Effect of L-theanine on the hippocampus, cerebral cortex and cerebellum of doxorubicin-treated rats [0.03%]
L-茶氨酸对多柔比星致大鼠海马、大脑皮质和小脑的影响
Birgül Kural,Sevil Kör,Meltem Arıkan Malkoç et al.
Birgül Kural et al.
Neurotoxicity is an important side-effect of many chemotherapeutic agents, including doxorubicin (DXR). L-Theanine (LT) is a non-protein amino acid with a variety of beneficial health effects, involving anti-inflammatory, antimicrobial, ant...
Optimization of the process and kinetic mechanism of ginsenoside Rb1 conversion by β-glucanase [0.03%]
β-葡聚糖酶催化人参皂苷Rb1转化的工艺及动力学机制优化研究
Yu Xie,Yue Shi,Yinan Hong et al.
Yu Xie et al.
Ginsenoside F2 has multiple biological effects, such as cardiovascular protection, antioxidant. However, ginsenoside F2 is extremely low in natural ginseng plants; it can be obtained by deglycosylation of ginsenoside Rb1. In this paper, hig...
Curcumin alleviates non-alcoholic fatty liver disease by modulating inflammation, barrier function, and gut microbiota [0.03%]
姜黄素通过调节炎症、屏障功能和肠道微生物群来缓解非酒精性脂肪肝病
Hou Hui,Abulizi Guzailiayi,He Sirui et al.
Hou Hui et al.
Objectives: Non-alcoholic fatty liver disease (NAFLD) ranks as the most common chronic liver disease with limited effective therapeutic strategies. Curcumin, an active ingredient extracted from the rhizomes of curcuma lon...
Leveraging genomic conservation in emerging SARS-CoV-2 variants for precision diagnostics, vaccines, and RNAi therapeutics [0.03%]
利用新出现的SARS-CoV-2变异体的基因组保守性进行精准诊断、疫苗和RNA干扰治疗
Cuneyd Parlayan,Khandakar A S M Saadat,Muhammetnur Tekayev et al.
Cuneyd Parlayan et al.
Background: The ongoing evolution of SARS-CoV-2 has led to the emergence of numerous variants, challenging the efficacy of existing diagnostics, vaccines, and therapeutics. Despite this genomic variability, several region...
l-Arginine in diabetic cardiomyopathy: Mechanistic insights into RAGE-NF-κB-SREBP1 signaling [0.03%]
L-精氨酸在糖尿病心肌病中的作用：RAGE-NF-κB-SREBP1信号通路的机制研究
Muskan R Thakur,Rashmi S Tupe
Muskan R Thakur
In diabetes, glycation exacerbates low-grade inflammation and lipotoxicity, driving the development and progression of diabetic cardiomyopathy (DCM). l-Arginine (L-Arg) supplementation is crucial in the management of diabetes and cardiovasc...
Piceatannol affects fatty acid mobilization during isoproterenol-induced lipolysis in pig precision-cut adipose tissue slices [0.03%]
白杨叶素影响异丙肾上腺素诱导的猪精确切割脂肪组织片中脂肪酸动员作用
Apolline Goudmaeker,Aurélien Warnant,Thomas Baily et al.
Apolline Goudmaeker et al.
Piceatannol, a stilbene structurally close to resveratrol, was previously shown to reduce lipolysis in mouse adipocytes both in vitro and in vivo. Here, we investigated the effects of both resveratrol and piceatannol on pig precision-cut ad...
Exercise impact on IRE1α signaling: Novel insights into Alzheimer's disease prevention and treatment [0.03%]
运动对IRE1α信号传导的影响：阿尔茨海默病预防和治疗的新见解
Tu Haixia,Xu Bo
Tu Haixia
Endoplasmic reticulum stress (ERS) and its downstream signaling play a central role in neuroinflammation in Alzheimer's disease (AD). Among them, IRE1α, as a key sensor of ER stress, is a pivotal molecule connecting stress to inflammation....
The role of the CTBP2 mediated glycolytic pathway in nasopharyngeal carcinoma metastasis [0.03%]
CTBP2介导的糖酵解途径在鼻咽癌转移中的作用
Yiling Lin,Kunfei Yu,Xuewu Tian et al.
Yiling Lin et al.
Nasopharyngeal carcinoma (NPC) progression is closely linked to aerobic glycolysis. C-terminal binding protein 2 (CTBP2), recognized as a glycolytic sensor, supporting the metabolic and biosynthetic needs of cancer cells and driving tumor p...
HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress [0.03%]
HER3在内质网应激下增强ATF4诱导和乳腺癌细胞存活中的作用
Miku Otsuka,Yuka Okamoto,Akiko Hasebe et al.
Miku Otsuka et al.
Oncogenic signaling and stress response pathways interact to drive tumorigenesis and therapy resistance. However, little is known about such interactions for HER3, a member of the HER/ErbB receptor family that is aberrantly expressed in man...
Plant-derived efflux pump inhibitors potentiate Chlorin e6-based antimicrobial photodynamic therapy against Bacillus cereus and Escherichia coli [0.03%]
植物来源的外排泵抑制剂可增强基于叶绿素e6的针对蜡样芽孢杆菌和大肠杆菌的光动力抗菌疗法
Aleksandra Talarczyk,Agata Kublicka,Anna Matczuk et al.
Aleksandra Talarczyk et al.
ANTIMICROBIAL RESISTANCE: especially via efflux pump-mediated multidrug resistance is a major factor limiting antibacterial therapy efficacy. Antimicrobial photodynamic therapy (aPDT) is a non-antibiotic strategy that overcomes resistance t...