Melatonin attenuates ovarian injury concomitantly with alterations in SMAD7 protein expression and related microRNAs in a rat model of adnexal torsion-detorsion [0.03%]
褪黑素通过调节SMAD7蛋白表达及相关的微小RNA减轻卵巢扭转再灌注损伤
Feyyaz Ozel,Tansel Sapmaz,Sibel Kuras et al.
Feyyaz Ozel et al.
This study aimed to investigate the histopathological and molecular effects of melatonin on ovarian follicle reserve, SMAD7 immunolocalization, and SMAD7-related miRNAs (miR-182, miR-21, miR-92) in a rat model of adnexal torsion-detorsion (...
Exploring the therapeutic potential of NCX1 in hematological cancers; integration of molecular docking, bioinformatics approaches, and experimental validation [0.03%]
基于分子对接、生物信息学方法及实验验证探索NCX1在血液系统肿瘤中治疗潜力
Sema Misir,Serap Ozer Yaman,Nina Petrović et al.
Sema Misir et al.
Hematological malignancies are highly heterogeneous diseases characterized by dysregulated signaling pathways and limited durable therapeutic responses. Calcium homeostasis has emerged as a critical regulator of cancer cell fate, yet the ro...
Cytological and transcriptomic responses of WI-38 human lung fibroblasts to plant-exposed metal nanoparticle residues [0.03%]
植物接触金属纳米颗粒残留物对WI-38人肺成纤维细胞的细胞学和转录组响应
Maysa A Mobasher,Shaza D Abd El-Moneim,Yosur Gamal Fiteha
Maysa A Mobasher
Metal-based nanoparticles are increasingly encountered in human exposure scenarios, yet the relationship between residue-level exposure and cellular hazard remains unclear. In this study, iron (Fe), copper (Cu), and silver (Ag) nanoparticle...
Filamin A inhibits neural stem cell self-renew by downregulating rDNA transcription [0.03%]
Filamin A通过下调rDNA转录抑制神经干细胞自我更新
Zihui Wu,Xiangyu Zhou,Xiaoye Song et al.
Zihui Wu et al.
Neural stem cells (NSCs) are the basis of neurogenesis and neural regeneration and are widely used as models for drug test and disease therapy. However, how NSCs self-renewal is modulated is not fully understood. In this study, we show that...
Digoxin inhibits HIF-1α to attenuate inflammation and fibrosis in thyroid eye disease [0.03%]
地高辛通过抑制HIF-1α来减轻甲状腺眼病的炎症和纤维化
Jie Ling,Chengzhen Gong,Huijing Ye et al.
Jie Ling et al.
Background: Thyroid eye disease (TED) is characterized by orbital inflammation and fibrosis, with a hypoxic microenvironment implicated in disease pathogenesis. ...
The protein kinase GCN2 senses the integrity of the multi-tRNA synthetase complex [0.03%]
蛋白质激酶GCN2感应多tRNA合成酶复合物的完整性
Richard Cardoso da Silva,Beatriz A Castilho
Richard Cardoso da Silva
Aminoacyl-tRNA synthetases (ARSs) assemble with ARS-interacting multifunctional proteins (AIMPs) to form the multi-tRNA synthetase complex (MSC), a supramolecular complex proposed to enhance efficiency of tRNA aminoacylation. Here, we show ...
The ALOX5-Mitochondrial oxidative stress link in quercetin-mediated nasal epithelial barrier protection in allergic rhinitis [0.03%]
檞皮素通过ALOX5-线粒体氧化应激介导的鼻粘膜上皮屏障保护作用机制研究（译）
Mengfei Luo,Xinyu Liu,Fusen Peng
Mengfei Luo
Objectives: Allergic rhinitis (AR) is characterized by persistent allergic inflammation and nasal epithelial barrier dysfunction. Quercetin is a candidate bioactive compound of Hedyotis Diffusae Herba, but its epithelial ...
An orthogonal mammalian gene circuit for selective sensing of taurine-conjugated bile acids [0.03%]
一种正交哺乳动物基因线路选择性感应牛磺结合胆汁酸
Zhaoping Lu,Yingjun Shi,Naiyun Deng et al.
Zhaoping Lu et al.
Beyond their traditional role as dietary lipid emulsifiers, bile acids (BAs) function as pleiotropic signaling molecules that regulate metabolism, inflammation, and diverse disease processes. Taurine-conjugated bile acids (Tau-BAs) and the ...
Ppif deficiency promotes DEN-induced hepatocarcinogenesis by altering hepatocyte responses to carcinogenic stress [0.03%]
Ppif缺陷通过改变肝细胞对致癌刺激的反应促进二乙基亚硝胺诱导的肝癌发生发展
Hye-Kyung Park,Sung Hu,Hana Song et al.
Hye-Kyung Park et al.
Ppif (Cyclophilin D, CypD) is a key regulator of mitochondrial permeability transition pore (mPTP) opening and plays an important role in maintaining mitochondrial homeostasis by regulating mitochondrial calcium dynamics and redox balance. ...
Developmental toxicity assessment of molybdenum titanium carbide MXene using zebrafish embryo and larvae model [0.03%]
使用斑马鱼胚胎和幼体模型评估二硫化钼的发育毒性
Kadhirmathiyan Velumani,Balamurugan Shanmugaraj
Kadhirmathiyan Velumani
MXenes are two-dimensional (2D) transition metal carbides and nitrides with promising applications in biomedicine, drug delivery, and tissue engineering. However, their information regarding the developmental safety in aquatic organisms rem...