A synthetic hydrogel scaffold enhancing stem cell signatures in colorectal cancer cells [0.03%]
一种合成水凝胶支架可增强结直肠癌细胞的干细胞特征
Qiaochu Fu,Cewen Chen,Lei Wang et al.
Qiaochu Fu et al.
Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies worldwide. Strategies to eradicate cancer stem cells (CSCs) are essential for developing more promising therapies against CRC. However, the rarity and heterogeneit...
Inhibition of mitochondrial complex I by rotenone reduces arterial calcification in vitro [0.03%]
鱼藤酮抑制线粒体复合物I减少动脉钙化（体外研究）
Andrea Gorgels,Tabea Köneke,Setareh Karimian et al.
Andrea Gorgels et al.
Aim: Cardiovascular diseases are the leading cause of death worldwide, with arterial calcification being a risk factor, especially in patients with diabetes and kidney disease. Arterial calcification involves hydroxyapati...
β-Carotene induces context-dependent redox remodeling in gastric cancer cells following comparative carotenoid screening: Integrated electronic, membrane, and metabolomic analysis [0.03%]
β-胡萝卜素通过综合电子、膜和代谢组学分析诱导胃癌细胞中的条件依赖性氧化还原重塑：基于类胡萝卜素筛选比较后的研究
Sergio Gonzalez,Lina M Trujillo-Chacón,Isabel Cristina Henao-Castañeda et al.
Sergio Gonzalez et al.
Carotenoids are traditionally described as antioxidants; however, their biological activity depends on cellular and environmental context. In tumor cells with dysregulated redox homeostasis, it remains unclear whether β-carotene stabilizes...
Ubiquitin-specific protease 48: Molecular mechanisms, pathophysiological roles and therapeutic potential [0.03%]
泛素特异性蛋白酶48：分子机制、病理生理作用和治疗潜力
Hu Lei,Chujiao Zhu,Li Yang et al.
Hu Lei et al.
Ubiquitin-specific protease 48 (USP48) is a deubiquitinase (DUB) belonging to the USP subfamily, the largest and functionally most diverse class of DUBs. As a critical post-translational regulator, USP48 governs a wide range of physiologica...
Corrigendum to "Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis" [Biochem. Biophys. Res. Commun. 800 (2026) 153270] [0.03%]
“菝葜根茎天然类外泌体纳米囊泡通过GPX4/ACSL4轴诱导肝癌细胞线粒体自噬依赖性铁死亡”一文的勘误[Biochem. Biophys. Res. Commun. 800 (2026) 153270]
Xiayi Fang,Zicheng Liang,Zhen Zhang et al.
Xiayi Fang et al.
Hydrogels in Pharmaceutical Formulation: Properties, formulation strategies, and drug delivery applications [0.03%]
医药配方中的水凝胶：特性、配方策略和药物输送应用
Suriya Prakaash Kannan,Dakshinesh Parameswaran,Damodharan Narayanasamy
Suriya Prakaash Kannan
Objectives: This review aims to provide a systematic overview of hydrogel systems as pharmaceutical excipients for drug delivery. It focuses on their classification, formulation strategies, physicochemical properties, and...
Key genes identified in ammonia-induced cell death during pediatric sepsis: Machine learning, single-cell, and virtual gene knockout approaches [0.03%]
儿童脓毒症中氨诱导细胞死亡的关键基因：机器学习、单细胞和虚拟基因敲除方法识别发现
Yong Feng Huang,Xing Chuan Li,Ran Jiang
Yong Feng Huang
Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. Ammonia-induced cell death (AICD) is a novel form of cell death, and its association with sepsis remains un...
Convergent genetic and structural parameters of cardiovascular disease related insights of post-acute COVID-19 [0.03%]
急性COVID-19后心血管疾病的相关遗传和结构参数的汇聚带来的新见解
Rajas M Rao,Narendra Kumar,Shaminth Prasad P et al.
Rajas M Rao et al.
Post-Acute Sequelae of COVID-19 (PASC) is increasingly associated with long-term cardiovascular complications, yet the underlying molecular mechanisms, remain poorly understood. Host genetic susceptibility is likely to modulate post-viral c...
High temperature induces lipid peroxidation and PPARα-dependent peroxisomal remodeling in fish cells [0.03%]
高温诱导鱼类细胞脂质过氧化及PPARα依赖的过氧化物酶体重塑
Saya Okada,Konosuke Sakima,Wataru Kawamura et al.
Saya Okada et al.
High-temperature (HT) stress induces female-to-male sex reversal (masculinization) in the teleost fish medaka (Oryzias latipes). Previous studies have shown that activation of peroxisome proliferator-activated receptor α (PPARα) signaling...
Blebbistatin paradoxically induces ROCK-dependent junctional enrichment of p-MLC and adherens junction components in chick embryo epidermis [0.03%]
鬼臼并茋通过ROCK依赖方式在鸡胚表皮诱导pMLC和粘附斑成分聚集的悖论现象研究
Pengfei Shen,Renyikun Yuan,Fanke Huang et al.
Pengfei Shen et al.
The phosphorylation level of myosin light chain (p-MLC) is widely employed as a biochemical surrogate for cellular contractility in tissue mechanics studies, while small-molecule inhibitors such as Blebbistatin are routinely used to suppres...