MCAO rat model-guided identification of crucial miRNAs and stroke-related networks via high-throughput sequencing [0.03%]
基于高通量测序的MCAO大鼠模型指导下的卒中相关关键miRNA及网络识别
Jiang Wu,Yuying Yang,Shan Yuan et al.
Jiang Wu et al.
Ischemic stroke is a complex polygenic disorder, in which microRNAs (miRNAs) have been implicated in various physiological and pathological processes. However, the specific regulatory networks and mechanisms involving brain miRNAs in the de...
Elevated miR-145/TLR4/NF-κB signaling correlates with myocardial PANoptosis in septic rats [0.03%]
miR-145/TLR4/NF-κB信号通路活化与脓毒症大鼠心肌PANoptosis相关性研究
Zengfeng Wang,Yansheng Shan,Cang Li et al.
Zengfeng Wang et al.
Background: Sepsis is a life-threatening organ dysfunction driven by dysregulated host responses to infection. While PANoptosis-a coordinated cell death pathway-has emerged as a critical process in inflammatory diseases, ...
Amplitude dependence in extracellular vesicle release from cultured myotubes under vibration stimulation [0.03%]
振动刺激下单肌管细胞培养中外泌体释放的振幅依赖性研究
Qingcheng Guo,Yunfei Fu,Xiaoqi Ma et al.
Qingcheng Guo et al.
Background: Skeletal muscle-derived extracellular vesicles (SkM-EVs) are promising mediators of intercellular communication, yet practical strategies to safely and efficiently enhance their release remain limited. Vibrati...
Unraveling the molecular mechanisms of air pollution-induced lung adenocarcinoma through machine learning, network toxicology, and molecular docking [0.03%]
通过机器学习、网络毒理学和分子对接解析空气污染所致肺腺癌的分子机制
Yang Xu,Bin Yuan,Mingjun Zhang
Yang Xu
Objective: Airborne environmental contaminants are established carcinogens. This investigation elucidates the mechanistic contributions to pulmonary adenocarcinoma (LUAD) pathogenesis. ...
SPP1-CD44 signaling contributes to the mechanisms and therapeutic implications in intervertebral disc degeneration [0.03%]
SPP1-CD44信号通路参与椎间盘退变的作用及治疗意义机制研究
Qiuwei Li,Kaida Bo,Cailiang Shen
Qiuwei Li
Background: Intervertebral disc degeneration (IVDD) is a major pathological cause of chronic back pain and reduced mobility. Among emerging molecular regulators, the SPP1-CD44 axis has attracted growing interest for its c...
Comprehensive pharmacological insights into Glaucocalyxin A: Mechanisms and therapeutic potential [0.03%]
关于绿碱叶素A的全面药理学见解：机制和治疗潜力
Yizhou Zheng,Lin Liu,Lilong Liu et al.
Yizhou Zheng et al.
Glaucocalyxin A (GLA) is an ent-kauranoid diterpenoid isolated from Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara. As a promising compound with significant therapeutic potential, GLA has garnered attention for its diverse rang...
SLC16A3 as a novel therapeutic target for overcoming radioresistance and chemoresistance in lung cancer [0.03%]
SLC16A3作为克服肺癌放疗和化疗抵抗的新治疗靶点
Hye Min Kim,Min Ji Bae,Chang Geun Lee et al.
Hye Min Kim et al.
Radiotherapy and chemotherapy are central components of lung cancer treatment. However, the development of therapeutic resistance significantly limits their efficacy. Here, we identified SLC16A3 as a potential biomarker associated with radi...
Force transmission in an actomyosin cytoskeletal network revealed by particle fluctuation analysis [0.03%]
基于颗粒波动的肌动蛋白肌球蛋白胞质骨架网络力学性质的研究
Masato Ito,Yusuke T Maeda
Masato Ito
Actomyosin cytoskeleton, composed of actin filaments and myosin motor proteins, functions as nanoscale force generators within the cytoskeleton. While they generate contractile forces in the cytosol of living cells, the nature of non-therma...
Progranulin is increased during prodromal pathology in LRRK2 G2019S mice [0.03%]
Lrrk2基因突变小鼠病程前驱期朘蛋白原粒素水平升高
Soung-Hee Moon,Hyun Jin Choi
Soung-Hee Moon
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is a major genetic risk factor for Parkinson's disease (PD). Most studies have shown that this mutation alone is insufficient to induce marked motor impairment or notable dopaminergic...
Quinones as promising agents for managing metabolic syndrome: Therapeutic and toxicological considerations [0.03%]
醌类作为代谢综合征管理的有希望的药物：治疗和毒理学考量
Tamsheel Fatima Roohi,Zahoor Ahmad Parray,Syed Faizan et al.
Tamsheel Fatima Roohi et al.
Metabolic syndrome, characterized by insulin resistance, hypertension, dyslipidemia, and obesity, poses significant global health concerns. Quinones, a class of natural and synthetic compounds containing a fully conjugated cyclic unsaturate...