CREBBP stabilizes GNG3 protein through acetylation, thereby activating the NF-κB pathway and exacerbating airway inflammation in allergic rhinitis [0.03%]
CREBBP通过乙酰化稳定GNG3蛋白，激活NF-κB通路并加重过敏性鼻炎气道炎症
Meng Chen,Zhihui Yuan
Meng Chen
Objective: Allergic rhinitis (AR), an allergen-driven chronic inflammatory disorder of nasal mucosa, is characterized by airway inflammation as its cardinal pathological manifestation. While acetylation is known to regula...
Jennifer Krznarich,Tessa Schumann,James Bjork et al.
Jennifer Krznarich et al.
Objective: The increasing frequency and intensity of wildfires pose significant environmental and public health risks. While existing research has highlighted the effects of wildfire smoke exposure on chronic diseases, th...
Saikosaponin D ameliorates sepsis-induced acute lung injury by maintaining alveolar epithelial barrier integrity and inhibiting ferroptosis via Nrf2/HO-1 pathway [0.03%]
槐果碱D通过Nrf2/HO-1信号通路维持肺泡上皮屏障的完整性并抑制铁死亡从而改善脓毒症诱导的急性肺损伤
Lijie Song,Yanyan Tao,Guoyu Lu et al.
Lijie Song et al.
Background: Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum chinensis, has many pharmacological properties. The goal of our study is to assess the roles and mechanisms of SSD in septic acute lung inj...
The Fli1 transcription factor aggravates lipopolysaccharide-induced human pulmonary microvascular endothelial cell dysfunction by regulating CXCL2 promoter [0.03%]
转录因子Fli1通过调控CXCL2启动子加剧脂多糖诱导的人肺微血管内皮细胞功能障碍
Zhou Zheng,Lei Liu,Hao Zhang et al.
Zhou Zheng et al.
Objective: Pulmonary microvascular endothelial cell (PMEC) injury is a hallmark of septic acute lung injury (ALI). Elevation of chemokine C-X-C motif ligand 2 (CXCL2) is associated with inflammatory response in various di...
Correction [0.03%]
改正之法
Published Erratum
Inhalation toxicology. 2025 Jun 15:1. DOI:10.1080/08958378.2025.2514900 2025
Identification of functional roles and therapeutic targets of the STAT pathway in PM2.5-induced allergic rhinitis [0.03%]
PM2.5诱导的过敏性鼻炎中STAT通路的功能角色及治疗靶点识别
ChiHang Zhang,JianShu Guo,Lei Lei et al.
ChiHang Zhang et al.
Background: Increasing evidence suggests that exposure to fine particulate matter (PM2.5) is associated with an elevated risk of respiratory diseases. However, the precise mechanisms by which PM2.5 influences inflammatory...
TMEM175 activity in BK-deficient macrophages maintains lysosomal function and mediates silica-induced inflammatory response in macrophages [0.03%]
TMEM175活性可弥补巨噬细胞中两性霉素B缺陷并维持溶酶体功能以及介导二氧化硅诱导的巨噬细胞炎症反应
Rebekah L Kendall,Britten Postma,Andrij Holian
Rebekah L Kendall
Objective: Lysosomal ion channel function in macrophages contributes to the development of silica-induced inflammation. Recent studies have shown that blocking K+ entry into the lysosome via the BK channel reduces silica-induced damage and ...
Maureen Meister,Xiaojia He,Alexandra Noël et al.
Maureen Meister et al.
Electronic nicotine delivery systems (ENDS) arrived on the U.S. market in 2007 and rapidly grew in popularity as a harm reduction tool for traditional cigarette users. While initially marketed as a healthier alternative to combustible cigar...
The association between smoking profile, leukocyte count, and inflammatory indices in males: a cross-sectional analysis of the TABARI cohort study at enrollment phase [0.03%]
吸烟与白细胞计数及炎症标志物的相关性分析——基于TABARI队列研究基线调查数据的横断面研究
Erfan Ghadirzadeh,Mahmood Moosazadeh,Motahareh Kheradmand et al.
Erfan Ghadirzadeh et al.
Background: Cigarette smoking stands as a prominent contributor to global mortality rates, and its impact spans both immediate and long-term effects on hematological parameters; however, in addition to controversial resul...
Association of Glutathione S-transferase gene polymorphism with coronary artery disease (CAD) in North Indian population (Jammu and Kashmir): evidence from a case-control study and an updated meta-analysis [0.03%]
北印度人（杰姆鲁和克什米尔）中谷胱甘肽S转移酶基因多态性与冠状动脉疾病相关性的病例对照研究及荟萃分析最新证据
Jyotdeep K Raina,Ravi Sharma,Naveen Kumar et al.
Jyotdeep K Raina et al.
Background: Chemicals released during cigarette smoking disrupt the structure, function and physiological capacity of the cardiovascular system. Detoxification of these harmful chemicals is done by Glutathione S-transfera...