The neurotoxic mechanism of Jack Bean Urease in insects involves the interplay between octopaminergic and dopaminergic pathways [0.03%]
刀豆尿酶对昆虫的神经毒性机制涉及章鱼胺能和多巴胺能通路之间的相互作用
Yuri Correia Barreto,Raquel Soares Oliveira,Bruna Trindade Borges et al.
Yuri Correia Barreto et al.
In the last decades, the entomotoxicity of JBU and its derived peptides became an object of study, due mainly to the ubiquitous interaction of these compounds with different species of insects and their potential as natural insecticides. In...
Characterization of mutants with single and combined Qi and Qo site mutations in Saccharomyces cerevisiae reveals interactions between the picolinamide fungicide CAS-649 and azoxystrobin [0.03%]
Saccharomyces cerevisiae中单个和组合的Qi位点和Qo位点突变的突变体的特征表明，噁草酸与杀菌剂CAS-649之间的相互作用
David H Young,Brigitte Meunier
David H Young
Picolinamide and strobilurin fungicides bind to the Qi and Qo sites on cytochrome b, respectively, and target many of the same plant pathogens. Using Saccharomyces cerevisiae as a model system, we explore effects of amino acid changes at ea...
Integrated transcriptomic-metabolomic analysis reveals that cinnamaldehyde exposure positively regulates the phenylpropanoid pathway in postharvest Satsuma mandarin (Citrus unshiu) [0.03%]
整合转录组和代谢组分析显示肉桂醛暴露能促进采后果实（香橙）中苯丙素途径的表达
Bin Duan,Xiaoli Tan,Jianyuan Long et al.
Bin Duan et al.
Previously, wax + cinnamaldehyde (WCA) was proven to be able to effectively alleviate fruit decay and induce resistance in harvested Satsuma mandarin (Citrus unshiu). However, the potential molecular mechanism is largely unknown. In the pre...
Ecogenotoxicity of environmentally relevant atrazine concentrations: A threat to aquatic bioindicators [0.03%]
环境相关莠去津浓度的生态遗传毒性：对水生生物指标的威胁
Victor Ventura de Souza,Tatiana da Silva Souza,José Marcello Salabert de Campos et al.
Victor Ventura de Souza et al.
Atrazine (ATZ) is a herbicide that is frequently present in surface waters and may result in damage to the health of various organisms, including humans. However, most scientific literature reports injuries caused by ATZ at high concentrati...
Determination of potential toxicodynamic differences of pyrethroid insecticides on native voltage-sensitive sodium channels in juvenile versus adult rat brain [0.03%]
吡虫啉杀虫剂对幼年与成年大鼠脑源电压敏感性钠通道潜在毒动态差异的确定
Steven B Symington,Abigail C Toltin,Edwin Murenzi et al.
Steven B Symington et al.
Microtransplantation of neurolemma tissue fragments from mammalian brain into the plasma membrane of Xenopus laevis oocytes is a tool to examine the endogenous structure and function of various ion channels and receptors associated with the...
Topical delivery of dsRNA in two hemipteran species: Evaluation of RNAi specificity and non-target effects [0.03%]
两种半翅目昆虫物种中的dsRNA专题递送：RNA干扰特异性及非靶标效应评估
Luca Finetti,Lorenzo Benetti,Jimena Leyria et al.
Luca Finetti et al.
Double-stranded (ds) RNA-based technologies could provide novel and potential tool for pest management with efficiency and specificity of action. However, before applying this technique in the field, it is necessary to identify effective de...
Protective effect of rutin against thiram-induced cytotoxicity and oxidative damage in human erythrocytes [0.03%]
芦丁对硫iram诱导的人红细胞毒性及氧化损伤的保护作用
Samreen Salam,Amin Arif,Monika Sharma et al.
Samreen Salam et al.
Thiram is a fungicide that is used to prevent fungal diseases in seeds and crops and also as an animal repellent. The pro-oxidant activity of thiram is well established. Rutin is a flavonoid glycoside present in many fruits and plants and h...
Chitosan nanocarriers mediated dsRNA delivery in gene silencing for Helicoverpa armigera biocontrol [0.03%]
几丁质纳米载体介导的双链RNA递送用于棉红铃虫基因沉默生物防治中的基因沉默
Henry Kolge,Kartiki Kadam,Vandana Ghormade
Henry Kolge
Specific gene silencing by RNA interference (RNAi) involving exogenous double stranded RNA (dsRNA) delivery has potential in Helicoverpa armigera control, a resistant insect pest. Here, ionotropically synthesized cationic chitosan nanoparti...
Behavioral and neurochemical impairments after intranasal administration of chlorpyrifos formulation in mice [0.03%]
氯吡硫磷制剂经鼻腔给药对小鼠行为和神经化学的影响
Cristina Eugenia Gallegos,Mariana Bartos,Fernanda Gumilar et al.
Cristina Eugenia Gallegos et al.
Among the most relevant environmental factors associated with the etiology of neurodegenerative disorders are pesticides. Spray drift or volatilization generates pesticide dispersion after its application. In addition, inhalation or intrana...
Yu Wang,Hongyi Song,Sheng Wang et al.
Yu Wang et al.
With the aim of discovering novel nematicidal scaffolds, the nematicidal activities of a series of quinazoline compounds were tested, with some compounds showing excellent results. Among them, the LC50 values of compound K11 against Bursaph...