The beginning of ENDS (electronic nicotine delivery systems): origins, trends, and regulatory considerations [0.03%]
ENDS（电子尼古丁递送系统）的开始：起源、趋势和监管问题考虑
Shaligram Sharma,Maureen Meister,Scott Weaver et al.
Shaligram Sharma et al.
Electronic nicotine delivery systems (ENDS), commonly known as e-cigarettes, are battery-operated devices that produce aerosols by vaporizing e-liquids, which typically contain propylene glycol and/or vegetable glycerin, nicotine, and flavo...
Inclusion of particle dispersion in a rat particle deposition: model improvement and validation [0.03%]
颗粒分散在大鼠颗粒沉积模型中的包含：模型改进和验证
Bahman Asgharian,Owen T Price,Kaisen Lin et al.
Bahman Asgharian et al.
Deterministic models have been developed for the predictions of the deposited dose to the respiratory tract from inhalation of airborne materials. The complexity of the lung geometry, ventilation mechanics, and transport processes have requ...
Inhalation dosimetry and dose-response analysis of diacetyl, 2, 3-pentanedione, and acetoin using respiratory tract vapor uptake models [0.03%]
使用呼吸系统蒸汽摄取模型对二乙酰、23-戊二酮和乙偶姻的吸入剂量和剂量反应分析
Jeffry D Schroeter,Julia S Kimbell,Bahman Asgharian et al.
Jeffry D Schroeter et al.
Objective: The objectives are to develop inhalation dosimetry models of the flavoring agents diacetyl, 2, 3-pentanedione, and acetoin to predict uptake throughout the rat and human respiratory tracts and use the results w...
A mechanistic review-regulation of silica-induced pulmonary inflammation by IL-10 and exacerbation by Type I IFN [0.03%]
机制审查 - IL-10对硅诱导的肺部炎症的调节及I型IFN的加剧作用
Hajime Kawasaki
Hajime Kawasaki
Occupational exposure to crystalline silica (CS) is known to induce silicosis, a chronic lung disease characterized by the formation of granulomas and severe lung fibrosis. Specifically, individuals exposed to low doses of CS may develop si...
A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis [0.03%]
关注粒子：微塑料致肺损伤和肺纤维化的潜在机制探究与假说
Rohit Kumar Gautam,Laltanpuia,Nishant Singh et al.
Rohit Kumar Gautam et al.
Purpose: In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic an...
Meta-analysis of the association between low concentration PM2.5 and cardiovascular mortality in the United States and Canada [0.03%]
美国和加拿大关于低浓度PM2.5与心血管死亡率关联的荟萃分析研究
Chloe S Chung,Giffe T Johnson,Annette C Rohr
Chloe S Chung
Objectives: The adverse effects of fine particulate matter (PM2.5), including cardiovascular outcomes, are well established. This review and meta-analysis investigates the association between long-term exposure to low con...
W Kyle Mandler,Walter G McKinney,Mark Jackson et al.
W Kyle Mandler et al.
Purpose: Pulmonary exposure to emissions from manipulating solid surface composite (SSC) materials has been associated with adverse health effects in humans and laboratory animals. Previous in vitro and in vivo investigations of SSC toxicit...
Urinary oxidative stress biomarkers in nephrotoxicity induced by PM2.5 in a rat model [0.03%]
PM₂.５肾毒性大鼠模型尿液氧化应激生物标志物的研究
Jessica Baldriche-Acosta,Marisela Uribe-Ramírez,Juana Narváez-Morales et al.
Jessica Baldriche-Acosta et al.
Objective: The present study evaluated urinary oxidative stress (OxS) biomarkers to explain the extrapulmonary effect of renal function decline due to subchronic inhalation exposure to particles smaller than 2.5 μm, as w...
Temporal evaluation of lung injury following chlorine Inhalation in a ventilated pig model [0.03%]
通气猪模型中氯吸入后肺损伤的时长评价
Matthew Neal,Jill Harvilchuck,David Pressburger et al.
Matthew Neal et al.
Objective: Chlorine (Cl2) is a widely used industrial chemical and toxic human exposures have occurred from Cl2 releases. No approved medical countermeasures (MCMs) exist for Cl2-induced lung injuries. The objective of th...
GRP78 mediates mitochondrial fusion and fission in cigarette smoke-induced inflammatory responses in airway epithelial cells [0.03%]
COPD小气道上皮细胞GRP78介导线粒体融合与分裂的调控作用
Yong Wang,Ya-Jing Li,Chen-Chen Li et al.
Yong Wang et al.
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, with cigarette smoke being a major contributor to epithelial injury. Recent studies have shown that abnormal mito...