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The protein kinase GCN2 senses the integrity of the multi-tRNA synthetase complex

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Aminoacyl-tRNA synthetases (ARSs) assemble with ARS-interacting multifunctional proteins (AIMPs) to form the multi-tRNA synthetase complex (MSC), a supramolecular complex proposed to enhance efficiency of tRNA aminoacylation. Here, we show that disassembly of ... ...