Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging [0.03%]
甾体激素对雌性成年啮齿类动物发情周期、妊娠期、哺乳期及衰老期间海马神经发生的作用
Jodi L Pawluski,Susanne Brummelte,Cindy K Barha et al.
Jodi L Pawluski et al.
Adult neurogenesis exists in most mammalian species, including humans, in two main areas: the subventricular zone (new cells migrate to the olfactory bulbs) and the dentate gyrus of the hippocampus. Many factors affect neurogenesis in the h...
New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm [0.03%]
胆固醇和性类固醇的神经保护作用的新观点：Seladin-1/DHCR24模式
Alessandro Peri,Giovanna Danza,Susanna Benvenuti et al.
Alessandro Peri et al.
In 2000 a new gene, i.e. seladin-1 (for selective Alzheimer's disease indicator-1) was identified and found to be down regulated in vulnerable brain regions in Alzheimer's disease. Seladin-1 was considered a novel neuroprotective factor, be...
Dominique J-F de Quervain,Amanda Aerni,Gustav Schelling et al.
Dominique J-F de Quervain et al.
Over the last decades considerable evidence has accumulated indicating that glucocorticoids - stress hormones released from the adrenal cortex - are crucially involved in the regulation of memory. Specifically, glucocorticoids have been sho...
Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models? [0.03%]
早期生活压力、攻击行为的发展以及神经内分泌和神经生物学的关联：我们可以从动物模型中得到什么启示？
Alexa H Veenema
Alexa H Veenema
Early life stress (child and adolescent abuse, neglect and trauma) induces robust alterations in emotional and social functioning resulting in enhanced risk for the development of psychopathologies such as mood and aggressive disorders. Her...
Christopher M Mayer,Laura J Fick,Sarah Gingerich et al.
Christopher M Mayer et al.
The hypothalamus is the control center for most physiological processes; yet has been difficult to study due to the inherent heterogeneity of this brain region. For this reason, researchers have turned towards cell models. Primary hypothala...
Haifei Shi,Randy J Seeley,Deborah J Clegg
Haifei Shi
The prevalence of obesity has reached epidemic proportion with enormous costs in both human lives and healthcare dollars spent. Obesity-related metabolic disorders are much lower in premenopausal women than men; however, there is a dramatic...
Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration [0.03%]
孕酮在创伤性中枢神经系统损伤和运动神经元退变中的神经保护作用
Alejandro F De Nicola,Florencia Labombarda,Maria Claudia Gonzalez Deniselle et al.
Alejandro F De Nicola et al.
Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote rem...
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) [0.03%]
脱氢表雄酮(DHEA)和硫酸脱氢表雄酮(DHEAS)的神经生物学和神经精神作用
Nicole Maninger,Owen M Wolkowitz,Victor I Reus et al.
Nicole Maninger et al.
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormone...
What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? [0.03%]
"四种核心基因型"小鼠模型告诉我们关于大脑及其他组织中的性别差异的哪些信息？
Arthur P Arnold,Xuqi Chen
Arthur P Arnold
The "four core genotypes" (FCG) model comprises mice in which sex chromosome complement (XX vs. XY) is unrelated to the animal's gonadal sex. The four genotypes are XX gonadal males or females, and XY gonadal males or females. The model all...
Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats [0.03%]
大鼠母性行为的发生和维持过程中与中隔前核-多巴胺能神经系统相互作用的关系研究
Michael Numan,Danielle S Stolzenberg
Michael Numan
The medial preoptic area (MPOA) and dopamine (DA) neural systems interact to regulate maternal behavior in rats. Two DA systems are involved: the mesolimbic DA system and the incerto-hypothalamic DA system. The hormonally primed MPOA regula...