Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish [0.03%]
斑马鱼 epicardium 中的 Tcf21 促进心肌细胞去分化和心脏再生
Miglė Kalvaitytė-Repečkė,Sofija Gabrilavičiūtė,Kotryna Kvederavičiūtė et al.
Miglė Kalvaitytė-Repečkė et al.
Unlike mammals, zebrafish (Danio rerio) are able to regenerate their hearts after injury, making them an excellent model organism for studying the molecular mechanisms underlying heart regeneration. Epicardium, the outermost layer of the he...
Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids [0.03%]
基于电转染的基因递送及人源视网膜类器官的整体成像技术
Keevon Flohr,Michael Janeček,Lingyun Wang et al.
Keevon Flohr et al.
Human retinal organoids (hRetOrg) derived from human induced pluripotent stem cells (hiPSCs) have emerged as powerful in vitro systems for studying retinal development, modeling retinal diseases, and evaluating therapeutic strategies. Howev...
PRDM paralogs are required for Meckel's cartilage formation during mandibular bone development [0.03%]
PRDM旁系同源蛋白在下颌骨发育过程中梅克尔软骨形成中是必需的
Qootsvenma Denipah-Cook,Bryanna V Saxton,Kristin B Artinger et al.
Qootsvenma Denipah-Cook et al.
Mandibular bone development depends on the formation of a cartilaginous anlage Meckel's cartilage derived from neural crest cells (NCC) and intramembranous ossification or direct differentiation of NCCs toward osteoblasts. Wnt/β-catenin si...
Genetic background influences the extent and severity of cilia-related congenital anomalies in Ift56/Ttc26 mutant mice [0.03%]
遗传背景影响Ift56/Ttc26突变小鼠相关纤毛先天异常的范围和严重程度
Daisy Xin,Mycah Sewell,Elli Emmanouil et al.
Daisy Xin et al.
Multiple congenital anomalies have been linked to defects in the formation or function of a small cellular organelle called the cilium. The severity of cilia-related syndromes (ciliopathies) ranges from viable with fertility defects to embr...
Challenges and Opportunities for Understanding the Genetic Causes of Congenital Anomalies [0.03%]
探究先天性异常遗传病因的挑战与机遇
Janina Kueper,Ivan Moskowitz,Rolf Stottmann et al.
Janina Kueper et al.
Reprogramming our fate: a postdoctoral reflection on current challenges and prospects for developmental biology [0.03%]
重编命运：一名博士后研究员对发育生物学现状及前景的思考
Ben Dillon Cox,Hailong Yang,Joshua Moore et al.
Ben Dillon Cox et al.
Developmental biology stands at a crossroads. While some have suggested the field is in decline, we, early-career developmental biologists, see an era of renewal driven by conceptual expansion, technical innovation, and cross-disciplinary i...
Cranial neural crest shortage leads to extensive craniofacial anomalies in mice mutant for the NR2F1/2 nuclear receptors [0.03%]
NR2F1/2核受体突变小鼠颅神经嵴细胞不足引起广泛的颅面缺陷
David Paulding,Simon J Y Han,Jonathan Timmons et al.
David Paulding et al.
Nuclear receptors are iteratively deployed during neural crest development, from pre-induction through differentiation stages. NR2F1 and NR2F2 in particular have been proposed as broad regulators of early neural crest gene expression in mam...
A serendipitous convergence- Insights on extracellular matrix proteoglycans and their proteolysis in ensuring successful mammalian birth [0.03%]
一种意外的汇合——关于细胞外基质蛋白聚糖及其蛋白水解作用以确保成功的哺乳动物分娩的见解
Suneel S Apte
Suneel S Apte
Tissues comprise not only cells, but also extracellular matrix (ECM), which is assembled from some of the most abundant molecules in animals. ECM composition and organization underlie the tissue architecture of most organs by design and is ...
Optogenetic activation of primary sensory neurons induces metamorphosis in Ciona [0.03%]
光遗传学激活初级感觉神经元可诱导海鞘变态发育
Nozomu M Totsuka,Kohji Hotta
Nozomu M Totsuka
Metamorphosis is a key event in development that is conserved in many marine organisms. Ciona intestinalis type A induces metamorphosis through the settlement of papillae onto the substrate. The papilla consists of collocytes (CCs), primary...
Environmental yin-yang: how external cues are processed at the level of cells and at the level of an organism [0.03%]
环境阴阳：如何在外在因素作用下细胞和个体处理相关信息
Zainab Afzal,Deepak Kumar
Zainab Afzal
From inception, the environment plays a critical role, first in the development of an organism, and later, as adults, in how an organism through homeostatic processes may undergo changes in response to external exposures or insults. Exposur...