In vitro and preclinical assessment of drug interactions between fluoroquinolones and a non-steroidal anti-inflammatory drug predicting risk of seizure
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Seizures are a common reason for drugs to fail during development, but they are difficult to predict preclinically. Enoxacin, a fluoroquinolone, rarely causes convulsions as a monotherapy, but convulsions have been seen after combination therapy with fenbufen,... ...
