Inhibited proliferation and immune evasion of lung cancer: The key role of miR-4483 in lncRNA linc00824/miR-4483/PD-L1 pathway [0.03%]
肺癌增殖受抑和免疫逃逸：lncRNA linc00824/miR-4483/PD-L1通路中miR-4483的关键作用
Jia-Xiang Zhang,Jun-Ming Qiu,Nana Wang et al.
Jia-Xiang Zhang et al.
Growing evidence indicates that lactate and long non-coding RNAs (lincRNAs) exert a crucial influence on tumor development. This study aimed to investigate lactate-induced histone lactylation promotes the roles of lincRNA in lung cancer pro...
M2 macrophage-derived exosomes improve periodontitis-induced inflammatory bone loss by regulating glycolysis in male rats [0.03%]
雄性大鼠牙周炎模型中M2型巨噬细胞源外泌体通过调节糖酵解改善炎性骨丢失
Fan Bao,Ye Zhang,Jie Pan et al.
Fan Bao et al.
M2 macrophage-derived exosomes (M2-Exo) have emerged as promising therapeutic agents for bone regeneration; however, the mechanisms underlying their protective effects against periodontitis-associated bone loss remain poorly understood. In ...
Retraction notice to "LncRNA Linc-PINT inhibits miR-523-3p to hamper retinoblastoma progression by upregulating Dickkopf-1 (DKK1)" [Biochem. Biophys. Res. Commun. 530 (2020) 47-53] [0.03%]
撤稿：长链非编码RNA Linc-PINT通过上调Dickkopf-1（DKK1）抑制miR-523-3p来抑制视网膜母细胞瘤的进展[Biochem. Biophys. Res. Commun. 530 (2020) 47-53]
Xiaoping Zhou,Yongping Wang,Qiang Li et al.
Xiaoping Zhou et al.
Integrated biophysical, thermodynamic and cellular evaluation of prunetin as an α-glucosidase inhibitor: Insights from ITC, fluorescence quenching and molecular dynamics [0.03%]
普卢尼汀作为α-葡萄糖苷酶抑制剂的综合生物物理、热力学和细胞评价：来自ITC、荧光淬灭和分子动力学的见解
Deepanshi Vijh,Faiza Iram,Sourbh Suren Garg et al.
Deepanshi Vijh et al.
Inhibition of carbohydrate-hydrolysing enzymes, such as α-glucosidase, is an established method for controlling postprandial hyperglycemia in Type 2 diabetes (T2D). In the current work, a detailed mechanistic investigation of the interrela...
Astaxanthin attenuates skeletal muscle atrophy and mitochondrial dysfunction in streptozotocin-induced diabetic rats [0.03%]
虾青素通过改善链脲佐菌素诱导的糖尿病大鼠骨骼肌线粒体功能障碍来预防肌肉萎缩的作用研究
Masayuki Tanaka,Miho Kanazashi,Ryosuke Nakanishi et al.
Masayuki Tanaka et al.
Diabetes mellitus (DM) induces skeletal muscle atrophy and mitochondrial dysfunction. Although antioxidant supplementation has exhibited beneficial effects on diabetic skeletal muscle, the effects of astaxanthin (AST), a potent antioxidant ...
FGF13 exerts neuroprotective effects via activation of the PI3K/AKT signaling pathway and serves as a potential biomarker for depression [0.03%]
FGF13通过激活PI3K/AKT信号通路发挥神经保护作用并可作为抑郁症潜在的生物标志物
Haitao Hu,Juan Lu,Xin Du et al.
Haitao Hu et al.
Depression is a highly recurrent psychiatric disorder characterized by persistent low mood, anhedonia, and sleep disturbances. The clinical diagnosis of depression currently relies primarily on clinical interviews and standardized assessmen...
Structure and functional analysis of two insulin superfamily members in the Pacific white shrimp Litopenaeus vannamei [0.03%]
太平洋白虾凡纳滨对虾胰岛素超家族两个成员的结构与功能分析
Peiling Liu,Xiaojun Zhang,Jianbo Yuan et al.
Peiling Liu et al.
The insulin superfamily constitutes a phylogenetically conserved hormonal system that critically regulates growth, metabolism, and reproduction in Metazoa. However, the functional diversification and the architecture of its regulatory netwo...
Zheng Li,Xue-Long Yang,Yue Yu et al.
Zheng Li et al.
A series of novel HuR inhibitors were designed and synthesized. Evaluation of HuR binding affinity and antitumor activity against MDA-MB-231 cells demonstrated that most compounds exhibited potent HuR engagement and pronounced antitumor eff...
ClpC2 plays an essential role in shoot and root growth in Arabidopsis thaliana [0.03%]
CLPC2在拟南芥地上和地下部生长中起着重要作用
Xiaomei Chen,Ting Guo,Danni Lin et al.
Xiaomei Chen et al.
Chaperones are essential for Clp protease that governs protein quality control in chloroplast. However, it remains poorly understood whether and how individual ClpC proteins play distinct roles in plant growth and development. In this study...
SERBP1 promoter single nucleotide polymorphism (SNP) rs3762314: a genetic susceptibility biomarker promoting malignant phenotype in hepatocellular carcinoma [0.03%]
肝细胞癌恶性表型的遗传易感生物标志物SERBP1启动子单核苷酸多态性（SNP）rs3762314
Meixia Wang,Han Liu,Cancan Guo et al.
Meixia Wang et al.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. SERPINE1 mRNA binding protein 1 (SERBP1) has been implicated as an oncogenic factor in HCC; however, the role of SERBP1 single nucleotide pol...