Dramatic sex differences leading to different brain disease presentation: The requirement for sex-specific medications with ADNP/davunetide as a case study [0.03%]
性别差异导致的脑部疾病表现不同及特异性药物需求：ADNP/DAVUNETIDE 的研究案例
Alexandra Lobyntseva,Liri Sophia Guz,Artur Galushkin et al.
Alexandra Lobyntseva et al.
Focusing on the brain-essential gene revealed in our laboratory, activity-dependent neuroprotective protein (ADNP) and its neuroprotective site, the investigational drug davunetide (NAP), we discuss ADNP regulating steroid hormone biosynthe...
Freezing as a measure of fear: sex differences and implications for preclinical research [0.03%]
冷作为恐惧的衡量标准：性别差异及其对临床前研究的意义
Yuchen Sun,Yiyang Sun,Ruoming Wang et al.
Yuchen Sun et al.
Rodent fear conditioning paradigms are widely used to model core features of posttraumatic stress disorder (PTSD), with freezing behaviour serving as the dominant readout. However, the extent to which freezing captures biologically and clin...
The Subfornical organ: A central target for renin-angiotensin system regulation [0.03%]
后小脑下区：肾素-血管紧张素系统调节的中枢靶点
Fatemeh Mollaei,Sara Rahmati,Farzaneh Ahmadi Fordooii et al.
Fatemeh Mollaei et al.
The renin-angiotensin system (RAS) is a pivotal system for regulating blood volume, electrolyte balance, and systemic vascular resistance. The system exerts its functions through various central targets, particularly those located in the br...
Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications [0.03%]
大脑中的类固醇5α还原酶：从神经固醇生物合成到治疗意义
Giulia Braccagni,Caterina Branca,Marco Bortolato
Giulia Braccagni
Steroid 5α-reductases (5αRs) catalyze the irreversible, NADPH-dependent reduction of Δ4-3-ketosteroids. This process regulates major steroid signaling pathways, including neurosteroid biosynthesis, androgen activation, and glucocorticoid...
Light, melanin, and the microbial clock: Rewiring the gut-brain-skin axis [0.03%]
光、黑色素和微生物钟：重新布线肠-脑-皮肤轴
Allison Clark,Núria Mach
Allison Clark
Sunlight exposure has shaped the evolutionary biology of most life forms through circadian entrainment. Full-spectrum sunlight regulates circadian rhythms, modulates gut and skin microbiomes, influences the gut-brain-skin axis, and drives d...
Neuroendocrine mechanisms of stress-induced KNDy-GnRH pulse generator suppression: Linking HPA-axis activation to female reproductive dysfunction [0.03%]
应激通过神经内分泌机制抑制KNDy- GnRH脉冲发生器的生成：将HPA轴激活与女性生殖功能障碍联系起来
Wenjie Bo,Yujing Li,Ruiying Wang et al.
Wenjie Bo et al.
Chronic stress disrupts female reproductive function, but the central mechanisms linking stress exposure to altered gonadotropin-releasing hormone (GnRH) pulsatility remain incompletely defined. The arcuate kisspeptin/neurokinin B/dynorphin...
Aging-related autonomic nervous system imbalance and adrenergic regulation of immunity: Implications for inflammaging, autoimmunity, and long COVID [0.03%]
衰老相关的自主神经系统失衡和肾上腺素对免疫系统的调节：慢性炎症、自身免疫及长新冠的潜在影响
Sergio Giunta,Jacopo Sabbatinelli,Fabiola Olivieri et al.
Sergio Giunta et al.
The autonomic nervous system (ANS) plays a central role in immune homeostasis by integrating sympathetic and parasympathetic signals that regulate inflammation, immune cell trafficking, and tolerance. Aging is associated with a progressive ...
Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease [0.03%]
纳米和微塑料作为神经活性类固醇的作用物质及其对大脑功能和疾病的影响研究
Patrizia Porcu,Mariangela Serra,Augusta Pisanu et al.
Patrizia Porcu et al.
Among environmental pollutants, microplastics (MPs) and nanoplastics (NPs) represent a major threat to marine and terrestrial ecosystems because of their widespread distribution, environmental persistence, accumulation in animal and human o...
Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research [0.03%]
肌痛性脑脊髓炎和长期新冠肺炎中的系统神经内分泌学：一种基于激素研究的生物钟生物学框架
Natalie Thomas,Katherine Huang,Elena K Schneider-Futschik et al.
Natalie Thomas et al.
Hormonal dysregulation is increasingly reported in ME/CFS and Long COVID, yet the broader role of neuroendocrine disruption in these conditions remains underexplored. While changes in steroid, peptide, and neuropeptide hormones have been id...
N-methyl-d-aspartate receptor subunits interacting with regulators mediate neuropathic pain: from mechanisms to therapy [0.03%]
与调控分子相互作用的N-甲基-D天冬氨酸受体亚单位介导神经病理性疼痛：从机制到治疗
Junzi Peng,Pengcheng Yi,Yan Tian et al.
Junzi Peng et al.
NMDARs and their interacting proteins drive central sensitization in neuropathic pain, yet their pathological effects are critically shaped by upstream neuroendocrine regulators. This review synthesizes evidence across three dimensions: (i)...