From ROS to Cuproptosis: The molecular evolution of copper nanotherapeutics [0.03%]
从ROS到Cuproptosis：铜基纳米治疗剂的分子进化历程
Egor A Turovsky
Egor A Turovsky
The renewed interest in copper-based materials for biomedical applications has been catalyzed by advances in nanotechnology, shifting the paradigm from empirical antimicrobial therapies toward multifunctional nanoplatforms capable of target...
Genomic language models (gLMs): Emerging applications, challenges, and future directions in computational genomics [0.03%]
基因组语言模型（gLM）：计算基因组学中新兴应用、挑战和未来方向
Mahinaz A Mashhour,Manal Abdel Wahed,Mai S Mabrouk
Mahinaz A Mashhour
Genomic language models (gLMs) are rapidly becoming important tools for learning biological information directly from sequence data. By adapting concepts from natural language processing, these models aim to capture contextual dependencies,...
Ttyh3 ameliorates myocardial ischemia-reperfusion injury by activating Akt1 signaling to suppress apoptosis [0.03%]
TTyh3通过激活Akt1信号通路来抑制心肌缺血再灌注损伤中的凋亡作用
Yanyan Xu,Ruoyun Lang,Jianpei Xian et al.
Yanyan Xu et al.
Myocardial ischemia-reperfusion injury (MIRI) poses significant challenges in cardiovascular therapeutics, with the molecular mechanisms underlying cardiomyocyte apoptosis remaining incompletely understood. This study identifies Ttyh3 as a ...
The mitochondrial DNA signal in rheumatoid arthritis: From metabolic victim to inflammatory driver [0.03%]
风湿性关节炎中的线粒体DNA信号：从代谢受害者到炎症驱动者
Ruoyi Zhang,Zhijie Song,Qimeng Xin et al.
Ruoyi Zhang et al.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by sustained immune activation and profound metabolic dysregulation. Accumulating evidence indicates that mitochondrial DNA (mtDNA) plays an active role in linking mi...
RepID orchestrates CDH1 and CTNNB1 homeostasis to regulate metastatic potential in small cell lung cancer [0.03%]
RepID调节CDH1和CTNNB1的稳态以调控小细胞肺癌的转移潜能
Dong-Kyu Kim,Jae-Hyun Jo,Jong-Uk Park et al.
Dong-Kyu Kim et al.
Small cell lung cancer (SCLC) is defined by its aggressive progression and early systemic dissemination, yet the molecular drivers that orchestrate its metastatic potential remain elusive. Here, we identify the replication initiation determ...
A deep intronic CPS1 variant causing pseudo-exon activation identified in an adult with molecularly unconfirmed urea cycle disorder [0.03%]
在一名分子未确诊的尿素循环障碍成人患者中鉴定到一个深入内含子的CPS1变异导致假 exon激活
Miki Honto,Eri Imagawa,Hiroshi Mochizuki et al.
Miki Honto et al.
Background: Diagnosing proximal urea cycle disorders (UCDs) remains challenging due to the lack of definitive diagnostic biochemical markers, which can lead to delayed or missed diagnosis. Although molecular genetic testi...
Computational design and evaluation of Factor Xa inhibitory peptides derived from the Tamarind Kunitz inhibitor reactive loop [0.03%]
基于番木瓜凝乳蛋白酶抑制剂反应环衍生的计算设计和评估因子Xa抑制肽
Ashok Soota,Divya Aggarwal,Shalja Verma et al.
Ashok Soota et al.
Blood coagulation is a crucial process, and its dysregulation can lead to life-threatening conditions. Factor Xa (FXA) is a well-established therapeutic target for the management of vascular diseases, as it acts as a converging point of bot...
Exploring Methyl-4-hydroxybenzoate-associated CDK1 dysregulation in breast cancer: A multi-omics investigation combining network toxicology, transcriptomics, and molecular dynamics [0.03%]
基于网络毒理学、转录组和分子动力学的多组学调查发现对羟基苯甲酸甲酯致乳腺癌的作用机制：以CDK1异常调控为例
Yang Wang,Jing Li,Zhen Liu et al.
Yang Wang et al.
Breast cancer remains a major global health burden, and environmental endocrine-disrupting chemicals may contribute to breast-cancer-related phenotypes. Methyl-4-hydroxybenzoate (MEP; methylparaben) is a widely used preservative with report...
Ion channel TRPML2 (MCOLN2) promotes ovarian cancer metastasis and chemoresistance [0.03%]
TRPML2(MCOLN2)离子通道促进卵巢癌转移和耐药性
Shizhang Yang,Zhenchuan Lei,Xiaoqiang Yao et al.
Shizhang Yang et al.
Background: Ovarian cancer, with metastasis and chemoresistance being the major obstacles to successful treatment, is a leading cause of death among gynecological malignancies. Identifying new molecular targets and unders...
Cooperative IFN-γ and TLR9 signaling reprogram tumor-associated macrophages to enhance antitumor immunity in melanoma [0.03%]
IFN-γ和TLR9信号合作重编肿瘤相关巨噬细胞以增强黑色素瘤中的抗肿瘤免疫反应
Toan Van Le,Ruslan Deviatiiarov,Yamano Tomoyoshi et al.
Toan Van Le et al.
Tumor-associated macrophages (TAMs) often adopt immunosuppressive phenotypes that promote tumor progression and limit the efficacy of immunotherapy. Although Toll-like receptor 9 (TLR9) agonists and interferon-γ (IFN-γ) possess immunostim...