Exposure to electronic cigarette aerosols triggers alterations in genomic DNA methylation that impacts cancer pathways in mice [0.03%]
电子烟气溶胶会引发小鼠基因组DNA甲基化改变并影响癌症通路
Christina Awada,Catherine B Klein,Terry Gordon et al.
Christina Awada et al.
Objective: The aim of this laboratory study was to characterize the effects of sub-chronic electronic cigarette (E-cig) aerosol exposures on genome-wide DNA methylation in mice to begin to elucidate the pathophysiology of...
Establishing an air-liquid interface system for exposure of mouse laryngeal epithelial cells to cigarette smoke [0.03%]
小鼠声门上区黏膜空气液界面系统的建立及烟雾暴露损伤机制研究
Akari Kimura,Amirbahador Golchin,Meena Easwaran et al.
Akari Kimura et al.
Objective: The laryngeal epithelium is one of the first lines of defense against inhaled insults, including cigarette smoke (CS). However, a lack of suitable in vitro models has limited mechanistic studies of laryngeal ep...
Inhibiting the Nrf2/HO-1 signaling cascade weakens the pro-inflammatory response induced by gasoline engine exhaust in lung epithelial cells following air-liquid interface exposure [0.03%]
抑制Nrf2/HO-1信号通路减弱汽油发动机尾气上皮细胞空气-液体界面暴露诱导的炎性反应
Ying Qu,Guoliang Li,Tao Yu et al.
Ying Qu et al.
Objective: This study aimed to investigate the role of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling cascade in the inflammatory responses induced by whole gasoline engine exhaust ...
Risk stratification for myocardial injury and mortality in acute carbon monoxide poisoning: a multivariable predictive model [0.03%]
急性一氧化碳中毒心肌损伤和死亡风险分层的多变量预测模型
Yongai Ling,Changsheng Ye,Xianwei Xiong et al.
Yongai Ling et al.
Background: Myocardial injury following carbon monoxide (CO) poisoning is associated with increased mortality, yet early predictors remain poorly characterized. This study aimed to develop predictive models for early risk stratification usi...
4-OI improves mitochondria-associated endoplasmic reticulum membrane dysfunction by regulating MFN2 through Nrf2 transcription and alleviates airway inflammation in asthma exposed to PM2.5 early in life [0.03%]
4-OI通过Nrf2转录调节MFN2来改善哮喘患者在生命早期接触PM₂.₅引起的线粒体相关内质网膜功能障碍及气道炎症
Jiaxin Xu,Lei Wang,Rui Zhou et al.
Jiaxin Xu et al.
Background: Asthma is a disease that still lacks effective preventive measures with distinctive pathologicfeatures, particularly inflammation, oxidative stress, apoptosis and endoplasmic reticulum (ER) stress. 4-Octyl ita...
PET/CT imaging-based quantification of respiratory tract deposition of small- and large-particle aerosols versus intranasal bolus in rodents [0.03%]
基于PET/CT影像的呼吸道给药沉积定量方法及鼻腔给药的比较研究小鼠和大鼠中小颗粒气溶胶与大颗粒气溶胶
Jeremy A Boydston,Hee-Jeong Yang,Steve Mazur et al.
Jeremy A Boydston et al.
Objectives: The size of airborne particles may influence where they deposit in the respiratory tract, the infectious dose, and disease progression. Intranasal bolus administration is often used as a substitute for aerosol...
An experimental validation of computational fluid dynamics for airflow in a subject-specific normal human nasal model using a precise 3D-printed replica [0.03%]
使用精密3D打印复制品对人类特异性正常鼻模型气流的计算流体动力学进行实验验证
Yin Cheng,Yajing Zhu,Shenglin Yan et al.
Yin Cheng et al.
Background: Computational fluid dynamics (CFD) is widely used for studying nasal airflow but is rarely rigorously validated against experimental data. This study aimed to validate a subject-specific CFD model by comparing...
Rat strain differences in bronchoalveolar lavage fluid and minimal association with histopathology findings [0.03%]
BALF的各品系小鼠差异及与组织学评分的关联性分析
Nataliia Kovalchuk,Christopher Smith,Emily Hackshaw
Nataliia Kovalchuk
Background: Six years since the revised Test Guidelines 412 and 413 (TG412 and TG413) were issued, there are sufficient data to evaluate the relationship between bronchoalveolar lavage (BAL) cytology and biomarkers with h...
Long-term cardiovascular and respiratory health effects of e-cigarette use: a narrative review of emerging evidence [0.03%]
电子烟使用的长期心血管和呼吸系统健康影响：新兴证据的叙述性综述
Rachael Obeng,Oluwabunmi Dada,Emmanuel Odame et al.
Rachael Obeng et al.
Background: The rapid rise in e-cigarette use has generated increasing public health concern regarding its long-term effects on the cardiopulmonary system. Although e-cigarettes are often marketed as a safer alternative t...
Numerical investigation of the effects of respiratory modes and ablation lesions on airflow and particle deposition in a pulmonary acinar model [0.03%]
基于肺泡模型的呼吸模式及射频消融对气流和颗粒沉积影响的数值研究
Qian Tang,Xin Zheng,Jia Lu et al.
Qian Tang et al.
Understanding particle deposition patterns in the pulmonary acinus is essential for early intervention and treatment in acinar diseases. This study numerically investigated the effects of respiratory modes and emphysematous alveolar wall ab...