Introduction to Developmental Biology Special Issue: Extraembryonic Tissues - Perspectives [0.03%]
发育生物学专刊：额外胚胎组织-新视角介绍
Karen M Downs
Karen M Downs
Neuron-originated Dachshund regulates tracheal tubulogenesis via Lola-Slit axis in Drosophila [0.03%]
神经源Dachshund通过Lola-Slit轴调控果蝇气管发育中的管腔形成
Junzhi Zhu,Wenshuo Zhang,Bo Dong
Junzhi Zhu
Abnormal morphogenesis causes dysfunction of biological tubes and thus is associated with various diseases. However, the underlying regulatory mechanisms for biological tubulogenesis are not fully understood, especially on the cooperation a...
Bioelectric control of tissue mechanics: Effect of membrane potential on somite deformability in chick embryos [0.03%]
生物电对组织力学的控制：膜电位对鸡胚节片变形性的影响
Manohara Mahadeva,Sebastian Niestępski,Magdalena Kowacz
Manohara Mahadeva
Somite segmentation is a crucial process during early embryogenesis, where the timing of somite emergence and somite growth have to be precisely coordinated. Our recent findings established membrane potential (Vm) as a key factor that synch...
Dynamic remodeling of epithelial junctions in trophoblast cells of the mammalian blastocyst [0.03%]
哺乳动物囊胚滋养层细胞上皮连接的动态重塑
Xinjian Doris He,Caroline McCaffrey,Kimberly D Tremblay et al.
Xinjian Doris He et al.
Proper junction organization within the trophectoderm is essential for blastocyst integrity and implantation. Epithelial junctions are well characterized in many somatic cell types with a typical apical-basal arrangement of junction type: t...
Foxg1 regulates the development of microvillous cells in the olfactory epithelium [0.03%]
Foxg1调控嗅上皮微绒毛细胞的发育
Sarah K Christian,Laylah Liwaru,Nusaybah Ibrahim et al.
Sarah K Christian et al.
Foxg1 is a transcription factor that plays important roles in the development of the nervous and sensory systems. In the olfactory epithelium, it is known that Foxg1 is necessary for the development of subsets of olfactory sensory neurons, ...
Differences in Cellular mechanics and ECM dynamics shape differential development of wing and haltere in Drosophila [0.03%]
细胞力学和基质动力学的差异塑造了果蝇翅膀和平衡棒的不同发育过程
C Dilsha,Salima Shiju,Neel Ajay Shah et al.
C Dilsha et al.
Diverse organ shapes and sizes arise from the complex interplay between cellular properties, mechanical forces, and gene regulation. Drosophila wing- a flat structure and the globular haltere are two homologous flight appendages emerging fr...
The dynamic landscape of alternative 3' UTR during mammalian preimplantation development [0.03%]
哺乳动物植入前发育期间替代3'UTR的动态景观
Yu Zhang,Anqi Li,Jieyu Wu et al.
Yu Zhang et al.
Alternative polyadenylation (APA) generates mRNA isoforms with distinct 3' UTR lengths, yet its role in mammalian preimplantation development remains largely unexplored. Here, we systematically delineated single-cell 3' UTR APA dynamics in ...
A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development [0.03%]
颅面发育过程中调控Alx1基因表达和功能的一个关键的Twist1调节的远端增强子元件
Yilun Huang,Paul P R Iyyanar,Jingyue Xu et al.
Yilun Huang et al.
Disruption of ALX1 causes frontonasal dysplasia syndrome-3, characterized by extreme microphthalmia, severe midfacial hypoplasia, and orofacial clefting. Recent studies have revealed critical tissue-specific roles of ALX1 in patterning both...
Chick gonad explant electroporation reveals enhancers for testes determining factor, DMRT1 [0.03%]
鸡生殖腺电穿孔实验揭示了性别决定基因DMRT1的增强子元件
Zane Oberholzer,Güneş Taylor,Dorit Hockman et al.
Zane Oberholzer et al.
Enhancers are key regulatory elements that coordinate precise spatio-temporal gene expression during embryonic development. In this study, we used the chick to investigate the regulatory landscape of the highly conserved transcription facto...
Danielle J Gardon,Che-Jui Liu,Natalia A Veniaminova et al.
Danielle J Gardon et al.
Meibomian glands (MGs) in the eyelid secrete lipids that stabilize the tear film and protect the ocular surface. Abnormal MGs are associated with dry eye disease (DED), one of the most common ophthalmological disorders, but the molecular al...