A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development
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Disruption of ALX1 causes frontonasal dysplasia syndrome-3, characterized by extreme microphthalmia, severe midfacial hypoplasia, and orofacial clefting. Recent studies have revealed critical tissue-specific roles of ALX1 in patterning both cranial mesoderm an... ...
