Evidence suggests arsenic (As) and/or cadmium (Cd) exposure may influence MASLD development, ...
Pulmonary Vascular Remodeling in Rats Following Methamphetamine Self-Administration: Toward a Model of Methamphetamine-Associated Pulmonary Arterial Hypertension [0.03%]
甲基苯丙胺自给引起的肺血管重塑：向甲基苯丙胺相关肺动脉高压模型迈进
Prangthip Charoenpong,Nicole M Hall,Courtney M Keller et al.
Prangthip Charoenpong et al.
Background: Pulmonary arterial hypertension (PAH) is a progressive vasculopathy characterized by pulmonary vascular remodeling. Methamphetamine (MA) exposure is strongly associated with PAH in humans, yet prior animal mod...
UVB Light Activates an S Phase-Dependent DNA Damage Response in Human Keratinocytes Independent of Oxidative Stress [0.03%]
UVB通过独立于氧化应激的S期依赖性途径诱导人角质形成细胞DNA损伤反应
Yunqi An,Yi-Hua Jan,Jeffrey D Laskin
Yunqi An
Ultraviolet B (UVB; 280-320 nm) radiation damages DNA in epidermal cells and contributes to the development of skin cancer. In response, keratinocytes activate a DNA damage response (DDR) that regulates DNA repair through signaling pathways...
Disease-dependent airway epithelial responses to acute electronic cigarette aerosol exposure: a pilot single-cell analysis [0.03%]
针对急性电子烟气溶胶暴露的呼吸道上皮细胞的疾病依赖性单细胞分析研究
Courtney Van,Pin-Hsun Mao,Jackie Nguyen et al.
Courtney Van et al.
Electronic cigarette (e-cig) use is increasingly common among individuals with asthma, yet the cell type-specific airway responses to e-cig exposure remain poorly understood. Because asthma is characterized by altered epithelial composition...
Airborne contaminant exposure and bone development: A systematic review and meta-analysis [0.03%]
关于空气污染物暴露与骨骼发育关系的系统评价和meta分析
Madeline K M Vera-Colón,Ruth M Meletz,Celina N Phillipson et al.
Madeline K M Vera-Colón et al.
Air pollution, including particulate matter (PM10, PM2.5) and airborne metals (Cd, Hg, As, Pb) are a systemic health hazard, but osteotoxic effects remain underrecognized. We systematically synthesized human, animal, and in vitro evidence o...
Artificial Intelligence-Augmented Mixture Toxicology: Reframing Unresolved Risk at Camp Lejeune [0.03%]
人工智能增强的混合毒理学：重新审视勒琼营未解的风险问题
Peter Pressman,A Wallace Hayes
Peter Pressman
Persistent uncertainty regarding health risks associated with contaminated drinking water at Camp Lejeune reflects a broader limitation in toxicology: The difficulty of evaluating complex chemical mixtures in genetically heterogeneous popul...
Do metals in tampons pose a health risk? A toxicological risk assessment study [0.03%]
金属卫生棉条有害健康吗？一项毒理风险评估研究
Ying Jin,Michael Eppihimer,Md Shah Alam et al.
Ying Jin et al.
Recently concern has been raised over metal content in tampons and the possibility of toxicological risk to women. As a result, researchers at the United States Food and Drug Administration (FDA) investigated metals present in tampons and e...