Emma Gairin,Stefano Vianello,Billy Moore et al.
Emma Gairin et al.
The development of organisms with complex life cycles relies on precise endocrine coordination to link environmental cues with morphogenetic programs. In teleost fish, thyroid hormones (TH) play a central role in post-embryonic development ...
Cell and Tissue Mechanics in 3-D Organ Morphogenesis: Insights from Drosophila Pupal Retina Development [0.03%]
果蝇幼虫视网膜发育中的三维器官形态发生：细胞和组织力学的见解
Jacob R Decker,Irmak Altinok,Ilaria Rebay
Jacob R Decker
Morphogenesis requires dynamic changes in cell and tissue mechanics. Because organs are complex multi-cellular structures that develop slowly, understanding how they acquire their unique 3-D forms requires in vivo experimental systems that ...
An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish [0.03%]
用于激活斑马鱼FGF，BMP和Nodal信号的光遗传学工具包
Leanne E Iannucci,Velanganni Selvaraj Maria Thomas,William K Anderson et al.
Leanne E Iannucci et al.
Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in basic and translational research. Here, ...
TGFβ signaling is required during human and chick Neural Crest formation [0.03%]
TGFβ信号在人和鸡神经 crest形成过程中是必需的
Gustavo A Gomez,Bhaval Parmar,Man Wong et al.
Gustavo A Gomez et al.
Neural crest (NC) cells are multipotent cells unique to vertebrates that arise early in development, at the edge of the neural plate, and subsequently undergo an epithelial to mesenchymal transition, migrate throughout the body, and differe...
Pre-fertilization egg coat dynamics in Phallusia philippinensis (Tunicata, Ascidiacea) [0.03%]
菲律宾菲氏四膜虫受精前卵被囊动态变化（尾触手亚门，樽海鞘目）
Kana Hanazaki,Noburu Sensui,Keita Kinjo et al.
Kana Hanazaki et al.
In externally fertilizing species such as ascidians, gametes are released into the surrounding seawater, which makes the fertilization process highly sensitive to environmental conditions. In the ascidian Phallusia philippinensis, the ovidu...
Non-neural crest lineage contributions to the enteric nervous system: Moving a 50 year conclusion [0.03%]
迁移到肠神经系统中的非神经嵴细胞系成分：重新审视半个世纪前的结论
Henry M Sucov,Takako Makita
Henry M Sucov
It is considered an established fact that the entirety of the autonomic nervous system, including the enteric nervous system (ENS), is derived from neural crest. This conclusion is based on classical quail-chick grafting studies conducted b...
Fibroblast Growth Factor 8 Regulates Early Meckel's Cartilage Development via ERK signaling in a Stage- and Dose-Dependent Manner [0.03%]
成纤维细胞生长因子8通过ERK信号在特定阶段和剂量依赖型调控梅克尔软骨早期发生发育
He Qi,Fumie Terao,Diyaa Al Akel et al.
He Qi et al.
Precise spatiotemporal regulation of epithelial-mesenchymal interactions is fundamental to craniofacial morphogenesis. Fibroblast Growth Factor 8 (FGF8) is a pivotal signaling molecule in early mandibular development; however, its stage-spe...
Role of zygotic arrest genes in female meiosis and early embryonic development [0.03%]
合子基因在卵母细胞减数分裂和早期胚胎发育中的作用研究
Srija Sadhukhan,Kousik Pramanick
Srija Sadhukhan
Zygotic arrest genes play an indispensable role in regulating the critical transition from maternal to zygotic control during early embryonic development, commonly referred to as zygotic genome activation (ZGA). These genes orchestrate fund...
Stage-dependent redistribution of protein-protein interaction propensity in canonical Wnt/β-catenin signaling [0.03%]
经典Wnt/β-连环蛋白信号通路中蛋白质相互作用倾向的阶段依赖性再分布
Mishel Abdullah,K Jayadevan,Amalkrishnan Therayil et al.
Mishel Abdullah et al.
Embryonic development relies on precise temporal regulation of signaling pathways, yet most computational analyses of protein-protein interactions treat signaling events as static and time-invariant. Here, we present a time-resolved, ensemb...