In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals [0.03%]
尿管上皮细胞和远端肾小管之间的身份和成熟度的可塑性受外在信号控制
Pamela Kairath,Pei Xuan Er,Sean Wilson et al.
Pamela Kairath et al.
Several studies have described human pluripotent stem cell (hPSC)-derived ureteric epithelium, which in the embryo arises from the nephric duct and forms the collecting ducts of the kidney. However, hPSC-derived distal nephron epithelium ca...
Identification of evolutionary conserved and diverged regulatory elements of embryonic Msx1 expression among amniote species via 3D-genome analyses and in vivo assays [0.03%]
利用三维基因组分析和体内实验鉴定顶小骨蛋白1在羊膜动物胚胎表达中保守与分化出的调控元件
Yoshio Wakamatsu,Yukiko U Inoue,Shyu Manabe et al.
Yoshio Wakamatsu et al.
The Msx1 gene encodes a homeobox transcription factor that regulates numerous patterning events during the development of organs such as the limb bud and jaw primordium. In craniofacial development, Msx1 is involved not only in the proximal...
High-Sensitivity In Situ Detection of Sox21 Reveals Transcript Asymmetry from the Zygote Stage [0.03%]
高灵敏性原位检测SOX21揭示了从受精卵阶段开始的转录不对称性
Estefania Sanchez-Vasquez,Gyda Nawarungruang,Maciej Meglicki et al.
Estefania Sanchez-Vasquez et al.
The first lineage decision in mammalian development segregates embryonic and extra-embryonic fates, yet the timing of this specification remains under debate. While our previous lineage tracing studies in mice and human suggested that this ...
Deciphering the Single-Cell Transcriptomic Atlas of Donkey (Equus asinus) Gonad Development in Early Gestation [0.03%]
用于早期妊娠时期驴（Equus asinus）生殖腺发育的单细胞转录组图谱解析
Yadan Jin,Huajie Zhang,Ruixue Ma et al.
Yadan Jin et al.
In donkey reproduction, the extended reproductive cycle is a pivotal factor contributing to the low reproductive rate. Gonadal development represents a highly complex biological process that involves sex determination and subsequent progres...
Did the evolution of multiple microchromosomes help save bird and other dinosaurs from extinction? [0.03%]
多条微染色体的进化帮助鸟类和其他恐龙免于灭绝了吗？
Darren K Griffin,Rafael Kretschmer,Denis M Larkin et al.
Darren K Griffin et al.
Birds currently number ∼11,000 species and, despite enormous biodiversity, have numerous class-specific characteristics including feathers, flight, nesting, brooding, longevity and a very distinctive karyotype. Central to several academic ...
Tbx genes influence early gene expression and photoreceptor patterning in the chick retina [0.03%]
T盒基因影响鸡视网膜早期基因表达和光感受器的模式化
Monika Ayten,Heer N V Joisher,Chaitra Prabhakara et al.
Monika Ayten et al.
The retina, our sensory organ for vision, displays distinct photoreceptor distributions and can have a specialized region for high visual acuity. The establishment of these spatial patterns during development depends on regionally restricte...
Molecular Regulation of Telomeric Elongation and TERT Splicing in Planarians [0.03%]
涡虫染色体端粒延长及TERT拼接的分子调控
William Diaz,Claudia M Arenas-Gomez
William Diaz
Planarians, flatworms renowned for their extraordinary regenerative capacity, depend on a population of adult pluripotent stem cells known as neoblasts. Unlike most adult stem cells in mammals, neoblasts maintain sustained telomerase activi...
Mediolateral neural patterning during gastrulation precedes dorsoventral patterning in chick and frog [0.03%]
鸡和蛙胚胎原肠胚期的中间侧神经嵴模式化早于背部腹部模式化发生的时间
Laila-Zoe Tirilomis,Stanislav Kremnyov,Natalia Petri et al.
Laila-Zoe Tirilomis et al.
Introduction: dorsoventral polarity of the neural tube is based on molecular patterning established during neurulation and is suggested to be induced by fine-tuned interpretation of opposing morphogen gradients in the neu...
Crosstalk between corticosterone and triiodothyronine signaling in Xenopus tropicalis hindlimb buds [0.03%]
非洲爪蟾后肢芽中皮质酮和三碘甲状腺原氨酸信号之间的串扰
Alexis Grimaldi,Muriel Rigolet,Corinne Blugeon et al.
Alexis Grimaldi et al.
Thyroid hormone signaling has a wide range of biological effects involved in the control of homeostasis and development. In amphibian, thyroid hormones control the onset of metamorphosis, which resemble the mammalian perinatal period. Gluco...
Leonardo Tadini,Lilia Younsi,Isabel Holguera et al.
Leonardo Tadini et al.
Brains are complex structures comprising thousands to billions of neurons that belong to thousands of different neuronal types. These neurons often come from different progenitor domains and have very diverse developmental histories, yet th...