Stepwise changes in gene expression inducing anhydrobiotic state transition and the gene regulatory network in Polypedilum vanderplanki larvae [0.03%]
范德普兰克拟蚊幼虫滞育转变过程中基因表达的动态变化及其基因调控网络
Yusuke Hiki,Takahiro G Yamada,Richard Cornette et al.
Yusuke Hiki et al.
The larva of the sleeping chironomid, Polypedilum vanderplanki, is the only insect capable of extreme desiccation tolerance, known as anhydrobiosis. The larvae can survive near-complete desiccation and, upon rehydration, rapidly resume meta...
Single-cell RNA sequencing data analysis reveals differential expressions of ion channels in immunity response to pulmonary COVID-19 infection [0.03%]
单细胞RNA测序数据分析揭示了离子通道在肺部COVID-19感染免疫反应中的差异表达
Xin Wu,Vishwa Bhatt,Jianhua J Liu et al.
Xin Wu et al.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by immune dysregulation that contributes to disease severity and systemic inflammation. Ion channels are critical ...
Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis [0.03%]
中国薯蓣块茎的天然类外泌体纳米囊泡通过GPX4 / ACSL4轴诱导线粒体自噬依赖性铁死亡以治疗肝癌
Xiayi Fang,Zicheng Liang,Zhen Zhang et al.
Xiayi Fang et al.
Background: Hepatocellular carcinoma (HCC) remains challenging due to limited therapies and resistance. Mitophagy-associated ferroptosis, an iron-dependent cell death mechanism, emerges as a novel strategy, while plant-de...
Antioxidant and antibacterial effects of human plasma-based scavenging protein cocktail on burn wound healing in vitro [0.03%]
人血浆衍生的抗氧化蛋白混合物的体外促烧伤创面愈合作用及抗氧化、抗菌作用研究
Jackson Duan,Rose Gibbons,Ivan S Pires et al.
Jackson Duan et al.
In the United States, 400,000 or more fire or burn-related injuries are reported annually. Post-burn, there is a release of reactive oxygen species (ROS) as a result of hemolysis. Excess ROS causes oxidative stress that harms the surroundin...
Identification of RALY as a novel regulator of DSCR1 transcription [0.03%]
识别新型转录调控因子RALY调节DSCR1基因表达
Jiwon Park,Chiyeol Choi,Hyerin Kim et al.
Jiwon Park et al.
Down syndrome critical region 1 (DSCR1) is located on chromosome 21, whose N-terminal coding sequence lacks recognizable motifs, and its precise transcriptional and translational regulation remains incompletely understood. Utilizing a bicis...
Knockdown of histone H2A deubiquitinase BAP1 in human embryonic stem cells restricts their differentiation repertoire but is dispensable for maintaining their undifferentiated state [0.03%]
人胚胎干细胞中组蛋白H2A去泛素化酶BAP1敲低限制其分化谱系但不能维持其未分化状态
Dharitree Samal,Prasad Pethe
Dharitree Samal
Polycomb group proteins (PcGs) such as RING1B catalyze the addition of repressive histone mark (H2AK119ub1), while histone H2A deubiquitinases such as BAP1 remove this repressive mark. Interplay between these two proteins allows for fine co...
STAM1-deficient mice exhibit an attention-deficit/hyperactivity disorder-like phenotype [0.03%]
STAM1缺陷小鼠表现出类似注意力缺陷多动障碍的表型
Hironori Fujiwara,Osamu Nakagawasai,Shuhei Suzuki et al.
Hironori Fujiwara et al.
Despite recent abundant studies on animal models of attention-deficit/hyperactivity disorder (ADHD), a complete model remains unestablished. In this study, we investigated the potential of STAM1-deficient mice as a new animal model for ADHD...
Caspr1 silencing promotes axon regeneration in both peripheral and central nervous systems via negative regulation of neurofascin [0.03%]
沉默Caspr1通过负调控神经纤连蛋白促进外周和中枢神经系统轴突再生
Yan-Xia Ma,Shan-Wen Wei,Hao-Nan Zhang et al.
Yan-Xia Ma et al.
The regenerative capacity of the adult mammalian central nervous system is severely limited, posing a significant challenge for functional recovery after injury. To explore novel approaches to support neuronal regeneration, this study exami...
Targeting SLC7A11 sensitizes colorectal cancer cells to elesclomol-Cu-induced cuproptosis via the GSH-GPX4 axis [0.03%]
靶向SLC7A11通过GSH-GPX4轴增强Elesclomol-Cu诱导的结直肠癌细胞铜依赖性细胞死亡(Cuproptosis)敏感性
Jun Jiang,Fangzhou Ye,Jiayi Wang et al.
Jun Jiang et al.
Background: A recently identified type of copper-induced cell death that may contribute to tumor development is cuprotosis. However, uncertainty surrounds its molecular regulation mechanism in colorectal cancer (CRC). Cla...
Peptidomics-derived peptides enhance antiviral defense against ChiVMV in Nicotiana tabacum [0.03%]
基于肽组学的多肽可增强烟草原生质体对ChiVMV的抗病毒防御响应
Jianmin Zeng,Changjun Huang,Yong Liu et al.
Jianmin Zeng et al.
Chilli veinal mottle virus (ChiVMV) is an important potyvirus for which deployable host resistance remains limited in breeding. Here, we used an omics-to-function workflow to identify infection-responsive peptides with antiviral activity. P...