Integrated biophysical, thermodynamic and cellular evaluation of prunetin as an α-glucosidase inhibitor: Insights from ITC, fluorescence quenching and molecular dynamics
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Inhibition of carbohydrate-hydrolysing enzymes, such as α-glucosidase, is an established method for controlling postprandial hyperglycemia in Type 2 diabetes (T2D). In the current work, a detailed mechanistic investigation of the interrelationship between α-... ...
